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    Viruses and cancer

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    Authors
    Krul MRL
    van Kranen HJ
    van Kreijl CF
    Steerenberg PA
    van Loon AM
    Type
    Report
    Language
    en
    
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    Title
    Viruses and cancer
    Translated Title
    Virussen en kanker
    Publiekssamenvatting
    The aim of this report is to review the relationship between viruses and the development of human cancer. It is currently known at least four viruses are directly implicated in the aetiology of human cancers and are involved in the induction of 15 to 20% of the worldwide tumor burden. Infection with these viruses seems to be an essential, but not sufficient, step in the multistage proces of carcinogenesis. Other changes, induced for instance by chemical carcinogens or radiation, are also required to change the virus infected cell into a tumor cell. The four most important human tumor viruses are: human T cell leukemia viruses (HTLV); Epstein-Barr virus (EBV); hepatitis B virus (HBV) and human papillomavirus (HPV). Because of HPV is probably involved in the development of over 10% of all human tumors and hence is the most important biological agent in relation to cancer, it is discussed more extensively in this report.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
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    RIVM
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