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    CONSEXPO 2: Consumer Exposure and Uptake Models

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    Authors
    Veen MP van
    Type
    Report
    Language
    en
    
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    Title
    CONSEXPO 2: Consumer Exposure and Uptake Models
    Translated Title
    CONSEXPO 2: Consumenten Blootstelling en Opnamemodellen
    Publiekssamenvatting
    Het programma en de achtergronden in het rapport zijn bedoeld voor de blootstellingsschatting van chemische stoffen in consumentenproducten. Consumentenproducten omvatten een grote diversiteit aan producten, daaronder vallen ook detergenten en pesticiden. Al deze producten bevatten mogelijkerwijs gevaarlijke stoffen, zowel actieve ingredienten als verontreinigingen. Een blootstellingsschatting omvat meer dan het meten van productconcentraties. Stoffen komen in de lucht of in het water en producten worden mogelijk verdund. Ook de duur van contact en de verblijftijd in huis bepalen de blootstelling. Het onderliggende rapport bevat een modelmatige benadering, gebaseerd op contact-, blootstellings- en opnamemodellen. Voor elke blootstellingsroute zijn mathematische modellen aanwezig. Een algemeen raamwerk verbindt de modellen zoals ze door een gebruiker geselecteerd zijn. In het programma kunnen ook stochastische parameters gegeven worden die verdelingen van blootstelling en opname opleveren, hieruit kan een willekeurig percentiel opgevraagd worden. Het programma is verbonden met een database, waarin voorgedefinieerde blootstellings- en opnamescenarios komen te staan.
    The program and manual described in this report are aimed at exposure assessment of chemical compounds contained in consumer products. Consumer products are highly diverse, ranging from shoe polish to detergents to pesticides. All these products may contain hazardous compounds, both as active ingredients and as contaminants. Assessing exposure to these products amounts to more than measuring product concentrations. Compounds are released into air or water during use and the concentration of products may be diluted; these are factors determining the exposure. The duration of use and residence times in a room or house also determine the exposure. A mathematical modelling approach based on contact, exposure and uptake models is presented here. Each route of exposure includes a number of exposure and uptake models. The separate exposure and uptake models are connected in a general framework according to how they are selected by the user. The program allows use of stochastic parameters, including variability and uncertainty, to calculate the resulting exposure and uptake distributions, allowing any percentile whatsoever to be calculated. This program is linked to a database in which predefined exposure and uptake models for product categories will be taken up.
    Description
    Programma en print niet meer beschikbaar / Program and print out of order. Zie versie 3 / See release 3.0 - 612810011
    Sponsors
    IGB
    URI
    http://hdl.handle.net/10029/259539
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