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dc.contributor.authorOlling M
dc.contributor.authorDerks HJGM
dc.contributor.authorBerende PLM
dc.contributor.authorVugt F van
dc.contributor.authorLiem AKD
dc.contributor.authorJong APJM de
dc.date.accessioned2012-12-12T17:03:19Z
dc.date.available2012-12-12T17:03:19Z
dc.date.issued1990-05-31
dc.identifier328904001
dc.identifier.urihttp://hdl.handle.net/10029/258422
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractIn this report a toxicokinetic experiment with eight 13C-labelled polychlorinated dibenzo-p-dioxins and -furans in lactating cows is described. The test compounds were intraruminally administered as a single dose and the concentrations of the congeners in milk- and subcutaneous concentrations in other fat tissues were determined after slaughtering of the animals. Absorption from the gastrointestinal tract appeared to be rapid but the distribution phase took at least six days. The mean elimination halflife in milk fat of the congeners contributing predominantly to TEQ-values was between 40 and 50 days. The bioavailability from the dosage form used was approximately 30%. The ratio between the concentration of the TEQ-dominating congeners in body fat and milkfat varied between 1 and 2. Although the concentrations in the various fat compartments seemed to be in equilibrium to a considerable extent, as yet unexplained deviations have been found in some instances.
dc.description.sponsorshipVHI Dienst Landbouwkundig Onderzoek (DLO)
dc.format.extent36 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 328904001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/328904001.html
dc.subject07nl
dc.subjectpcddnl
dc.subjectpcdfnl
dc.subjecttcddnl
dc.subjectmelknl
dc.subjectdioxinenl
dc.titleDe toxicokinetiek van polychloor-dibenzo-p-dioxinen en-furanen in de lacterende koe (I)nl
dc.title.alternativeToxicokinetics of polychlorinated dibenzo-p-dioxins and -furans in lactating cowsen
dc.typeReport
dc.date.updated2012-12-12T17:03:20Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractIn this report a toxicokinetic experiment with eight 13C-labelled polychlorinated dibenzo-p-dioxins and -furans in lactating cows is described. The test compounds were intraruminally administered as a single dose and the concentrations of the congeners in milk- and subcutaneous concentrations in other fat tissues were determined after slaughtering of the animals. Absorption from the gastrointestinal tract appeared to be rapid but the distribution phase took at least six days. The mean elimination halflife in milk fat of the congeners contributing predominantly to TEQ-values was between 40 and 50 days. The bioavailability from the dosage form used was approximately 30%. The ratio between the concentration of the TEQ-dominating congeners in body fat and milkfat varied between 1 and 2. Although the concentrations in the various fat compartments seemed to be in equilibrium to a considerable extent, as yet unexplained deviations have been found in some instances.


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