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dc.contributor.authorGoettsch W
dc.contributor.authorGarssen J
dc.contributor.authorde Gruijl FR
dc.contributor.authorvan Loveren H
dc.date.accessioned2012-12-12T17:40:03Z
dc.date.available2012-12-12T17:40:03Z
dc.date.issued1992-05-31
dc.identifier850017001
dc.identifier.urihttp://hdl.handle.net/10029/258817
dc.description.abstractAs a results of a depletion of atmospheric ozone all living organisms on the earth"s surface may be exposed to increased amounts of ultraviolet radiation. In man, ultraviolet radiation (UVR, especially UV-B) can cause, in addition to some beneficial effects like vitaming D formation, deleterious effects on the human health. Examples are diseasesof the skin, like erythema, photoageing and skin cancer and diseases of the eye, like keratitis and cataract. There are reasons to believe that UV-B radiation depresses the immunity against tumours and infectious diseases. It was demonstrated that UV-B suppresses the resistance against UV-induced tumours in mice and that this suppression is transferable to other mice if lymphocytes of UV-irradiated animals are used. Clinical research showed the induction of suppressor cells and inhibition of the NK activity by exposure to sunlight. UV-B can interact in diffrent ways with the immune system; antigen-presenting cells in the skin can be affected, the homing of lymphocytes may be distrurbed and the amount of suppressor cells often increased. More research is needed to establish relations between depressed immunity and decreased resistance against infections and tumours, so that these can serve as the basis for risk assessment of UV-B<br>
dc.description.sponsorshipRIVM
dc.description.sponsorshipNationale Onderzoekprogramma (NOP) Mondiale Biosfeer
dc.format.extent45 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 850017001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/850017001.html
dc.subject03nl
dc.subjectuv-stralingnl
dc.subjectblootstellingnl
dc.subjecteffectennl
dc.subjectgezondheidnl
dc.subjectimmuunsysteemnl
dc.subjectrisico analysenl
dc.subjectuv radiationen
dc.subjectexposureen
dc.subjecthealth effectsen
dc.subjectimmune systemen
dc.subjectrisk analysisen
dc.titleHealth effects of UV-B exposure; with special emphasis on the immune systemen
dc.title.alternativeGezondheidseffecten van UV-B blootstelling: met speciale aandacht voor het immuunsysteemnl
dc.typeReport
dc.date.updated2012-12-12T17:40:04Z
html.description.abstractAs a results of a depletion of atmospheric ozone all living organisms on the earth&quot;s surface may be exposed to increased amounts of ultraviolet radiation. In man, ultraviolet radiation (UVR, especially UV-B) can cause, in addition to some beneficial effects like vitaming D formation, deleterious effects on the human health. Examples are diseasesof the skin, like erythema, photoageing and skin cancer and diseases of the eye, like keratitis and cataract. There are reasons to believe that UV-B radiation depresses the immunity against tumours and infectious diseases. It was demonstrated that UV-B suppresses the resistance against UV-induced tumours in mice and that this suppression is transferable to other mice if lymphocytes of UV-irradiated animals are used. Clinical research showed the induction of suppressor cells and inhibition of the NK activity by exposure to sunlight. UV-B can interact in diffrent ways with the immune system; antigen-presenting cells in the skin can be affected, the homing of lymphocytes may be distrurbed and the amount of suppressor cells often increased. More research is needed to establish relations between depressed immunity and decreased resistance against infections and tumours, so that these can serve as the basis for risk assessment of UV-B&lt;br&gt;


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