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dc.contributor.authorAldenberg T
dc.contributor.authorSlob W
dc.date.accessioned2013-09-17T23:02:34
dc.date.issued1991-05-31
dc.identifier719102002
dc.description.abstractThis paper deals with the calculation of Hazardous Concentrations of toxic substances from small sets of laboratory toxicity data, e.g. NOECs. A procedure due to Van Straalen and Denneman, as adapted from Kooijman (case n=1), in which one seeks a concentration that protects 95% of the biological species, is modified to account for the uncertainty in the estimates. New constants are obtained by simulation, that allow the calculation of the one-sided 95% left confidence limit of the Hazardous concentration, from the mean and standard deviation of a sample of toxicity data. This 95% confidence limit is always lower than the 95% certainty value calculated with the Kooijman (n=1)/Van Straalen method. We also derive constants to calculate a one-sided 50% confidence value, that overpredicts as often as it underpredicts. This value may be used as a best guess of the Hazardous Concentration. It will always be higher than the 95% certainty value of the Kooijman (n=1)/Van Straalen method. However, by using the 50% value, one runs the risk of protecting substantially less than 95% of the biological species.<br>
dc.description.sponsorshipDGM/SR
dc.formatapplication/pdf
dc.format.extent24 p
dc.format.extent900 kb
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 719102002
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/719102002.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/719102002.pdf
dc.subject07nl
dc.subject91-2nl
dc.subjectecotoxicologienl
dc.subjectextrapolatienl
dc.subjectnoecnl
dc.subjecthazard assessmentnl
dc.subjectrisk analysisnl
dc.titleConfidence Limits for Hazardous Concentrations Based on Logistically Distributed NOEC Toxicity Dataen
dc.title.alternativeBetrouwbaarheidsgrenzen voor schadelijke concentratieniveau&apos;s op basis van logistisch verdeelde NOEC-toxiciteitsgegevensnl
dc.typeReport
dc.date.updated2013-09-17T21:02:37Z
html.description.abstractThis paper deals with the calculation of Hazardous Concentrations of toxic substances from small sets of laboratory toxicity data, e.g. NOECs. A procedure due to Van Straalen and Denneman, as adapted from Kooijman (case n=1), in which one seeks a concentration that protects 95% of the biological species, is modified to account for the uncertainty in the estimates. New constants are obtained by simulation, that allow the calculation of the one-sided 95% left confidence limit of the Hazardous concentration, from the mean and standard deviation of a sample of toxicity data. This 95% confidence limit is always lower than the 95% certainty value calculated with the Kooijman (n=1)/Van Straalen method. We also derive constants to calculate a one-sided 50% confidence value, that overpredicts as often as it underpredicts. This value may be used as a best guess of the Hazardous Concentration. It will always be higher than the 95% certainty value of the Kooijman (n=1)/Van Straalen method. However, by using the 50% value, one runs the risk of protecting substantially less than 95% of the biological species.&lt;br&gt;


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