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    Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment - Part IV

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    Authors
    Smit CE
    van Raaij MTM
    Series/Report no.
    RIVM Rapport 601516012
    Type
    Onderzoeksrapport
    Language
    en
    
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    Title
    Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment - Part IV
    Translated Title
    Factsheets voor de (eco)toxicologische risicobeoordelingsstrategie bij het Rijksinstituut voor Volksgezondheid en Milieu - Deel IV
    Publiekssamenvatting
    Dit rapport bundelt twee factsheets waarin methodieken worden beschreven die worden gebruikt voor de risicobeoordeling van stoffen bij het Centrum voor Stoffen en Integrale Risicobeoordeling (SIR) van het Rijksinstituut voor Volksgezondheid en Milieu (RIVM). Het voornaamste doel is om de inzichtelijkheid en eenduidigheid van de bij RIVM-SIR gevolgde methodieken te vergroten. De factsheets over voormaagtumoren en Leydigcel tumoren beschrijven de mechanistische aspecten van de tumorvorming en gaan in op de verschillen in anatomie, fysiologie en blootstelling tussen knaagdieren en mensen. Er wordt een raamwerk geboden voor het evalueren van de relevantie van deze tumoren voor de humane risicobeoordeling. De factsheets vormen de weerslag van de huidige stand van wetenschap. Ze zijn bedoeld om de discussie met andere (inter)nationale partijen op het gebied van risicobeoordeling te bevorderen.

    This report contains two factsheetsdescribing risk assessment methods used at the Centre for Substances and Integral Risk Assessment (SIR) of the National Institute for Public Health and the Environment (RIVM). The main aim is to enhance transparency and consistency in the risk assessment methods used at SIR-RIVM. The factsheets on forestomach tumours and Leydigcell tumours describe the mechanistic aspects involved in tumour formation, as well as the similarities and differences in anatomy, physiology and exposure conditions between rodents and humans. An approach is presented to evaluate the relevance of these types of tumours for human risk assessment. The two factsheets reflect a state-of-the-art approach and are meant to facilitate discussion with other national and international parties involved in risk assessment.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    RIVM
    URI
    http://hdl.handle.net/10029/260829
    Collections
    RIVM official reports

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