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    Onderzoek naar de mutagene werking van butylhydroxyanisool en verhit butylhydroxyanisool met bacterien

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    Authors
    Voogd CE
    van der Stel JJ
    Verharen HW
    Type
    Report
    Language
    nl
    
    Metadata
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    Title
    Onderzoek naar de mutagene werking van butylhydroxyanisool en verhit butylhydroxyanisool met bacterien
    Translated Title
    Investigation of the mutagenicity of butylhydroxyanisole and heated butylhydroxyanisole on bacteria
    Publiekssamenvatting
    Met onverhit butylhydroxyanisool (BHA) is geen mutagene werking gevonden in de fluctuatietest op Klebsiella pneumoniae bij 0,1 g BHA per liter of lagere concentraties. Met onverhit BHA werd bij 2 mg of minder per selectieplaat geen mutagene werking gevonden met de Salmonella typhimurium stammen TA 90, TA 98 en TA 100. Met onder verschillende omstandigheden verhit BHA - in maisolie, dimethylsulfoxyde of droog gedurende maximaal 7 uur bij 100 graden C of in maisolie gedurende 4 uur bij 150 graden C of 20 minuten bij 120 graden C - werd geen mutagene werking op de Salmonella typhimurium stammen TA 90, TA 98 en TA 100 gevonden. Bij droge verhitting (100 graden C) of verhitting in dimethylsulfoxide (100 graden C) werden groeiremmende stoffen gevormd, waardoor van onder deze condities verhit BHA maximaal 0,1 mg per selectieplaat kon worden onderzocht op mutagene werking.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    RIVM
    URI
    http://hdl.handle.net/10029/260722
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