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    Een epidemische verheffing van gonokokken met resistentie tegen penicilline en tetracyline

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    Authors
    van de Laar MJW
    van Duynhoven YTHP
    van Klingeren B
    Dessens-Kroon M
    Verheuvel M
    Type
    Report
    Language
    nl
    
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    Title
    Een epidemische verheffing van gonokokken met resistentie tegen penicilline en tetracyline
    Translated Title
    [An epidemic of gonococci with resistance to both penicillin and tetracyclin.]
    Publiekssamenvatting
    This report describes a study which was carried out to investigate an epidemic of gonococci with resistance to penicillin and tetracyclin (TRNG/PPNG). This study involved all PPNG-isolates which were sent in by five laboratories from Amsterdam, Rotterdam and The Hague in 1989-1990. The epidemic of TRNG/PPNG was found to be related mainly to three strains: NR/IB-6, PRO/IA-3, PRO/IA-6 with the plasmid pattern 3.2+25.2. The introduction of TRNG/PPNG presumably took place in The Hague in 1988. Independent risk factors of an infection due to TRNG/PPNG were for men: age above 40 years, and sexual contact with a prostitute (only for men in Rotterdam and The Hague). No relation with prostitution was found for men in Amsterdam. Independent risk factors were for women: age above 40 years and Turkish or Latin American nationality. Strains from The Hague were also independently correlated to TRNG/PPNG. Further spread of resistant strains seems to be related to prostitution, but only in Rotterdam and The Hague. The outbreak of TRNG/PPNG underlined the necessity for a continuous surveillance of resistance of gonococci including some background variables of patients.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    GHI
    RIVM
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