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dc.contributor.authorFeskens EJM
dc.contributor.authorSeidell JC
dc.contributor.authorWiertz EJHJ
dc.date.accessioned2012-12-12T19:01:51Z
dc.date.available2012-12-12T19:01:51Z
dc.date.issued1993-09-30
dc.identifier263710001
dc.identifier.urihttp://hdl.handle.net/10029/259772
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractRecent developments in molecular biology have stimulated research into the genetic basis of human diseases. At first, most attention was focussed at monogenetic diseases. However, especially chronic diseases such as cardiovascular diseases and diabetes mellitus are important from a public health point of view: the number of patients is large, rates increase with aging of the population, mortality is high, as are the health care costs. Until now, the incidence of these diseases can only be explained for a 50% at maximum. The remaining percentage can probably be explained by still unknown factors, of which genetic factors seem to be the most important. Cardiovascular disease and diabetes are both chronic diseases, with a multifactorial origin. Insight into the genetic basis of these diseases and the way genetic information is expressed and revealed by environmental and lifestyle factors, is of main importance for the future prevention of these disorders. In this overview attention was paid to the process of atherosclerosis, and to the development of type 1 and type 2 diabetes mellitus. It is clear that studies should first focus on the biological intermediates of these processes. From the literature study it appears that studies into the genetics of lipoprotein metabolism may be especially fruitful regarding atherosclerosis. There are sufficient possibilities to study the interaction with lifestyle factors such as diet.
dc.description.sponsorshipDGVGZ/PAO Smid HJ
dc.format.extent44 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 263710001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/263710001.html
dc.subject04nl
dc.subjecthartziektennl
dc.subjectvaatziektennl
dc.subjectdiabetes mellitusnl
dc.subjectgeneticanl
dc.subjectepidemiologienl
dc.subjectcardiovascular diseasesen
dc.subjectdiabetes mellitusen
dc.subjectgeneticsen
dc.subjectepidemiologyen
dc.subjecthart- en vaatziektenen
dc.subjectdiabetesen
dc.subjectgeneticaen
dc.subjectepidemiologieen
dc.subjectimmunogeneticaen
dc.titleErfelijke factoren voor hart- en vaatziekten en diabetes mellitus: een inventarisatienl
dc.title.alternative[Genetic factors for cardiovascular diseases and diabetes mellitus: an overview.]en
dc.typeReport
dc.date.updated2012-12-12T19:01:52Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractRecent developments in molecular biology have stimulated research into the genetic basis of human diseases. At first, most attention was focussed at monogenetic diseases. However, especially chronic diseases such as cardiovascular diseases and diabetes mellitus are important from a public health point of view: the number of patients is large, rates increase with aging of the population, mortality is high, as are the health care costs. Until now, the incidence of these diseases can only be explained for a 50% at maximum. The remaining percentage can probably be explained by still unknown factors, of which genetic factors seem to be the most important. Cardiovascular disease and diabetes are both chronic diseases, with a multifactorial origin. Insight into the genetic basis of these diseases and the way genetic information is expressed and revealed by environmental and lifestyle factors, is of main importance for the future prevention of these disorders. In this overview attention was paid to the process of atherosclerosis, and to the development of type 1 and type 2 diabetes mellitus. It is clear that studies should first focus on the biological intermediates of these processes. From the literature study it appears that studies into the genetics of lipoprotein metabolism may be especially fruitful regarding atherosclerosis. There are sufficient possibilities to study the interaction with lifestyle factors such as diet.


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