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dc.contributor.authorde Klerk A
dc.contributor.authorVerlaan APJ
dc.contributor.authorBeekhof P
dc.contributor.authorvan Soolingen D
dc.contributor.authorvan Loveren H
dc.date.accessioned2017-02-20T07:27:37
dc.date.issued1989-12-31
dc.identifier618508001
dc.description.abstractIn this report of inhalatory exposure to fly ash aerosol on the immune system of the rat are described. Effects on both specific immunity and on non-specific defense mechanisms were noted. With regard to non-specific defense machanisms NK activity appeared stimulated in rats exposed during 4 weeks (5 dyas per week, 6 hrs per day) to 10 and 30 mg fly ash/m3 whereas at a concentration of 100 mg/m3 a decreased activity was noted. Macrophage activity in exposed rats was signigicantly increased. With regard to specific immune system, in lung draining lymph nodes a signigicant increased number of both T and B lymphocytes was observed. In serum of exposed rats a significant increase of upto 150% of the IgA content was found. From these data it can be concluded that inhaltory exposure to fly ash aerosol influences the specific and non-specific defense mechanisms<br>
dc.description.sponsorshipNederlandse Maatschappij voor Energie en Milieu BV (NOVEM)
dc.format.extent26 p
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618508001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618508001.html
dc.subject07nl
dc.subjectimmunotoxicologienl
dc.subjectfagocytosenl
dc.subjectnatural killer activiteitnl
dc.subjectt/b cel rationl
dc.subjectantilichaam spiegelsnl
dc.titleEffecten van inhalatoire blootstelling gedurende vier weken aan vliegas op het immuunsysteem van de ratnl
dc.title.alternativeEffects of inhalatory 4 weeks exposure to respirable fly ash on the immune system of the raten
dc.typeReport
dc.date.updated2017-02-20T06:27:38Z
html.description.abstractIn this report of inhalatory exposure to fly ash aerosol on the immune system of the rat are described. Effects on both specific immunity and on non-specific defense mechanisms were noted. With regard to non-specific defense machanisms NK activity appeared stimulated in rats exposed during 4 weeks (5 dyas per week, 6 hrs per day) to 10 and 30 mg fly ash/m3 whereas at a concentration of 100 mg/m3 a decreased activity was noted. Macrophage activity in exposed rats was signigicantly increased. With regard to specific immune system, in lung draining lymph nodes a signigicant increased number of both T and B lymphocytes was observed. In serum of exposed rats a significant increase of upto 150% of the IgA content was found. From these data it can be concluded that inhaltory exposure to fly ash aerosol influences the specific and non-specific defense mechanisms&lt;br&gt;


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