• Login
    View Item 
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WARPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartment

    My Account

    LoginRegister

    Statistics

    Display statistics

    Lifestyle and cancer of the reproductive organs

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Piersma AH
    Spanjersberg MQI
    Beekhuijzen MEW
    Type
    Onderzoeksrapport
    Language
    en
    
    Metadata
    Show full item record
    Title
    Lifestyle and cancer of the reproductive organs
    Translated Title
    Leefstijl en kanker van de geslachtsorganen
    Publiekssamenvatting
    De incidenties van borstkanker, testiskanker en prostaatkanker nemen in de westerse wereld toe. Er is sprake van zorg dat blootstelling van de mens aan stoffen in het leefmilieu met endocriene activiteit betrokken zouden kunnen zijn bij deze trends, maar ondersteunend bewijs voor een dergelijke relatie ontbreekt tot dusverere. Anderzijds heeft de twintigste eeuw diepgaande veranderingen in leefstijl te zien gegeven, die ongetwijfeld invloed hebben gehad op de incidenties van ziekten en aandoeningen. Het rapport vat huidige kennis samen omtrent de relatie tussen hormoon-afhankelijke kankers bij de mens en leefstijldeterminanten. Belangrijke leefstijldeterminanten betrokken bij deze kankers worden gevonden op de gebieden van consumptief en sexueel gedrag. Specifieke determinanten daarbinnen zijn calorische inname, lichamelijke activiteit, alcoholconsumptie, kindertal, hormoonmedicatie, sexuele activiteit en hygiene.
    The incidence of breast cancer, testicular cancer and prostate cancer is increasing in Western societies. Concern has been expressed that human exposure to environmental xenobiotic compounds coupled with endocrine activity may play a role in these cancers, but supporting evidence for the existence of such a relationship is lacking. On the other hand, the twentieth century has seen profound changes in lifestyle, which have undoubtedly influenced the incidence of diseases. This report summarises present knowledge on the relationship between hormone-dependent cancers in humans and lifestyle determinants. Major lifestyle determinants related to reproductive cancer appear to be found in eating and reproductive behaviour. Specific determinants within these areas include caloric intake, physical activity, alcohol consumption, parity, exogenous hormone treatments, sexual activity and hygiene. Dramatic changes in eating patterns in the twentieth century with increased caloric intake in the presence of decreased physical activity, and increased alcohol intake and increased female smoking are thought to have promoted reproductive cancers. In addition, profound changes in reproductive behaviour with decreased parity, increased maternal age, increased sexual activity, wide application of various types of sex hormone therapy and contraceptive measures are thought to have contributed to increased reproductive cancer incidences. Current knowledge on determinants of reproductive cancer suggests that lifestyle determinants may play a more prominent role in determining trends in reproductive cancer incidences than exposure to environmental xenobiotic compounds acting on the endocrine. However, data on human exposure to environmental endocrine-active compounds are needed to allow an analysis of the actual risk of exposure to these compounds in relation to reproductive organ cancer.
    Sponsors
    VWS
    URI
    http://hdl.handle.net/10029/258089
    Collections
    RIVM official reports

    entitlement

     

    Related items

    Showing items related by title, author, creator and subject.

    • Thumbnail

      Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

      Stepien, Magdalena; Jenab, Mazda; Freisling, Heinz; Becker, Niels-Peter; Czuban, Magdalena; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; et al. (2017-07-01)
      Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
    • Thumbnail

      Measured Adiposity in Relation to Head and Neck Cancer Risk in the European Prospective Investigation into Cancer and Nutrition.

      Ward, Heather A; Wark, Petra A; Muller, David C; Steffen, Annika; Johansson, Mattias; Norat, Teresa; Gunter, Marc J; Overvad, Kim; Dahm, Christina C; Halkjær, Jytte; et al. (2017-06)
      Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23-2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction = 0.004). Among men, WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21-1.65).Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated.Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence. Cancer Epidemiol Biomarkers Prev; 26(6); 895-904. ©2017 AACR.
    • Thumbnail

      Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.

      Aleksandrova, Krasimira; Schlesinger, Sabrina; Fedirko, Veronika; Jenab, Mazda; Bueno-de-Mesquita, Bas; Freisling, Heinz; Romieu, Isabelle; Pischon, Tobias; Kaaks, Rudolf; Gunter, Marc J; et al. (2017-05-01)
      Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. <300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = 1.07, 95% confidence interval: 0.68, 1.66). This association was accounted for mostly by attained waist circumference (reduction of 61%) and by the biomarkers soluble leptin receptor (reduction of 43%) and glycated hemoglobin (reduction of 28%). These novel data suggest that the observed association between adult weight gain and colon cancer could be primarily explained by attained abdominal fatness and biomarkers of metabolic dysfunction.

    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.