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    De allergene potentie van geneesmiddelen: literatuurstudie

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    Authors
    van Amsterdam JGC
    Vleeming W
    de Wildt DJ
    van der Laan JW
    de Waal EJ
    van Loveren H
    Garssen J
    Type
    Report
    Language
    nl
    
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    Title
    De allergene potentie van geneesmiddelen: literatuurstudie
    Translated Title
    Allergic potency of drugs: a review of literature
    Publiekssamenvatting
    Dit rapport geeft een overzicht van de allergische reacties, die het gevolg zijn van geneesmiddelengebruik. De nadruk is gelegd op ernstige allergische reacties. Een overzicht -ingedeeld volgens de classificatie van Gell en Coombs wordt gegeven van geneesmiddelen met een allergene potentie. Daarnaast worden in een apart hoofdstuk enkele geneesmiddelen beschreven geselecteerd met ernstige of frequente allergische reacties. Voorts wordt ingegaan op de diagnostische mogelijkheden en de daarmee samenhangende problematiek ten einde de grote individuele variatie m.b.t. de gevoeligheid voor geneesmiddelen te schetsen. Tenslotte wordt een kort overzicht gegeven van diermodellen, waarin geneesmiddel-geinduceerde allergische reacties bestudeerd kunnen worden.<br>
    This report reviews drug-induced allergic reactions with emphasis on the most serious allergic reactions. The allergic potency of drugs has been outlined in a general way using classification of Gell and Coombs. In addition, specific drugs with severe or frequent allergic side-effects have been selected and described in a separate section. This report also summarizes the available diagnostic tests and its specific problems regarding interindividual variation in susceptibility for allergic drug reactions. Finally, several animal testmodels are reviewed which can be used to determine the allergic potential of drugs.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    CBG
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