RIVM employees can, apart from their task in publishing RIVM reports, write their findings to (international) scientific journals. Below you can find various articles that have appeared in such journals, that are written by at least one (former) RIVM employee.

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  • The association of vitamin D with survival in colorectal cancer patients depends on antioxidant capacity.

    Boakye, Daniel; Jansen, Lina; Schöttker, Ben; Jansen, Eugene H J M; Halama, Niels; Maalmi, Haifa; Gào, Xin; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann (2021-03-19)
  • Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial model.

    Bessa, Maria João; Brandão, Fátima; Fokkens, Paul; Cassee, Flemming R; Salmatonidis, Apostolos; Viana, Mar; Vulpoi, Adriana; Simon, Simion; Monfort, Eliseo; Teixeira, João Paulo; et al. (2021-03-18)
    The advanced ceramic technology has been pointed out as a potentially relevant case of occupational exposure to nanoparticles (NP). Not only when nanoscale powders are being used for production, but also in the high-temperature processing of ceramic materials there is also a high potential for NP release into the workplace environment. In vitro toxicity of engineered NP (ENP) [antimony tin oxide (Sb2O3•SnO2; ATO); zirconium oxide (ZrO2)], as well as process-generated NP (PGNP), and fine particles (PGFP), was assessed in MucilAir™ cultures at air-liquid interface (ALI). Cultures were exposed during three consecutive days to varying doses of the aerosolized NP. General cytotoxicity [lactate dehydrogenase (LDH) release, WST-1 metabolization], (oxidative) DNA damage, and the levels of pro-inflammatory mediators (IL-8 and MCP-1) were assessed. Data revealed that ENP (5.56 µg ATO/cm2 and 10.98 µg ZrO2/cm2) only caused mild cytotoxicity at early timepoints (24 h), whereas cells seemed to recover quickly since no significant changes in cytotoxicity were observed at late timepoints (72 h). No meaningful effects of the ENP were observed regarding DNA damage and cytokine levels. PGFP affected cell viability at dose levels as low as ∼9 µg/cm2, which was not seen for PGNP. However, exposure to PGNP (∼4.5 µg/cm2) caused an increase in oxidative DNA damage. These results indicated that PGFP and PGNP exhibit higher toxicity potential than ENP in mass per area unit. However, the presence of a mucociliary apparatus, as it occurs in vivo as a defense mechanism, seems to considerably attenuate the observed toxic effects. Our findings highlight the potential hazard associated with exposure to incidental NP in industrial settings.
  • Development of a Measles and Rubella Multiplex Bead Serological Assay for Assessing Population Immunity.

    Coughlin, Melissa M; Matson, Zachary; Sowers, Sun B; Priest, Jeffrey W; Smits, Gaby P; van der Klis, Fiona R M; Mitchell, Alexandria; Hickman, Carole J; Scobie, Heather M; Goodson, James L; et al. (2021-03-17)
    Serosurveys are important tools for estimating population immunity and providing immunization activity guidance. The measles and rubella multiplex bead assay (MBA) offers multiple advantages over standard serological assays and was validated by comparison with the enzyme-linked immunosorbent assay (ELISA) and the measles plaque reduction neutralization (PRN) assay. Results from a laboratory-produced purified measles whole virus antigen MBA (MeV WVAL) correlated better with ELISA and PRN than results from the baculovirus-expressed measles nucleoprotein (N) MBA. Therefore, a commercially produced whole virus antigen (MeV WVAC) was evaluated. Serum IgG antibody concentrations correlated significantly with a strong linear relationship between the MeV WVAC and MeV WVAL MBAs (R=0.962, R2=0.926). IgG concentrations from the MeV WVAC MBA showed strong correlation with PRN titers (R=0.846) with a linear relationship comparable to values obtained with the MeV WVAL MBA and PRN assay (R2=0.716 and R2=0.768, respectively). Receiver-operating characteristic (ROC) curve analysis of the MeV WVAC using PRN titer as the comparator resulted in a seroprotection cutoff of 153 mIU/ml, similar to the established correlate of protection of 120 mIU/ml, with a sensitivity of 98% and a specificity of 84%. IgG concentrations correlated strongly between the rubella WVA MBA and ELISA (R=0.959 and R2=0.919). ROC analysis of the rubella MBA using ELISA as the comparator yielded a cutoff of 9.36 IU/ml, similar to the accepted cutoff of 10 IU/ml for seroprotection, with a sensitivity of 99% and a specificity of 100%. These results support use of the MBA for multi-antigen serosurveys assessing measles and rubella population immunity.
  • Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

    Kananen, L; Enroth, L; Raitanen, J; Jylhävä, J; Bürkle, A; Moreno-Villanueva, M; Bernhardt, J; Toussaint, O; Grubeck-Loebenstein, B; Malavolta, M; et al. (2021-03-17)
  • Real-World Treatment Costs and Care Utilization in Patients with Major Depressive Disorder With and Without Psychiatric Comorbidities in Specialist Mental Healthcare.

    Kan, Kaying; Lokkerbol, Joran; Jörg, Frederike; Visser, Ellen; Schoevers, Robert A; Feenstra, Talitha L (2021-03-16)
  • Method for extraction of nanoscale plastic debris from soil.

    Abdolahpur Monikh, Fazel; Doornhein, Nikki; Romeijn, Stefan; Vijver, Martina G; Peijnenburg, Willie J G M (2021-03-15)
  • Protection of drinking water resources from agricultural pressures: Effectiveness of EU regulations in the context of local realities.

    Wuijts, Susanne; Claessens, Jacqueline; Farrow, Luke; Doody, Donnacha G; Klages, Susanne; Christophoridis, Chris; Cvejić, Rozalija; Glavan, Matjaž; Nesheim, Ingrid; Platjouw, Froukje; et al. (2021-03-15)
  • Contribution of pristine and reduced microbial extracellular polymeric substances of different sources to Cu(II) reduction.

    Xu, Hang; He, Erkai; Peijnenburg, Willie J G M; Song, Lan; Zhao, Ling; Xu, Xiaoyun; Cao, Xinde; Qiu, Hao (2021-03-12)
  • Cost-effectiveness of a stepwise cardiometabolic disease prevention program: results of a randomized controlled trial in primary care.

    Stol, Daphne M; Over, Eelco A B; Badenbroek, Ilse F; Hollander, Monika; Nielen, Mark M J; Kraaijenhagen, Roderik A; Schellevis, François G; de Wit, Niek J; de Wit, G Ardine (2021-03-11)
  • The mediating role of lifestyle in the relationship between shift work, obesity and diabetes.

    Hulsegge, Gerben; Proper, Karin I; Loef, Bette; Paagman, Heleen; Anema, Johannes R; van Mechelen, Willem (2021-03-11)
    In this cross-sectional study, 3188 shift workers and 6395 non-shift workers participated between 2013 and 2018 in periodical occupational health checks. Weight and height were objectively measured to calculate obesity (BMI ≥ 30 kg/m2). Diabetes status, physical activity, diet, smoking, and sleep quality were assessed using standardized questionnaires. Structural equation models adjusted for relevant confounders were used to analyze the mediating role of lifestyle in the relationships between shift work, and obesity and diabetes.
  • Inactivation of Trichinella muscle larvae at different time-temperature heating profiles simulating home-cooking.

    Franssen, Frits; Deng, Huifang; Swart, Arno; Marinović, Axel Bonačić; Liu, Xiaolei; Liu, Mingyuan; Van Der Giessen, Joke (2021-03-11)
  • Human reading computer automated reading of chest X-rays in a tuberculosis screening programme in Romania.

    de Vries, Gerard; Gainaru, Dan; Keizer, Sytze; Mahler, Beatrice; Radulescu, Ileana; Zamfirescu, Marina; Abubakar, Ibrahim (2021-03-10)
  • National point prevalence study on carriage of multidrug-resistant microorganisms in Dutch long-term care facilities in 2018.

    van Kleef, Esther; Wielders, Cornelia C H; Schouls, Leo M; Feenstra, Sabiena G; Hertogh, Cees M P M; Bonten, Marc J M; van Weert, Yolanda; Tostmann, Alma; van der Lubben, Mariken; de Greeff, Sabine C (2021-03-10)
  • Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020.

    Ventura, Célia; Gomes, Bruno Costa; Oberemm, Axel; Louro, Henriqueta; Huuskonen, Pasi; Mustieles, Vicente; Fernández, Mariana F; Ndaw, Sophie; Mengelers, Marcel; Luijten, Mirjam; et al. (2021-03-10)
  • The extent of carbapenemase-encoding genes in public genome sequences.

    Janse, Ingmar; Beeloo, Rick; Swart, Arno; Visser, Michael; Schouls, Leo; van Duijkeren, Engeline; van Passel, Mark W J (2021-03-09)
    Genome sequences provide information on the genetic elements present in an organism, and currently there are databases containing hundreds of thousands of bacterial genome sequences. These repositories allow for mining patterns concerning antibiotic resistance gene occurrence in both pathogenic and non-pathogenic bacteria in e.g. natural or animal environments, and link these to relevant metadata such as bacterial host species, country and year of isolation, and co-occurrence with other resistance genes. In addition, the advances in the prediction of mobile genetic elements, and discerning chromosomal from plasmid DNA, broadens our view on the mechanism mediating dissemination. In this study we utilize the vast amount of data in the public database PATRIC to investigate the dissemination of carbapenemase-encoding genes (CEGs), the emergence and spread of which is considered a grave public health concern. Based on publicly available genome sequences from PATRIC and manually curated CEG sequences from the beta lactam database, we found 7,964 bacterial genomes, belonging to at least 70 distinct species, that carry in total 9,892 CEGs, amongst which blaNDM, blaOXA, blaVIM, blaIMP and blaKPC. We were able to distinguish between chromosomally located resistance genes (4,137; 42%) and plasmid-located resistance genes (5,753; 58%). We found that a large proportion of the identified CEGs were identical, i.e. displayed 100% nucleotide similarity in multiple bacterial species (8,361 out of 9,892 genes; 85%). For example, the New Delhi metallo-beta-lactamase NDM-1 was found in 42 distinct bacterial species, and present in seven different environments. Our data show the extent of carbapenem-resistance far beyond the canonical species Acetinobacter baumannii, Klebsiella pneumoniae or Pseudomonas aeruginosa. These types of data complement previous systematic reviews, in which carbapenem-resistant Enterobacteriaceae were found in wildlife, livestock and companion animals. Considering the widespread distribution of CEGs, we see a need for comprehensive surveillance and transmission studies covering more host species and environments, akin to previous extensive surveys that focused on extended spectrum beta-lactamases. This may help to fully appreciate the spread of CEGs and improve the understanding of mechanisms underlying transmission, which could lead to interventions minimizing transmission to humans.
  • Potency of olorofim (F901318) compared to contemporary antifungal agents against clinical isolates, and review of azole resistance phenotype and genotype epidemiology in China.

    Su, Huilin; Zhu, Min; Tsui, Clement Kin-Ming; van der Lee, Henrich; Tehupeiory-Kooreman, Marlou; Zoll, Jan; Engel, Tobias; Li, Li; Zhu, Junhao; Lu, Zihan; et al. (2021-03-08)
    Triazole resistance in A. fumigatus is an increasing worldwide problem that causes major challenges in the management of aspergillosis. New antifungal drugs are needed with novel targets, that are effective in triazole-resistant infection. In this study, we retrospectively evaluated potency of the novel drug olorofim compared to contemporary antifungal agents against 111 clinical A. fumigatus isolates collected from Huashan Hospital, Shanghai, China, using EUCAST methodology, and reviewed the literature on triazole resistant A. fumigatus published between 1966 and 2020 in China. Olorofim was active in vitro against all tested A. fumigatus isolates with MIC90 of 0.031mg/L (range 0.008-0.062 mg/L). For 4 triazole-resistant A. fumigatus (TRAF) isolates, the olorofim MIC ranged between 0.016-0.062mg/L. The reported rates of TRAF in China is 2.5% - 5.56% for clinical isolates, and 0-1.4% for environmental isolates.TR34/L98H/S297T/F495I is the predominant resistance mechanism, followed by TR34/L98H. Non TR-mediated TRAF isolates, mostly harboring a cyp51A single point mutation, showed greater genetic diversity than TR-mediated resistant isolates. Resistance due toTR34/L98H and TR34/L98H/S297T/F495I mutations among TRAF isolates might have evolved from separate local isolates in China. Continuous isolation of TRAF in China underscores the need for systematic resistance surveillance as well as the need for novel drug targets such as olorofim.
  • Does surrounding greenness moderate the relationship between apparent temperature and physical activity? Findings from the PHENOTYPE project.

    Ho, Janice Y; Zijlema, Wilma L; Triguero-Mas, Margarita; Donaire-Gonzalez, David; Valentín, Antònia; Ballester, Joan; Chan, Emily Y Y; Goggins, William B; Mo, Phoenix K H; Kruize, Hanneke; et al. (2021-03-08)
  • Measles outbreak in complex emergency: estimating vaccine effectiveness and evaluation of the vaccination campaign in Borno State, Nigeria, 2019.

    Jean Baptiste, Anne Eudes; Wagai, John; Luce, Richard; Masresha, Balcha; Klinkenberg, Don; Veldhuijzen, Irene; Oteri, Joseph; Dieng, Boubacar; Ikeonu, Obianuju Caroline; Meleh, Sule; et al. (2021-03-04)
  • Cost of childhood acute otitis media in primary care in the Netherlands: economic analysis alongside a cluster randomised controlled trial.

    van Uum, Rick T; Venekamp, Roderick P; Pasmans, Clémence T B; de Wit, G Ardine; Sjoukes, Alies; van der Pol, Alma C; Damoiseaux, Roger A M J; Schilder, Anne G M (2021-03-04)
  • Both non-smoking youth and smoking adults like sweet and minty e-liquid flavors more than tobacco flavor.

    Krüsemann, Erna J Z; van Tiel, Loes; Pennings, Jeroen L A; Vaessen, Wim; de Graaf, Kees; Talhout, Reinskje; Boesveldt, Sanne (2021-03-04)

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