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dc.contributor.authorVoogd CE
dc.contributor.authorStel JJ van der
dc.contributor.authorBruchem MC van
dc.contributor.authorStavenuiter JFC
dc.date.accessioned2012-12-12T18:57:16Z
dc.date.available2012-12-12T18:57:16Z
dc.date.issued1992-05-31
dc.identifier658804004
dc.identifier.urihttp://hdl.handle.net/10029/259698
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractThe mutagenic activity of 4-aminobiphenyl and 4-amino-3-methylbiphenyl was investigated in the Amestest, Salmonella typhimurium strains TA100 and TA98 were used. 4-N-acetylaminobiphenyl and 4-N-acetylamino-3- methylbiphenyl were not mutagenic (or weakly). 4-Amonibiphenyl, 4-amino-3-methyl-biphenyl, 4-acetoxy-acetylaminobiphenyl, 4-N-hydroxy-N-acetylaminobiphenyl and 4-N-hydroxy-N-acetylamino- 3-methylbiphenyl were mutagenic in the presence of metabolic activation. With 4-hydroxylaminobiphenyl, 3-methyl-4-hydroxylaminobiphenyl and 3-methyl-4-acetoxy-acetylaminobiphenyl a mutagenic activity was found in the presence and absence of metabolic activation. With 4-nitrobiphenyl and 3-methyl-4-nitrobiphenyl a mutagenic activity was found without metabolic activation. The obtained results point to the hydroxylamino derivatives as being the ultimate mutagenic derivatives of 4-aminobiphenyl and 4-amino-3-methylbiphenyl.
dc.description.sponsorshipHIGB
dc.format.extent59 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 658804004
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/658804004.html
dc.subject07nl
dc.subjectvoedingnl
dc.subjectaminennl
dc.subjectstofwisselingnl
dc.subjectmutageniteitnl
dc.subjectmutageniteitstestennl
dc.subjectmicroorganismennl
dc.subjectfooden
dc.subjectaminesen
dc.subjectmetabolismen
dc.subjectmutagenicity testingen
dc.subjectmicroorganismsen
dc.titleOnderzoek naar de mutagene werking van 4-amino-bifenyl en van enkele intermediairen van de stofwisseling alsmede enkele 3-methylderivaten op microorganismennl
dc.title.alternativeThe mutagenic activity of 4-amino-biphenyl and some intermediaries of metabolism and some 3-methyl-derivatives on micro-organismsen
dc.typeReport
dc.date.updated2012-12-12T18:57:16Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractThe mutagenic activity of 4-aminobiphenyl and 4-amino-3-methylbiphenyl was investigated in the Amestest, Salmonella typhimurium strains TA100 and TA98 were used. 4-N-acetylaminobiphenyl and 4-N-acetylamino-3- methylbiphenyl were not mutagenic (or weakly). 4-Amonibiphenyl, 4-amino-3-methyl-biphenyl, 4-acetoxy-acetylaminobiphenyl, 4-N-hydroxy-N-acetylaminobiphenyl and 4-N-hydroxy-N-acetylamino- 3-methylbiphenyl were mutagenic in the presence of metabolic activation. With 4-hydroxylaminobiphenyl, 3-methyl-4-hydroxylaminobiphenyl and 3-methyl-4-acetoxy-acetylaminobiphenyl a mutagenic activity was found in the presence and absence of metabolic activation. With 4-nitrobiphenyl and 3-methyl-4-nitrobiphenyl a mutagenic activity was found without metabolic activation. The obtained results point to the hydroxylamino derivatives as being the ultimate mutagenic derivatives of 4-aminobiphenyl and 4-amino-3-methylbiphenyl.


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