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    Tetrahydrobiopterine als mogelijke mediator in septische shock

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    Authors
    van Amsterdam JGC
    Eigeman L
    van de Kuil A
    te Biesebeek JD
    Wemer J
    Type
    Report
    Language
    nl
    
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    Title
    Tetrahydrobiopterine als mogelijke mediator in septische shock
    Translated Title
    [Tetrahydrobiopterin as putative mediator in septic shock.]
    Publiekssamenvatting
    Enhanced serum levels neopterin are associated with various immune-related diseases like septic shock and vascular leakage syndrome. Tetrahydrobiopterin (THB, 100 muM) but not bioterin induces appreciable endothelium-dependent vasodilatation and enhances cGMP-level (95% increase) to the same extent as arecoline. NG-methyl-L-arginine (L-NAME) does not antagonize the tetrahydrobiopterin effects. In addition, tetrahydrobiopterin enhances cGMP-level in tracheal smooth muscle (+28%) and artery pulmonalis (+57%). Present results show that tetrahydrobiopterin being precursor of biopterin and co-factor of NO-synthase, induces vasodilatation by increasing intracellular cyclic GMP level and suggest a prominent role for tetrahydrobiopterin in immune-triggered hypotension.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    GHI
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