Show simple item record

dc.contributor.authorLeenhouts HP
dc.contributor.authorChadwick KH
dc.contributor.authorPruppers MJM
dc.contributor.authorWijngaard E
dc.contributor.authorSijsma MJ
dc.contributor.authorBouwens BT
dc.date.accessioned2017-02-20T06:56:51
dc.date.issued1990-04-30
dc.identifier248806001
dc.description.abstractThis report is the final report of a research contract of RIVM in the framework of the Radiation Protection Programme of the Commission of the European Communities. The aim of the project was to investigate the nature of the dose-effect relationship for radiobiological effects after different types of ionizing radiation and UV. The results of the contract support the idea that the linear-quadratic dose relationship for radiobiological effects does reflect a two-hit or two-event type of radiation effect. The track structure calculations of the linear term indicate that the DNA double-strand break could be the crucial lesion and that the two simultaneous events should occur close to each strand of the DNA molecule in a single track. The experimental data indicate that the quadratic term arises from the combination of two time independently induced events the role of which can be modified by repair but these data do not provide any information on the nature of the radiation induced lesions.<br>
dc.description.sponsorshipEG/DG12
dc.format.extent18 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 248806001
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/248806001.html
dc.subject16nl
dc.subjectcomparative risknl
dc.subjectradiationnl
dc.subjectuvnl
dc.subjectlow-dose risknl
dc.subjectrisk assessmentnl
dc.titleComparative risk assessment of radiation and other mutagenic agents. Low dose relative risk of different ionizing radiations and comparison with UV-radiationen
dc.title.alternativeRisicovergelijking van straling en andere mutagene stoffen. Het relatieve risico bij lage doses van verschillende soorten ioniserende straling en de vergelijking met UV-stralingnl
dc.typeReport
dc.date.updated2017-02-20T05:56:52Z
html.description.abstractThis report is the final report of a research contract of RIVM in the framework of the Radiation Protection Programme of the Commission of the European Communities. The aim of the project was to investigate the nature of the dose-effect relationship for radiobiological effects after different types of ionizing radiation and UV. The results of the contract support the idea that the linear-quadratic dose relationship for radiobiological effects does reflect a two-hit or two-event type of radiation effect. The track structure calculations of the linear term indicate that the DNA double-strand break could be the crucial lesion and that the two simultaneous events should occur close to each strand of the DNA molecule in a single track. The experimental data indicate that the quadratic term arises from the combination of two time independently induced events the role of which can be modified by repair but these data do not provide any information on the nature of the radiation induced lesions.&lt;br&gt;


This item appears in the following Collection(s)

Show simple item record