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dc.contributor.authorEmans HJB
dc.contributor.authorOkkerman PC
dc.contributor.authorPlassche EJ van de
dc.contributor.authorSparenburg PM
dc.contributor.authorCanton JH
dc.date.accessioned2012-12-12T21:36:45Z
dc.date.available2012-12-12T21:36:45Z
dc.date.issued1992-07-31
dc.identifier679102014
dc.identifier.urihttp://hdl.handle.net/10029/261010
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractFor effects assessment several extrapolation methods can be used to derive the concentration of toxic chemicals above which adverse effects on terrestrial or aquatic ecosystems may occur. These methods are based on single species toxicity data. At present, however, it is uncertain whether the values calculated with these extrapolation methods really represent accurate estimations of concentrations harmless to ecosystems. Therefore a validation of extrapolation methods was carried out by comparing No Observed Effect Concentrations derived from multiple species (semi-) field experiments with extrapolated values. In this study validation was restricted to the methods of Aldenberg & Slob (1991) and Wagner & Lokke (1991) and a modification of the method of the United States Environmental Protection Agency (OECD, 1991). Multiple species experiments for organic compounds and metals in aquatic ecosystems were studied. For only 29 compounds, 19 organic compounds and 10 metals, one or more multiple species NOECs could be derived. For 11 of these compounds, an insufficient number of single species toxicity data was available to apply the methods of Aldenberg & Slob and Wagner & Lokke. With reservations, due to the paucity of data, it is concluded that single species toxicity data can be used to derive "safe" values for the aquatic ecosystem. Furthermore, extrapolation methods seem to be a good basis for determining these values. Based on the results of this study the best correlation between MS NOECs and extrapolated values can be obtained with the methods of Aldenberg & Slob and Wagner & Lokke, both with a 95& protection level and a 50% confidence level.
dc.description.sponsorshipDGM/SVS
dc.format.extent38 p
dc.language.isoen
dc.relation.ispartofRIVM Rapport 679102014
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/679102014.html
dc.subject07nl
dc.subject92-3nl
dc.subjectextrapolatie methodennl
dc.subjectvalidatienl
dc.subjectmultipele species experimenten; aquatische ecosystemennl
dc.subjectsingle species datanl
dc.titleValidation of some extrapolation methods with toxicity data derived from multiple species experiments on organic compounds and metals in aquatic ecosystemsen
dc.title.alternativeValidatie van enkele extrapolatie methoden met toxiciteitsgegevens over organische stoffen en metalen in het aquatische milieu afkomstig uit multipele species experimentennl
dc.typeReport
dc.date.updated2012-12-12T21:36:45Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractFor effects assessment several extrapolation methods can be used to derive the concentration of toxic chemicals above which adverse effects on terrestrial or aquatic ecosystems may occur. These methods are based on single species toxicity data. At present, however, it is uncertain whether the values calculated with these extrapolation methods really represent accurate estimations of concentrations harmless to ecosystems. Therefore a validation of extrapolation methods was carried out by comparing No Observed Effect Concentrations derived from multiple species (semi-) field experiments with extrapolated values. In this study validation was restricted to the methods of Aldenberg & Slob (1991) and Wagner & Lokke (1991) and a modification of the method of the United States Environmental Protection Agency (OECD, 1991). Multiple species experiments for organic compounds and metals in aquatic ecosystems were studied. For only 29 compounds, 19 organic compounds and 10 metals, one or more multiple species NOECs could be derived. For 11 of these compounds, an insufficient number of single species toxicity data was available to apply the methods of Aldenberg & Slob and Wagner & Lokke. With reservations, due to the paucity of data, it is concluded that single species toxicity data can be used to derive "safe" values for the aquatic ecosystem. Furthermore, extrapolation methods seem to be a good basis for determining these values. Based on the results of this study the best correlation between MS NOECs and extrapolated values can be obtained with the methods of Aldenberg & Slob and Wagner & Lokke, both with a 95& protection level and a 50% confidence level.


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