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dc.contributor.authorJansen EHJM
dc.contributor.authorvan den Ham WA
dc.contributor.authorde Fluiter P
dc.contributor.authorvan Leeuwen FXR
dc.date.accessioned2014-01-17T13:40:00
dc.date.issued1993-06-30
dc.identifier618902014
dc.description.abstractIn a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg di(2-ethylhexyl)adipate (DEHA)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the liver weight. The highest dose group showed a significant decrease in the body weight. PCO, CAT and LAH showed no effect up to 2000 mg DEHA/kg diet. ECH, an enzyme involved in the beta-oxidation, was more sensitive with a dose-without-effect (DWE) of 200 mg DEHA/kg diet. Therefore an overall no-observed-effect-level of 200 mg DEHA/KG diet was defined equal to 20.1 mg DEHA/kg b.w.day.<br>
dc.description.sponsorshipHIGB
dc.format.extent34 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618902014
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902014.html
dc.subject07nl
dc.subjectdi(2-ethylhexyl)adipatenl
dc.subjecttoxiciteitstestnl
dc.subjectdierproevennl
dc.subjectenzymennl
dc.subjectdi(2-ethylhexyl)adipateen
dc.subjecttoxicity testingen
dc.subjectnelen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.subjectdi(2-ethylhexyl)adipateen
dc.subjectdehaen
dc.subjectpalmitoyl coenzyme-a oxidaseen
dc.subjectpcoen
dc.subjectenoyl coenzyme-a hydrataseen
dc.subjectechen
dc.subjectcarnitine acetyl transferaseen
dc.subjectcaten
dc.subjectlauric acid hydroxylaseen
dc.subjectlahen
dc.subjectliver homogenatesen
dc.titleToxicological investigation of di(2-ethylhexyl)adipate in ratsen
dc.title.alternative[Toxicologisch onderzoek van di(2-ethylhexyl)adipaat in ratten.]nl
dc.typeReport
dc.date.updated2014-01-17T12:42:18Z
html.description.abstractIn a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg di(2-ethylhexyl)adipate (DEHA)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the liver weight. The highest dose group showed a significant decrease in the body weight. PCO, CAT and LAH showed no effect up to 2000 mg DEHA/kg diet. ECH, an enzyme involved in the beta-oxidation, was more sensitive with a dose-without-effect (DWE) of 200 mg DEHA/kg diet. Therefore an overall no-observed-effect-level of 200 mg DEHA/KG diet was defined equal to 20.1 mg DEHA/kg b.w.day.&lt;br&gt;


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