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dc.contributor.authorvan Amsterdam JGC
dc.contributor.authorEigeman L
dc.contributor.authorvan de Kuil A
dc.contributor.authorte Biesebeek JD
dc.contributor.authorWemer J
dc.date.accessioned2013-11-21T11:07:31
dc.date.issued1994-01-31
dc.identifier319004001
dc.description.abstractEnhanced serum levels neopterin are associated with various immune-related diseases like septic shock and vascular leakage syndrome. Tetrahydrobiopterin (THB, 100 muM) but not bioterin induces appreciable endothelium-dependent vasodilatation and enhances cGMP-level (95% increase) to the same extent as arecoline. NG-methyl-L-arginine (L-NAME) does not antagonize the tetrahydrobiopterin effects. In addition, tetrahydrobiopterin enhances cGMP-level in tracheal smooth muscle (+28%) and artery pulmonalis (+57%). Present results show that tetrahydrobiopterin being precursor of biopterin and co-factor of NO-synthase, induces vasodilatation by increasing intracellular cyclic GMP level and suggest a prominent role for tetrahydrobiopterin in immune-triggered hypotension.<br>
dc.description.sponsorshipGHI
dc.format.extent20 p
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 319004001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/319004001.html
dc.subject03nl
dc.subjectseptische shocknl
dc.subjectbloeddruknl
dc.subjectseptic shocken
dc.subjectblood pressureen
dc.subjecttetrahydrobiopterinen
dc.subjectneopterinen
dc.subjecttetrahydrobiopterineen
dc.subjectneopterineen
dc.subjectcytidine cyclic monophosphateen
dc.subjectcgmpen
dc.subjectno-synthaseen
dc.titleTetrahydrobiopterine als mogelijke mediator in septische shocknl
dc.title.alternative[Tetrahydrobiopterin as putative mediator in septic shock.]en
dc.typeOnderzoeksrapport
dc.date.updated2013-11-21T10:07:32Z
html.description.abstractEnhanced serum levels neopterin are associated with various immune-related diseases like septic shock and vascular leakage syndrome. Tetrahydrobiopterin (THB, 100 muM) but not bioterin induces appreciable endothelium-dependent vasodilatation and enhances cGMP-level (95% increase) to the same extent as arecoline. NG-methyl-L-arginine (L-NAME) does not antagonize the tetrahydrobiopterin effects. In addition, tetrahydrobiopterin enhances cGMP-level in tracheal smooth muscle (+28%) and artery pulmonalis (+57%). Present results show that tetrahydrobiopterin being precursor of biopterin and co-factor of NO-synthase, induces vasodilatation by increasing intracellular cyclic GMP level and suggest a prominent role for tetrahydrobiopterin in immune-triggered hypotension.&lt;br&gt;


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