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dc.contributor.authorMohn GR
dc.contributor.authorStel JJ van der
dc.contributor.authorStavenuiter JFC
dc.contributor.authorHamzink MRJ
dc.contributor.authorKreijl CF
dc.date.accessioned2012-12-12T16:19:24Z
dc.date.available2012-12-12T16:19:24Z
dc.date.issued1996-04-30
dc.identifier659001004
dc.identifier.urihttp://hdl.handle.net/10029/257909
dc.description.abstractDe mutagene en antimutagene eigenschappen van bioflavonoiden werden in de bacteriele mutageniteitstest van Ames met Salmonella typhimurium stammen TA98 en TA100 onderzocht. De volgorde van mutagene activiteit voor beide stammen in aanwezigheid van metabole activering was quercetine>myricetine-kaempferol>morin hydraat. De stoffen galangin, luteoline, apigenine en chrysin vertoonden geen mutagene werking voor Salmonella TA98 en/of TA100. De antimutagene werking van de bioflavonoiden werd bepaald tegen de mutagene werking van benzo(a)pyreen in Salmonella stammen TA98 en TA100. Alle hier onderzochte stoffen, inclusief de stof met het laagst aantal hydroxylgroepen en chrysin vertoonden een antimutagene werking tegen de mutageniteit van benzo(a)pyreen.
dc.description.abstractThe mutagenic and antimutagenic properties of bioflavonoids were determined in the bacterial mutagenicity test of Ames, using Salmonella typhimurium strains TA98 and TA100. The decreasing order of mutagenic activity found in both strains was quercetin>myricetin-kaempferol>morin hydrate. The compounds galangin, luteolin, apigenin, and chrysin were devoid of mutagenic activity under the present conditions. The antimutagenic activity of the bioflavonoids was measured against the mutagenic activity of benzo(a)pyrene (BaP) in Salmonella strains TA98 and TA100. All compounds investigated, including the compound with the lowest number of hydrozyl side groups and chrysin, did show antimutagenic activity against BaP-induced mutagenesis.
dc.description.sponsorshipRIVM
dc.formatapplication/pdf
dc.format.extent32 p
dc.format.extent1397 kb
dc.language.isoen
dc.relation.ispartofRIVM Rapport 659001004
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/659001004.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/659001004.pdf
dc.subject03nl
dc.subjectbioflavonoidsen
dc.subjectmutagenicity testingen
dc.subjectantimutagenic agentsen
dc.subjectbenzo(a)pyreenen
dc.titleMutagenic and antimutagenic activities of bioflavonoids and structural analogues in the Ames/Salmonella testen
dc.title.alternativeMutagene en antimutagene activiteit van bioflavonoiden en analoge verbindingen in de Ames/Salmonella testnl
dc.typeReport
dc.contributor.departmentLEO
dc.contributor.departmentLBO
dc.date.updated2012-12-12T16:19:25Z
html.description.abstractDe mutagene en antimutagene eigenschappen van bioflavonoiden werden in de bacteriele mutageniteitstest van Ames met Salmonella typhimurium stammen TA98 en TA100 onderzocht. De volgorde van mutagene activiteit voor beide stammen in aanwezigheid van metabole activering was quercetine>myricetine-kaempferol>morin hydraat. De stoffen galangin, luteoline, apigenine en chrysin vertoonden geen mutagene werking voor Salmonella TA98 en/of TA100. De antimutagene werking van de bioflavonoiden werd bepaald tegen de mutagene werking van benzo(a)pyreen in Salmonella stammen TA98 en TA100. Alle hier onderzochte stoffen, inclusief de stof met het laagst aantal hydroxylgroepen en chrysin vertoonden een antimutagene werking tegen de mutageniteit van benzo(a)pyreen.
html.description.abstractThe mutagenic and antimutagenic properties of bioflavonoids were determined in the bacterial mutagenicity test of Ames, using Salmonella typhimurium strains TA98 and TA100. The decreasing order of mutagenic activity found in both strains was quercetin>myricetin-kaempferol>morin hydrate. The compounds galangin, luteolin, apigenin, and chrysin were devoid of mutagenic activity under the present conditions. The antimutagenic activity of the bioflavonoids was measured against the mutagenic activity of benzo(a)pyrene (BaP) in Salmonella strains TA98 and TA100. All compounds investigated, including the compound with the lowest number of hydrozyl side groups and chrysin, did show antimutagenic activity against BaP-induced mutagenesis.


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