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dc.contributor.authorJacquemijns M
dc.contributor.authorZomer G
dc.date.accessioned2012-12-13T09:28:15Z
dc.date.available2012-12-13T09:28:15Z
dc.date.issued1990-12-31
dc.identifier638903003
dc.identifier.urihttp://hdl.handle.net/10029/262473
dc.description.abstractD7]Bentazone was sysnthesized from methyl antranilate and [D7 isopropylsulfamoyl chloride. [D7]Isopropylsulfamoyl chloride was prepared by treatment of [D7]isopropyl amine with chlorosulfonic acid and phosphorous pentachloride. The overall yield from D7]isopropyl amine was 7% and the isotopic purity was estimated to be >95%. Direct deuteration of bentazone with deuterium oxide did not occur and the temperature used for this deutarition (100 degr. C) caused a rearrangement. Attempts to prepare bentazone by substitution of isopropyl iodide or isopropyl toxylate to the potassium-sodium- or cesiumsalt of 1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide failed.<br>
dc.description.sponsorshipHIMH
dc.format.extent31 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 638903003
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/638903003.html
dc.subject20nl
dc.subject91-4nl
dc.subjectbentazon [d7nl
dc.subjectsynthesenl
dc.titleSynthesis of 3-[D7]isopropylbenzo-2-thia-1,3-diazinon-(4)-2,2- dioxide ([D7]-bentazone)en
dc.title.alternativeSynthese van 3-[D7]isopropylbenzo-2-thia-1,3-diazinon-(4)-2,2- dioxide ([D7]-bentazone)nl
dc.typeReport
dc.date.updated2012-12-13T09:28:16Z
html.description.abstractD7]Bentazone was sysnthesized from methyl antranilate and [D7 isopropylsulfamoyl chloride. [D7]Isopropylsulfamoyl chloride was prepared by treatment of [D7]isopropyl amine with chlorosulfonic acid and phosphorous pentachloride. The overall yield from D7]isopropyl amine was 7% and the isotopic purity was estimated to be &gt;95%. Direct deuteration of bentazone with deuterium oxide did not occur and the temperature used for this deutarition (100 degr. C) caused a rearrangement. Attempts to prepare bentazone by substitution of isopropyl iodide or isopropyl toxylate to the potassium-sodium- or cesiumsalt of 1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide failed.&lt;br&gt;


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