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    How can information on oral bioavailability improve human health risk assessment for lead-contaminated soils? Implementation and scientific basis

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    Authors
    Oomen AG
    Brandon EFA
    Swartjes FA
    Sips AJAM
    Series/Report no.
    RIVM rapport 711701042
    Type
    Report
    Language
    en
    
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    Title
    How can information on oral bioavailability improve human health risk assessment for lead-contaminated soils? Implementation and scientific basis
    Translated Title
    Hoe kan informatie over orale biobeschikbaarheid de humane risicobeoordeling verbeteren van bodems verontreinigd met lood? Implementatie en wetenschappelijke basis
    Publiekssamenvatting
    Door kennis over het opnameproces van stoffen in het menselijk lichaam beter te benutten, kan de risicobeoordeling van bodemverontreiniging voor de mens verbeterd worden. Inzicht in het opnameproces is verkregen door de nabootsing van het menselijk verteringsproces (in vitro digestiemodel).
    In dit rapport wordt een concreet voorstel gedaan om de kennis over de opname van lood door het menselijk lichaam in te passen in het nieuwe bodembeleid (Wet bodembescherming). Daarnaast wordt voor risicobeoordelaars en beleidsmakers inzichtelijk gemaakt in welke situaties het zinvol is om met het in vitro digestiemodel testen uit te voeren.
    Naast de toepassing in bodembeleid staat tevens de wetenschappelijke basis van het in vitro digestiemodel beschreven. De resultaten van het experimentele model zijn vergeleken met data van de mens en van varkens voor de verontreinigende stof lood om de juistheid van het model aan te tonen.
    Voor de toekomst is het van belang dat er internationale harmonisatie plaatsvindt over de toepassing in bodembeleid en de methodiek om kennis over het opnameproces te verkrijgen.

    he human body, the risk assessment of soil contaminants for humans can be improved. Insight into the uptake process is obtained by simulating the human digestion process (in vitro digestion model). In this report a concrete proposal is given for using the knowledge on the uptake of lead in the human body in procedures to assess the soil quality according to the new soil policy (Dutch Soil Protection Act). In addition, risk assessors and policy makers are advised on the situations where performing tests with the in vitro digestion model is desirable. Besides the application in soil policy, the scientific basis of the in vitro digestion model has been described. The experimental results of the experimental model have been compared to human and swine data for the contaminant lead to demonstrate the correctness of the model. In future, international harmonization on the application in soil policy and the methodology to obtain knowledge on the uptake process will become important.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    VROM-DGM-BWL
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