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dc.contributor.authorMohn GR
dc.contributor.authorCarere A
dc.contributor.authorParry JM
dc.contributor.authorSors AI
dc.contributor.authorNolan CV
dc.date.accessioned2012-12-12T21:22:52Z
dc.date.available2012-12-12T21:22:52Z
dc.date.issued1995-12-31
dc.identifier659101005
dc.identifier.isbn928270081x
dc.identifier.urihttp://hdl.handle.net/10029/260858
dc.descriptionnot available at RIVMen
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractCurrent methods and testing strategies for evaluating the genotoxic effects of chemicals are reviewed. Following an overview of both somatic and germ cell mutagenesis, model organisms and tests in current use are described. Correlations of short-term tests with carcinogenicity and germ cell mutagenicity data are assessed and the two main genotoxicity testing strategies - the tier approach and the battery approach - are described. Guidelines currently recommended at international (CEC and OECD), national (the UK, Italy, Japan, Canada, and the U.S.A.), and industry (European Chemical Industry Ecology and Toxicology Centre) levels are described. It is concluded that, given technological progress, there is scope for improvement of current practices and methodologies. Recommendations for future research and development are given both for in-vitro and in-vivo genotoxicity tests and for ecosystems and environmental compartments.
dc.description.sponsorshipEU
dc.description.sponsorshipMAP-M
dc.description.sponsorshipDGM
dc.format.extent98 p
dc.language.isoen
dc.relation.ispartofRIVM Rapport 659101005 , EUR 15945 EN
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/659101005.html
dc.subject03nl
dc.subjectchemicalsen
dc.subjecthealth effectsen
dc.subjecttoxicity testingen
dc.subjectmutagenicity testingen
dc.subjectcarcinogenicity testingen
dc.titleMethods and testing strategies for evaluating the genotoxic properties of chemicalsen
dc.typeReport
dc.contributor.departmentLCM
dc.date.updated2012-12-12T21:22:53Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractCurrent methods and testing strategies for evaluating the genotoxic effects of chemicals are reviewed. Following an overview of both somatic and germ cell mutagenesis, model organisms and tests in current use are described. Correlations of short-term tests with carcinogenicity and germ cell mutagenicity data are assessed and the two main genotoxicity testing strategies - the tier approach and the battery approach - are described. Guidelines currently recommended at international (CEC and OECD), national (the UK, Italy, Japan, Canada, and the U.S.A.), and industry (European Chemical Industry Ecology and Toxicology Centre) levels are described. It is concluded that, given technological progress, there is scope for improvement of current practices and methodologies. Recommendations for future research and development are given both for in-vitro and in-vivo genotoxicity tests and for ecosystems and environmental compartments.


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