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dc.contributor.authorVermeire TG
dc.contributor.authorvan Apeldoorn ME
dc.contributor.authorde Fouw JC
dc.contributor.authorJanssen PJCM
dc.date.accessioned2014-01-17T13:26:12
dc.date.issued1991-02-28
dc.identifier725201005
dc.description.abstractThis report is a description of a search of the toxicological literature and the derivation of toxicological guideline values and daily intakes for men at the Toxicology Advisory Centre of RIVM. It intends to provide a toxicological basis to proposed so-called C-values of the "Leidraad Bodemsanering" (Soil Sanitation Guide) of the Ministery of Housing, Physical Planning, and Environment. As far as possible, maximum tolerable risk levels for the total intake of genotoxic carcinogens and toxicologically tolerable daily intakes for threshold compounds have been determined for 55 chemicals or groups of chemically related compounds. In addition, a toxicologically tolerable concentration in air has been derived for 22 substances or groups of substances. A central issue in this report is the choice of the toxicological criterion for the regulatory concept "serious threat to human health" as associated with the C-value.<br>
dc.description.sponsorshipDGM/DWB-B
dc.formatapplication/pdf
dc.format.extent177 p
dc.format.extent5661 kb
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 725201005
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/725201005.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/725201005.pdf
dc.subject07nl
dc.subjecttoxische stoffennl
dc.subjectgrenswaardenl
dc.subjectmacnl
dc.subjectadinl
dc.subjectc-valuenl
dc.subjectc-waardenl
dc.subjecttoxic substancesen
dc.subjectlimitsen
dc.subjectmacen
dc.subjectadien
dc.titleVoorstel voor de humaan-toxicologische onderbouwing van C-(toetsings)waardennl
dc.title.alternativeProposal for the toxicological basis for the determination of C-valuesen
dc.typeReport
dc.date.updated2014-01-17T12:28:29Z
html.description.abstractThis report is a description of a search of the toxicological literature and the derivation of toxicological guideline values and daily intakes for men at the Toxicology Advisory Centre of RIVM. It intends to provide a toxicological basis to proposed so-called C-values of the &quot;Leidraad Bodemsanering&quot; (Soil Sanitation Guide) of the Ministery of Housing, Physical Planning, and Environment. As far as possible, maximum tolerable risk levels for the total intake of genotoxic carcinogens and toxicologically tolerable daily intakes for threshold compounds have been determined for 55 chemicals or groups of chemically related compounds. In addition, a toxicologically tolerable concentration in air has been derived for 22 substances or groups of substances. A central issue in this report is the choice of the toxicological criterion for the regulatory concept &quot;serious threat to human health&quot; as associated with the C-value.&lt;br&gt;


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