Confidence Limits for Hazardous Concentrations Based on Logistically Distributed NOEC Toxicity Data
dc.contributor.author | Aldenberg T | |
dc.contributor.author | Slob W | |
dc.date.accessioned | 2013-09-17T23:02:34 | |
dc.date.issued | 1991-05-31 | |
dc.identifier | 719102002 | |
dc.description.abstract | This paper deals with the calculation of Hazardous Concentrations of toxic substances from small sets of laboratory toxicity data, e.g. NOECs. A procedure due to Van Straalen and Denneman, as adapted from Kooijman (case n=1), in which one seeks a concentration that protects 95% of the biological species, is modified to account for the uncertainty in the estimates. New constants are obtained by simulation, that allow the calculation of the one-sided 95% left confidence limit of the Hazardous concentration, from the mean and standard deviation of a sample of toxicity data. This 95% confidence limit is always lower than the 95% certainty value calculated with the Kooijman (n=1)/Van Straalen method. We also derive constants to calculate a one-sided 50% confidence value, that overpredicts as often as it underpredicts. This value may be used as a best guess of the Hazardous Concentration. It will always be higher than the 95% certainty value of the Kooijman (n=1)/Van Straalen method. However, by using the 50% value, one runs the risk of protecting substantially less than 95% of the biological species.<br> | |
dc.description.sponsorship | DGM/SR | |
dc.format | application/pdf | |
dc.format.extent | 24 p | |
dc.format.extent | 900 kb | |
dc.language.iso | en | |
dc.publisher | Rijksinstituut voor Volksgezondheid en Milieu RIVM | |
dc.relation.ispartof | RIVM Rapport 719102002 | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/719102002.html | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/719102002.pdf | |
dc.subject | 07 | nl |
dc.subject | 91-2 | nl |
dc.subject | ecotoxicologie | nl |
dc.subject | extrapolatie | nl |
dc.subject | noec | nl |
dc.subject | hazard assessment | nl |
dc.subject | risk analysis | nl |
dc.title | Confidence Limits for Hazardous Concentrations Based on Logistically Distributed NOEC Toxicity Data | en |
dc.title.alternative | Betrouwbaarheidsgrenzen voor schadelijke concentratieniveau's op basis van logistisch verdeelde NOEC-toxiciteitsgegevens | nl |
dc.type | Report | |
dc.date.updated | 2013-09-17T21:02:37Z | |
html.description.abstract | This paper deals with the calculation of Hazardous Concentrations of toxic substances from small sets of laboratory toxicity data, e.g. NOECs. A procedure due to Van Straalen and Denneman, as adapted from Kooijman (case n=1), in which one seeks a concentration that protects 95% of the biological species, is modified to account for the uncertainty in the estimates. New constants are obtained by simulation, that allow the calculation of the one-sided 95% left confidence limit of the Hazardous concentration, from the mean and standard deviation of a sample of toxicity data. This 95% confidence limit is always lower than the 95% certainty value calculated with the Kooijman (n=1)/Van Straalen method. We also derive constants to calculate a one-sided 50% confidence value, that overpredicts as often as it underpredicts. This value may be used as a best guess of the Hazardous Concentration. It will always be higher than the 95% certainty value of the Kooijman (n=1)/Van Straalen method. However, by using the 50% value, one runs the risk of protecting substantially less than 95% of the biological species.<br> |