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dc.contributor.authorde Jong APJM
dc.contributor.authorLiem AKD
dc.contributor.authorHoogerbrugge R
dc.date.accessioned2017-02-20T07:57:18
dc.date.issued1992-02-29
dc.identifier730501044
dc.description.abstractSix laboratories in four European countries (GER, GB, S, NL) have conducted an interlaboratory comparison study on the analysis of dioxins in cow's milk. The study comprised a cross comparison of standards and the analysis of the 2,3,7,8-substituded congeners of have used their own procedures and methods for fat and dioxin determination in biological samples, all using non-polar gas chromatography and medium to high resolution mass spectrometry (RP = 3.000-10.000). Quantification was preformed by the use of a common quantification standard mixture of the native PCDD/Fs (4 labs) or the own quantification standards (2 labs). Within- laboratory reproducibilities for the determination of the major toxic isomers and the total TCDD toxicity equivalence (TE) level were between 2 and 16% (relative standard deviation (RSD)) with a mean of 8%. The interlaboratory variability in TE values was less than 12% (RSD) for TE values between 2.8 and 10.4 pg/g milk fat. The reliability of participant standards was difficult to assess and probably less good than expected. Deviations between found and expected concentrations in these standards were on average within 25% and for some congeners to 50% in some laboratories, when quantified against a common standard.<br>
dc.description.sponsorshipHIMH
dc.formatapplication/pdf
dc.format.extent17 p
dc.format.extent742 kb
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 730501044
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/730501044.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/730501044.pdf
dc.subject11nl
dc.subject92-1nl
dc.subjecttoxiciteitsgehaltenl
dc.subjectbiological calibration pcddnl
dc.subjectpcdfnl
dc.titleInterlaboratory comparison study on dioxins in cow&apos;s milken
dc.title.alternativeInterlaboratorium vergelijkingsonderzoek naar dioxines in in koe melknl
dc.typeReport
dc.date.updated2017-02-20T06:57:18Z
html.description.abstractSix laboratories in four European countries (GER, GB, S, NL) have conducted an interlaboratory comparison study on the analysis of dioxins in cow&apos;s milk. The study comprised a cross comparison of standards and the analysis of the 2,3,7,8-substituded congeners of have used their own procedures and methods for fat and dioxin determination in biological samples, all using non-polar gas chromatography and medium to high resolution mass spectrometry (RP = 3.000-10.000). Quantification was preformed by the use of a common quantification standard mixture of the native PCDD/Fs (4 labs) or the own quantification standards (2 labs). Within- laboratory reproducibilities for the determination of the major toxic isomers and the total TCDD toxicity equivalence (TE) level were between 2 and 16% (relative standard deviation (RSD)) with a mean of 8%. The interlaboratory variability in TE values was less than 12% (RSD) for TE values between 2.8 and 10.4 pg/g milk fat. The reliability of participant standards was difficult to assess and probably less good than expected. Deviations between found and expected concentrations in these standards were on average within 25% and for some congeners to 50% in some laboratories, when quantified against a common standard.&lt;br&gt;


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