• Login
    View Item 
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    RIVM Publications RepositoryCommunitiesTitleAuthorsIssue DateSubmit Date

    My Account

    LoginRegister

    Statistics

    Display statistics

    Evaluatie van de AutoDELFIA Neonatal 17alpha-OH-Progesteron kit voor de pilot-screening op het adrenogenitaal syndroom (AGS)

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Elvers LH
    Loeber JG
    van Duin S
    Verheul FEAM
    Type
    Report
    Language
    nl
    
    Metadata
    Show full item record
    Title
    Evaluatie van de AutoDELFIA Neonatal 17alpha-OH-Progesteron kit voor de pilot-screening op het adrenogenitaal syndroom (AGS)
    Translated Title
    Evaluation of the AutoDELFIA Neonatal 17alpha-OH-Progesterone kit for the pilot-screening for the congenital adrenal hyperplasia
    Publiekssamenvatting
    Op 1 januari 1998 is een door het Praeventiefonds gesubsidieerd project gestart, om na te gaan of het zinvol is om pasgeborenen te screenen op het adrenogenitaal syndroom (AGS), een ernstige autosomaal recessieve ziekte. Deze pilotscreening zal twee jaar duren en wordt uitgevoerd in de regio's Midden- (Utrecht en Gelderland) en Zuid-West Nederland (Zeeland en Zuid Holland). Bij de screening wordt 17alpha-hydroxyprogesteron (17OHP) bepaald in hetzelfde monster hielprikbloed dat voor de screening op phenylketonurie (PKU) en congenitale hypothyreoidie (CHT) wordt afgenomen. Voor de bepaling wordt gebruik gemaakt van de AutoDELFIA-methode voor 17OHP. De evaluatie van deze methode is in dit rapport beschreven. In 993 hielprikmonsters van neonaten zonder AGS werd de 17OHP concentratie bepaald. De gemeten 17OHP-concentratie bleek bij prematuren afhankelijk van geboortegewicht en/of zwangerschapsduur. Op grond hiervan werden geboortegewicht- en zwangerschapsduur-afhankelijke afkapgrenzen vastgesteld, waarboven een gemeten 17OHP concentratie als afwijkend wordt beschouwd. De terugwinning van toegevoegd 17OHP in kwaliteitscontrolemonsters van het Centres for Disease Control and Prevention bedroeg 86 +- 7% ten opzichte van het 'all laboratories trimmed mean' (ALTM) en 97 +- 10% ten opzichte van de toevoeging. De variatie coefficient binnen- en tussen meetsessies was 6-12% respectievelijk 6-10%. Conclusie: de AutoDELFIA is een geschikte methode voor de bepaling van 17OHP in hielprikbloed.<br>
    On January 1st, 1998 a pilot has started to study the possibilities for screening on congenital adrenal hyperplasia (CAH) in the Netherlands. CAH , in the Netherlands called adrenal genital syndrome (AGS), is a severe autosomal recessive illness. The pilot will take two years and will be carried out in the provinces Utrecht, Gelderland, Zeeland and Zuid-Holland. 17alpha-Hydroxyprogesterone (17OHP) will be determined with the AutoDELFIA method (Wallac Oy, Turku, Finland) in the same dried bloodspots which are collected for the PKU/CHT screening. This report describes the results of the evaluation of this method. 17OHP was measured in 993 bloodspot samples from neonates without CAH and in 14 bloodspot samples from CAH-patients. For premature infants a negative correlation was found between the 17OHP concentration and birthweight or gestational age, respectively. Decision limits, depending on birthweight and gestational age, were calculated. The recovery for 17OHP in quality control samples obtained from Centres for Disease Control and Prevention was 86 +- 7% compared with the all laboratories trimmed mean (ALTM), and 97 +- 10% compared with the amount 17OHP added to the samples. The within- and between assay coefficient of variation was 6-12% and 6-10%, respectively. Conclusion: the AutoDELFIA is a reliable method for the determination of 17OHP in dried bloodspots.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    IGZ
    URI
    http://hdl.handle.net/10029/260545
    Collections
    RIVM official reports

    entitlement

     

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.