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dc.contributor.authorStruijs J
dc.contributor.authorBerg R van den
dc.date.accessioned2012-12-12T18:34:21Z
dc.date.available2012-12-12T18:34:21Z
dc.date.issued1992-07-31
dc.identifier679102012
dc.identifier.urihttp://hdl.handle.net/10029/259426
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractAssessing the risk of chemicals for the environment requires an estimation of degradation rates in order to evaluate a realistic exposure concentration for organisms. As QSAR's (quantitative structure activity relationships) for degradation are far from generally applicable, methods are proposed to extrapolate results obtained from standardized degradation tests to the most relevant environmental compartments. The design of the OECD laboratory test methods is such that, at least at the screening level, almost general applicability is achieved. Inevitably, tests conditions do not reflect biodegradation in the real world. However, if data are available on biodegradation it appears that fror most chemicals references are made to one of those standardized OECD methods. The Evaluation System New Chemicals is still lacking a systematical procedure to translate the result of an OECD test (or a combination of test results) to transformation rates under realistic circumstances. In this report a methodology is presented to evaluate standardized test results to rate constants for degradation in a biological wastewater treatment plant, surface water and aerobic soil. The extrapolation of a positive result in OECD screening tests relies a.o. on the assumption that the half-life is inversely proportional to the total concentration of micro-organisms. A first attempt was made to validate this extrapolation by comparing results of reported field studies on biodegradation of 20 chemicals with positive results in OECD Ready Biodegradability tests.
dc.description.sponsorshipDGM/SVS
dc.formatapplication/pdf
dc.format.extent18 p
dc.format.extent897 kb
dc.language.isoen
dc.relation.ispartofRIVM Rapport 679102012
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/679102012.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/679102012.pdf
dc.subject12nl
dc.subjectbiologische afbraaknl
dc.subjectsnelheidnl
dc.subjectbodemnl
dc.subjectoppervlaktewaternl
dc.subjecttestnl
dc.subjectafvalwaternl
dc.subjectzuiveringsinstallatienl
dc.subjecthalfwaardetijdnl
dc.subject92-3nl
dc.subjectoecdnl
dc.subjectextrapolationnl
dc.subjectqsarnl
dc.subjectbiodegradationen
dc.subjectvelocityen
dc.subjecttestingen
dc.subjectsoilen
dc.subjectsurface wateren
dc.subjectwaste water; halflifeen
dc.subjectpurificationen
dc.subjectsewage treatment plantsen
dc.titleDegradation rates in the environment: Extrapolation of standardized testsen
dc.title.alternativeAfbraaksnelheden in het milieu: Extrapolatie van gestandaardiseerde toetsennl
dc.typeReport
dc.date.updated2012-12-12T18:34:22Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractAssessing the risk of chemicals for the environment requires an estimation of degradation rates in order to evaluate a realistic exposure concentration for organisms. As QSAR's (quantitative structure activity relationships) for degradation are far from generally applicable, methods are proposed to extrapolate results obtained from standardized degradation tests to the most relevant environmental compartments. The design of the OECD laboratory test methods is such that, at least at the screening level, almost general applicability is achieved. Inevitably, tests conditions do not reflect biodegradation in the real world. However, if data are available on biodegradation it appears that fror most chemicals references are made to one of those standardized OECD methods. The Evaluation System New Chemicals is still lacking a systematical procedure to translate the result of an OECD test (or a combination of test results) to transformation rates under realistic circumstances. In this report a methodology is presented to evaluate standardized test results to rate constants for degradation in a biological wastewater treatment plant, surface water and aerobic soil. The extrapolation of a positive result in OECD screening tests relies a.o. on the assumption that the half-life is inversely proportional to the total concentration of micro-organisms. A first attempt was made to validate this extrapolation by comparing results of reported field studies on biodegradation of 20 chemicals with positive results in OECD Ready Biodegradability tests.


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