• Login
    View Item 
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    RIVM Publications RepositoryCommunitiesTitleAuthorsIssue DateSubmit Date

    My Account

    LoginRegister

    Statistics

    Display statistics

    Dose response relations for gastro-instestinal pathogens in an animal model

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Havelaar AH
    Garssen J
    Takumi K
    Koedam M
    Dufrenne JB
    van Leusden FM
    de la Fonteyne L
    Vos JG
    Type
    Report
    Language
    en
    
    Metadata
    Show full item record
    Title
    Dose response relations for gastro-instestinal pathogens in an animal model
    Translated Title
    Dosis response relatie voor gastro-intestinale pathogenen in een diermodel
    Publiekssamenvatting
    Dosis-respons modellen zijn een belangrijk onderdeel van de kwantitatieve microbiologische risicoanalyse, maar er zijn slechts weinig bruikbare kwantitatieve gegevens. Experimenten met vrijwilligers geven slechts beperkte informatie. Daarom wordt een diermodel voor infectie met enteropathogene bacterien ontwikkeld. Volwassen, mannelijke WU ratten werden na overnacht vasten en neurtralisatie van maagzuur blootgesteld aan verschillende doses van drie enteropathogene bacterien (Salmonella enterica serovar Enteritidis, Escherichia coli 0157 en Campylobacter jejuni). Er werd een relatie gevonden tussen de dosis en de kans op infectie voor alle onderzochte bacterien. C. jejuni was meer infectieus dan E.coli 0157 en S. Enteritidis was het minst infectieus. S.Enteritidis veroorzaakte ook systemische effecten. Een dodis-respons relatie werd gevonden met sommige hematologische parameters (met name een toename van neurofielen), met de vertraagd type overgevoeligheidsreactie (OTV) en met histopathologische veranderingen in het darmkanaal. De reproduceerbaarheid van de experimenten met S.Enteritidis was goed, in tegenstelling tot C.jejuni<br>
    Dose-response models ar an essential part of quantitative microbiological risk assessment, but not many appropriate data are available for this purpose. Human volunteer studies provide only limited information. Therefore, an animal model for infection with human enteropathogenic bacteria is being developed. Adult, male WU rats were exposed to different doses of three enteropathogenic bacteria (Salmonella enterica serovar Enteritidis, Escherichia coli 0157, and Campylobacter jejuni) after overnight starvation and neutralisation of gastric acid. A relationship between the dose and probability of infection was demonstrated for all three bacteria, with C. jejuni being more infectious than E.coli 0157, and CS. Enteritidis being least infectious. S. Enteritidis induced a systemic infection, and dose-dependent effects were observed for some haematological parameters (notably and increase in neutrophils), for histopathological changes in the gastro-intestinal tract and for the delayed-type hypersensitivity reaction. The reproducibility of experiments with S. Enteritidis was good; in contrast, experiments with C. jejuni demonstrated poor reproducibility.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    RIVM
    Collections
    RIVM official reports

    entitlement

     

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.