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dc.contributor.authorvan den Ham WA
dc.contributor.authorJansen EHJM
dc.contributor.authorde Fluiter P
dc.contributor.authorvan Leeuwen FXR
dc.date.accessioned2017-02-20T07:53:51
dc.date.issued1992-12-31
dc.identifier618902009
dc.description.abstractIn a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg di(isodecyl)phthalate (DIDP)kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates which are related with peroxisome proliferation. No effects have been observed on liver and body weight. CAT appeared to be the most sensitive parameter with a dose-without-effect (DWE) of 60 mg DIDP/kg diet, corresponding with 5.6 mg DIDP/kg b.w./day. The other enzyme parameters PCO, ECH and LAH showed no effect at 200 mg DIDP/kg diet, corresponding with 18.4 mg/kg b.w/day. Since CAT is considered to be not specific for peroxisome proliferation this latter value has been established as overall no-observed-effect-level.<br>
dc.description.sponsorshipHIGB
dc.format.extent31 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618902009
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902009.html
dc.subject07nl
dc.subjectftalatennl
dc.subjecttoxiciteitstestennl
dc.subjectdiermodelnl
dc.subjectenzymennl
dc.subjectphthalatesen
dc.subjecttoxicity testingen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.subjectdidpen
dc.titleToxicological investigation of di(isodecyl)phthalate in ratsen
dc.title.alternative[Toxicologisch onderzoek naar di(isodecyl)ftalaat in ratten.]nl
dc.typeReport
dc.date.updated2017-02-20T06:53:52Z
html.description.abstractIn a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg di(isodecyl)phthalate (DIDP)kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates which are related with peroxisome proliferation. No effects have been observed on liver and body weight. CAT appeared to be the most sensitive parameter with a dose-without-effect (DWE) of 60 mg DIDP/kg diet, corresponding with 5.6 mg DIDP/kg b.w./day. The other enzyme parameters PCO, ECH and LAH showed no effect at 200 mg DIDP/kg diet, corresponding with 18.4 mg/kg b.w/day. Since CAT is considered to be not specific for peroxisome proliferation this latter value has been established as overall no-observed-effect-level.&lt;br&gt;


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