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dc.contributor.authorVaal MA
dc.contributor.authorBreedijk I
dc.contributor.authorDekker MP
dc.contributor.authorMout HCA
dc.contributor.authorKramers PGN
dc.contributor.authorRoghair CJ
dc.date.accessioned2017-02-20T07:13:48
dc.date.issued1992-12-31
dc.identifier719102021
dc.description.abstractDaphnia magna is used as a model organism to study the consequences of the impact of mutagenic chemicals to natural populations. Adult daphnids were exposed to a mutagenic test compound to test whether their offspring showed effects of induced mutations at exposure levels lower than the No Observed Effect Concentration for growth and reproduction. Life-history parameters were used as test parameters. A concentration-related toxic effect to reproduction could be measured reproducibly in the exposed adult daphnids. However, no indication of a mutagenic effect could be detected in their offspring. This may have been due to the inadequateness of the system to detect induced genetic change.<br>
dc.description.sponsorshipDGM/SVS
dc.description.sponsorshipSTIMTOX
dc.format.extent38 p
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 719102021
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/719102021.html
dc.subject07nl
dc.subjectmutageniteitnl
dc.subjecttoxische stoffennl
dc.subjectecotoxicologienl
dc.subjectvoortplantingnl
dc.subjectdosis-effectrelatienl
dc.subjectnelnl
dc.subjecttoetsorganismenl
dc.subjectwatervlooiennl
dc.subjectmutagenicityen
dc.subjecttoxic substancesen
dc.subjectecotoxicologyen
dc.subjectreproductionen
dc.subjectdose effect relationen
dc.subjectnelen
dc.subjectmonitoring organismsen
dc.subjectdaphniaen
dc.subjectlife-history parametersen
dc.titleMutagene stoffen en risico&apos;s voor natuurlijke populaties. Onderzoek met Daphnia magna als modelorganisme. II. Experimenten met een mutagene stofnl
dc.title.alternative[Mutagenic substances and natural populations at risk. Research with Daphnia magna as a model organism. II. Experiments with a mutagenic substance.]en
dc.typeReport
dc.date.updated2017-02-20T06:13:48Z
html.description.abstractDaphnia magna is used as a model organism to study the consequences of the impact of mutagenic chemicals to natural populations. Adult daphnids were exposed to a mutagenic test compound to test whether their offspring showed effects of induced mutations at exposure levels lower than the No Observed Effect Concentration for growth and reproduction. Life-history parameters were used as test parameters. A concentration-related toxic effect to reproduction could be measured reproducibly in the exposed adult daphnids. However, no indication of a mutagenic effect could be detected in their offspring. This may have been due to the inadequateness of the system to detect induced genetic change.&lt;br&gt;


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