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    Methods and testing strategies for evaluating the genotoxic properties of chemicals

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    Authors
    Mohn GR
    Carere A
    Parry JM
    Sors AI
    Nolan CV
    Type
    Report
    Language
    en
    
    Metadata
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    Title
    Methods and testing strategies for evaluating the genotoxic properties of chemicals
    Publiekssamenvatting
    Abstract niet beschikbaar
    Current methods and testing strategies for evaluating the genotoxic effects of chemicals are reviewed. Following an overview of both somatic and germ cell mutagenesis, model organisms and tests in current use are described. Correlations of short-term tests with carcinogenicity and germ cell mutagenicity data are assessed and the two main genotoxicity testing strategies - the tier approach and the battery approach - are described. Guidelines currently recommended at international (CEC and OECD), national (the UK, Italy, Japan, Canada, and the U.S.A.), and industry (European Chemical Industry Ecology and Toxicology Centre) levels are described. It is concluded that, given technological progress, there is scope for improvement of current practices and methodologies. Recommendations for future research and development are given both for in-vitro and in-vivo genotoxicity tests and for ecosystems and environmental compartments.
    Description
    not available at RIVM
    Sponsors
    EU
    MAP-M
    DGM
    URI
    http://hdl.handle.net/10029/260858
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