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dc.contributor.authorOostvogel PM
dc.contributor.authorRobertson SE
dc.contributor.authorSutter RW
dc.contributor.authorLoon AM van
dc.date.accessioned2012-12-12T21:10:39Z
dc.date.available2012-12-12T21:10:39Z
dc.date.issued1993-07-31
dc.identifier242500001
dc.identifier.urihttp://hdl.handle.net/10029/260711
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractThe development of mucosal immunity (MI) is very important for reducing the replication and circulation of the virus, and thereby, for the control and eradication of poliomyelitis. Both the inactivated (IPV) and oral (OPV) poliomyelitis vaccine induce a MI to some degree. The MI induced by OPV resembles that obtained after natural infection. It does not confer absolute immunity to reinfection ; around 35% of OPV-vaccinees excrete virus after challenge with OPV. The MI induced by IPV is less effective. Nevertheless, the magnitude and duration of virusexcretion are considerably reduced compared with non vaccinated controls. The differences in MI between IPV and OPV vaccinees are most outspoken in the gut and less so in the pharinx. So far, studies on MI mainly focussed on poliovirus type 1, used vaccines (-formulations) different from those used in the Netherlands and were carried out shortly after vaccination. Hardly any data exist on the persistance of MI, as well on MI induced by combined IPV and OPV schemes. Although apparently less effective in inducing MI, the use of IPV has stopped endemic viruscirculation in countries like Sweden and the Netherlands. The reason for this is not quite clear and further indicate that the results of the (mostly experimental) studies on MI cannot simply be extrapolated to the current Dutch situation. Further studies are needed to determine the extent and significance of MI in the Dutch population.
dc.description.sponsorshipGHI
dc.format.extent27 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 242500001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/242500001.html
dc.subject02nl
dc.subjectpoliovaccinnl
dc.subjectoraal poliovaccinnl
dc.subjectgeinactiveerd poliovaccinnl
dc.subjectvaccinatienl
dc.subjectimmuniteitnl
dc.subjectpoliovirus vaccineen
dc.subjectvaccinationen
dc.subjectimmunityen
dc.subjectoral poliovirus vaccineen
dc.titlePoliovirus-specifieke mucosale immuniteit: Een overzicht van de literatuurnl
dc.title.alternative[Poliovirus-specific mucosal immunity: A literature review.]en
dc.typeReport
dc.date.updated2012-12-12T21:10:40Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractThe development of mucosal immunity (MI) is very important for reducing the replication and circulation of the virus, and thereby, for the control and eradication of poliomyelitis. Both the inactivated (IPV) and oral (OPV) poliomyelitis vaccine induce a MI to some degree. The MI induced by OPV resembles that obtained after natural infection. It does not confer absolute immunity to reinfection ; around 35% of OPV-vaccinees excrete virus after challenge with OPV. The MI induced by IPV is less effective. Nevertheless, the magnitude and duration of virusexcretion are considerably reduced compared with non vaccinated controls. The differences in MI between IPV and OPV vaccinees are most outspoken in the gut and less so in the pharinx. So far, studies on MI mainly focussed on poliovirus type 1, used vaccines (-formulations) different from those used in the Netherlands and were carried out shortly after vaccination. Hardly any data exist on the persistance of MI, as well on MI induced by combined IPV and OPV schemes. Although apparently less effective in inducing MI, the use of IPV has stopped endemic viruscirculation in countries like Sweden and the Netherlands. The reason for this is not quite clear and further indicate that the results of the (mostly experimental) studies on MI cannot simply be extrapolated to the current Dutch situation. Further studies are needed to determine the extent and significance of MI in the Dutch population.


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