Onderzoek naar de mutagene werking van mogelijke intermediaren van de stofwisseling van 3-methyl-5-fenyl-pyridineamine op microorganismen
dc.contributor.author | Voogd CE | |
dc.contributor.author | Stell JJ van der | |
dc.contributor.author | Bruchem MC van | |
dc.contributor.author | Stavenuiter JFC | |
dc.date.accessioned | 2012-12-12T22:28:15Z | |
dc.date.available | 2012-12-12T22:28:15Z | |
dc.date.issued | 1990-05-31 | |
dc.identifier | 658804003 | |
dc.identifier.uri | http://hdl.handle.net/10029/261499 | |
dc.description.abstract | Abstract niet beschikbaar | |
dc.description.abstract | Six compounds were investigated on mutagenic properties in order to assess the most probable intermediary product that causes the mutagenicity of 3-methyl-5-phenyl-2-pyridineamine. Of these compounds 2-acetylamino-3-methyl-5-phenylpyridine was the least mutagenic one. the other substances, 3-methyl-2-nitro-5-phenylpyridine, 3-methyl-2- nitroso-5-phenylpyridine, 3-methyl-2-hyudroxylamino-5-phenylpyridine, 3-methyl-2-acetylhydroxylamino-5-phenylpyridine and N2-acetoxy-3-methyl- 5-phenylpyridineamine, were mutagenic. Furthermore, substantial differences in numbers of revertants were obtained with the Salmonella teststrains TA98, TA98NR and TA98/1,8 DNP6 with the exception of 3- methyl-2-nitro-hydroxylamino-5-phenylpyridine as the ultimate mutagen intermediar of 3-methyl-5-phenyl-2-pyridineamine. However, further investigations are needed to corroborate these conclusions. | |
dc.description.sponsorship | HIGB | |
dc.format.extent | 75 p | |
dc.language.iso | nl | |
dc.relation.ispartof | RIVM Rapport 658804003 | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/658804003.html | |
dc.subject | 07 | nl |
dc.subject | voeding | nl |
dc.subject | aminen | nl |
dc.subject | stofwisseling | nl |
dc.subject | mutageniteit | nl |
dc.subject | mutageniteitstesten | nl |
dc.subject | microorganismen | nl |
dc.subject | food | en |
dc.subject | amines | en |
dc.subject | metabolism | en |
dc.subject | mutagenicity testing | en |
dc.subject | microorganisms | en |
dc.title | Onderzoek naar de mutagene werking van mogelijke intermediaren van de stofwisseling van 3-methyl-5-fenyl-pyridineamine op microorganismen | nl |
dc.title.alternative | Investigation of the mutagenic activity of some possible intermediary compounds of the 3-methyl-5-phenyl-2-pyridineamine metabolism on microorganisms | en |
dc.type | Report | |
dc.date.updated | 2012-12-12T22:28:16Z | |
html.description.abstract | Abstract niet beschikbaar | |
html.description.abstract | Six compounds were investigated on mutagenic properties in order to assess the most probable intermediary product that causes the mutagenicity of 3-methyl-5-phenyl-2-pyridineamine. Of these compounds 2-acetylamino-3-methyl-5-phenylpyridine was the least mutagenic one. the other substances, 3-methyl-2-nitro-5-phenylpyridine, 3-methyl-2- nitroso-5-phenylpyridine, 3-methyl-2-hyudroxylamino-5-phenylpyridine, 3-methyl-2-acetylhydroxylamino-5-phenylpyridine and N2-acetoxy-3-methyl- 5-phenylpyridineamine, were mutagenic. Furthermore, substantial differences in numbers of revertants were obtained with the Salmonella teststrains TA98, TA98NR and TA98/1,8 DNP6 with the exception of 3- methyl-2-nitro-hydroxylamino-5-phenylpyridine as the ultimate mutagen intermediar of 3-methyl-5-phenyl-2-pyridineamine. However, further investigations are needed to corroborate these conclusions. |