Show simple item record

dc.contributor.authorStrik JJTWA
dc.contributor.authorDanse LHJC
dc.contributor.authorHelleman PW
dc.contributor.authorvan Leeuwen FXR
dc.contributor.authorSpeijers GJA
dc.contributor.authorVaessen HAMG
dc.date.accessioned2012-12-12T18:13:26Z
dc.date.available2012-12-12T18:13:26Z
dc.date.issued1986-06-30
dc.identifier618311001
dc.identifier.urihttp://hdl.handle.net/10029/259157
dc.description.abstractThe 4 week oral toxicity of propyl gallate in rats, exposed to 0, 1000, 5000 and 25000 mg/kg feed, was investigated. Parameters studied comprised growth, food and water intake, biochemistry, hematology, organ weights and histopathology. In the highest dose group both females and males gained less weight than those in the control group. Hemoglobin concentration, packed cell volume, red blood cell concentration, mean corpuscular volume and mean corpuscular hemoglobin were lowered in the highest dose group (males and females). In accordance with the anemia, an increased extramedullary hematopoiesis and slightly descreased hemosiderosis were noted in the spleen. In kidneys hyperplastic tubuli in the outer medulla were detected. In liver of the 5000 and 25000 mg/kg fed groups increases in activity of aminopyrin-N-demethylase and glucuronyltransferase and glutathione S-transferase and an increase in cytochrome P-450 content were detected. Based on these data a semi-chronic feeding study with a dose range of 1000-10000 mg propyl gallate/kg feed, and a detailed study into the mechanism of the hyperplastic tubular alterations in kidneys, are suggested.<br>
dc.description.sponsorshipHIL
dc.format.extent35 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618311001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618311001.html
dc.subject07nl
dc.subjectpropyl gallatenl
dc.subjectsubacutenl
dc.subjectoralnl
dc.subjectratsnl
dc.titleSubacute toxicity of propyl gallateen
dc.title.alternativeSubacute toxiciteit van propylgallaatnl
dc.typeReport
dc.date.updated2012-12-12T18:13:27Z
html.description.abstractThe 4 week oral toxicity of propyl gallate in rats, exposed to 0, 1000, 5000 and 25000 mg/kg feed, was investigated. Parameters studied comprised growth, food and water intake, biochemistry, hematology, organ weights and histopathology. In the highest dose group both females and males gained less weight than those in the control group. Hemoglobin concentration, packed cell volume, red blood cell concentration, mean corpuscular volume and mean corpuscular hemoglobin were lowered in the highest dose group (males and females). In accordance with the anemia, an increased extramedullary hematopoiesis and slightly descreased hemosiderosis were noted in the spleen. In kidneys hyperplastic tubuli in the outer medulla were detected. In liver of the 5000 and 25000 mg/kg fed groups increases in activity of aminopyrin-N-demethylase and glucuronyltransferase and glutathione S-transferase and an increase in cytochrome P-450 content were detected. Based on these data a semi-chronic feeding study with a dose range of 1000-10000 mg propyl gallate/kg feed, and a detailed study into the mechanism of the hyperplastic tubular alterations in kidneys, are suggested.&lt;br&gt;


This item appears in the following Collection(s)

Show simple item record