• Face-touching behavior as a possible correlate of mask-wearing: A video observational study of public place incidents during the COVID-19 pandemic.

      Liebst, Lasse S; Ejbye-Ernst, Peter; de Bruin, Marijn; Thomas, Josephine; Lindegaard, Marie R (2021-04-05)
    • Facilitating the decision-making process after a nuclear accident - case studies in the Netherlands and Slovakia.

      van Asselt, Esther D; Twenhöfel, Chris J W; Duranova, Tatiana; Smetsers, Ronald C G M; Bohunova, Jarmila; Müller, Tim (2020-11-23)
    • Factors affecting antibody responses to immunizations in infants born to women immunized against pertussis in pregnancy and unimmunized women: Individual-Participant Data Meta-analysis.

      Abu-Raya, Bahaa; Maertens, Kirsten; Munoz, Flor M; Zimmermann, Petra; Curtis, Nigel; Halperin, Scott A; Rots, Nynke; Barug, Daan; Holder, Beth; Rice, Thomas F; et al. (2021-09-29)
    • Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies.

      Anusruti, Ankita; Xuan, Yang; Gào, Xīn; Jansen, Eugène H J M; Laetsch, Dana Clarissa; Brenner, Hermann; Schöttker, Ben (2020-01-01)
      In the meta-analysis of the cross-sectional analysis, female sex, low education, obesity, smoking, high total cholesterol, hemoglobin A1c ≥7%, no diabetes medication, a history of myocardial infarction, heart failure, a history of cancer and C reactive protein levels (CRP) >3 mg/L were statistically significantly associated with increased D-ROM levels in patients with T2DM. The meta-analysis of the longitudinal analysis revealed that old age, female sex, obesity, smoking, physical inactivity, high alcohol consumption, ≥5 years since diabetes diagnosis and CRP levels between 3 mg/L and 10 mg/L were statistically significantly associated with D-ROM levels measured 3-4 years later.
    • Factsheet Elektromagnetische velden en medische hulpmiddelen

      Stam, R (Rijksinstituut voor Volksgezondheid en Milieu, 2019-12-01)
    • Faecal carriage, risk factors, acquisition and persistence of ESBL-producing Enterobacteriaceae in dogs and cats and co-carriage with humans belonging to the same household.

      van den Bunt, G; Fluit, A C; Spaninks, M P; Timmerman, A J; Geurts, Y; Kant, A; Scharringa, J; Mevius, D; Wagenaar, J A; Bonten, M J M; et al. (2019-11-11)
    • Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract - a systematic review.

      Bilsen, Manu P; Lambregts, Merel M C; van Prehn, Joffrey; Kuijper, Ed J (2021-10-11)
    • Faeces as a novel material to estimate lyssavirus prevalence in bat populations.

      Begeman, Lineke; Kooi, Engbert A; van Weezep, Erik; van de Bildt, Marco W G; Reusken, Chantal B E M; Lina, Peter H C; Koopmans, Marion P G; van den Brand, Judith M A; Kuiken, Thijs (2020-03-01)
    • Failure to detect MERS-CoV RNA in urine of naturally infected dromedary camels.

      Farag, Elmoubasher A; Haagmans, Bart L; Al-Romaihi, Hamad; Mohran, Khaled; Haroun, Mohamed; El-Sayed, Ahmed M; Koopmans, Marion; AlHajri, Mohammed; Reusken, Chantal B E M (2019-01-01)
    • FAIRification of nanosafety data to improve applicability of (Q)SAR approaches: A case study on Comet assay genotoxicity data.

      Bossa, Cecilia; Andreoli, Cristina; Bakker, Martine; Barone, Flavia; De Angelis, Isabella; Jeliazkova, Nina; Nymark, Penny; Battistelli, Chiara Laura
      (Quantitative) structure-activity relationship ([Q]SAR) methodologies are widely applied to predict the (eco)toxicological effects of chemicals, and their use is envisaged in different regulatory frameworks for filling data gaps of untested substances. However, their application to the risk assessment of nanomaterials is still limited, also due to the scarcity of large and curated experimental datasets. Despite a great amount of nanosafety data having been produced over the last decade in international collaborative initiatives, their interpretation, integration and reuse has been hampered by several obstacles, such as poorly described (meta)data, non-standard terminology, lack of harmonized reporting formats and criteria. Recently, the FAIR (Findable, Accessible, Interoperable, and Reusable) principles have been established to guide the scientific community in good data management and stewardship. The EU H2020 Gov4Nano project, together with other international projects and initiatives, is addressing the challenge of improving nanosafety data FAIRness, for maximizing their availability, understanding, exchange and ultimately their reuse. These efforts are largely supported by the creation of a common Nanosafety Data Interface, which connects a row of project-specific databases applying the eNanoMapper data model. A wide variety of experimental data relating to characterization and effects of nanomaterials are stored in the database; however, the methods, protocols and parameters driving their generation are not fully mature. This article reports the progress of an ongoing case study in the Gov4nano project on the reuse of in vitro Comet genotoxicity data, focusing on the issues and challenges encountered in their FAIRification through the eNanoMapper data model. The case study is part of an iterative process in which the FAIRification of data supports the understanding of the phenomena underlying their generation and, ultimately, improves their reusability.
    • Fairmode: Update on current harmonisation initiatives

      Thunis P; Janssen S; Wesseling J; Tarrason L; Guevara M; Belis C; Pirovano (2018-06-06)
    • False hyperlactatemia in ethylene glycol poisoning.

      Fijen, Jan-Willem; Kemperman, Hans; Ververs, F F Tessa; Meulenbelt, Jan (2006-04-01)
    • Familiarity of general practitioners with Q fever decreases hospitalisation risk.

      Fanoy, E; Dijkstra, F; van der Hoek, W; Schneeberger, P; van de Kassteele, J; Rietveld, A (2018-05)
      Between 2007 and 2010, the Netherlands experienced large outbreaks of Q fever with over 4000 cases. There were unexplained geographical differences in hospitalisation rates of notified patients. We examined the extent of this geographic variation in Q fever hospitalisation and its potential association with general practitioner (GP) experience with Q fever.
    • Farm dust resistomes and bacterial microbiomes in European poultry and pig farms.

      Luiken, Roosmarijn E C; Van Gompel, Liese; Bossers, Alex; Munk, Patrick; Joosten, Philip; Hansen, Rasmus Borup; Knudsen, Berith E; García-Cobos, Silvia; Dewulf, Jeroen; Aarestrup, Frank M; et al. (2020-07-29)
    • Fast approximate computation of cervical cancer screening outcomes by a deterministic multiple-type HPV progression model.

      Vänskä, Simopekka; Bogaards, Johannes A; Auranen, Kari; Lehtinen, Matti; Berkhof, Johannes (2019-01-16)
      Cervical cancer arises differentially from infections with up to 14 high-risk human papillomavirus (HPV) types, making model-based evaluations of cervical cancer screening strategies computationally heavy and structurally complex. Thus, with the high number of HPV types, microsimulation is typically used to investigate cervical cancer screening strategies. We developed a feasible deterministic model that integrates varying natural history of cervical cancer by the different high-risk HPV types with compressed mixture representations of the screened population, allowing for fast computation of screening interventions. To evaluate the method, we built a corresponding microsimulation model. The outcomes of the deterministic model were stable over different levels of compression and agreed with the microsimulation model for all disease states, screening outcomes, and levels of cancer incidence. The compression reduced the computation time more than 1000 fold when compared to microsimulation in a cohort of 1 million women. The compressed mixture representations enable the assessment of uncertainties surrounding the natural history of cervical cancer and screening decisions in a computationally undemanding way.
    • Fasting leptin and appetite responses induced by a 4-day 65%-energy-restricted diet.

      Mars, M; Graaf, C de; Groot, C P G M de; Rossum, Caroline T M van; Kok, F J (2006-01-01)
      OBJECTIVE: Animal studies show that the leptin decline after acute severe caloric restriction is a peripheral signal to increase food intake. However, most human studies have failed to observe such a relationship. We studied the acute effects of severe caloric restriction on the association between serum leptin concentrations and subjective appetite. SUBJECTS: A total of 44 healthy adult men (aged: 43 +/- 5 years; BMI: 27.3 +/- 3.2 kg/m(2)). MEASUREMENTS: Fasting serum leptin concentrations and self-perceived appetite levels were measured during a 4-day diet containing 36% of the estimated energy requirements. Appetite levels were assessed with a 10-point Likert scale, reflecting hunger, fullness, desire to eat, prospective consumption and total appetite. RESULTS: After the 4-day energy deficit, fasting leptin concentrations decreased by 39.4% (95% CI: -43.6; -34.9%). This decline was associated with an increase in fasting hunger (r = -0.42; P < 0.01), desire to eat (r = -0.39; P < 0.05) and total appetite (r = -0.38; P < 0.05). Furthermore, the association between fasting leptin concentrations and fasting appetite levels became stronger during the energy restriction period (for total appetite: day 0 r = -0.15, P = 0.32; day 2 r = -0.31, P =< 0.05; day 4 r = -0.41, P < 0.01). CONCLUSIONS: The acute proportional reduction in fasting leptin after 4-day energy restriction is associated with an increase in self-perceived appetite. Additionally, the inverse association between proportional fasting leptin concentrations and self-perceived appetite response becomes stronger as energy restriction is prolonged. These findings suggest that leptin has an instrumental role in restoring energy balance in humans through the expression of appetite.
    • A fatal case of metastatic squamous cell carcinoma in a patient with myositis ossificans traumatica.

      Vlasveld, I N; Scheper, H; Stalenhoef, J; Baas, J M; van Dissel, J (2017-07)
      Myositis ossificans traumatica is a rare disease associated with chronic wounds and fistulae. Chronic ulcers, fistulae and wounds can transform into squamous cell carcinoma, the so-called Marjolin's ulcer. We describe a rapid, progressive and fulminant course of a metastatic squamous cell carcinoma arising from a chronic wound in a patient with myositis ossificans traumatica.
    • Fatal diphtheria myocarditis in a 3-year-old girl-related to late availability and administration of antitoxin?

      Van Damme, Karlijn; Peeters, Natasja; Jorens, Philippe G; Boiy, Tine; Deplancke, Marjan; Audiens, Hilde; Wojciechowski, Marek; De Dooy, Jozef; Te Wierik, Margreet; Vlieghe, Erika (2017-09-29)
      Sporadic cases of diphtheria are very rare throughout Europe. A 3-year-old incompletely vaccinated girl was admitted with pharyngotonsillitis caused by diphtheria. On day 9 of her illness, renal and cardiac failure with a third-degree AV-block occurred. Unfortunately, she died within 36 h of admission to intensive care, despite pacemaker placement, the administration of antibiotics and diphtheria antitoxin. The delayed antitoxin administration 7 days after admission to hospital was related to a lack of availability and knowledge of its availability in Europe and this is likely to have contributed to the unfavourable outcome.
    • Fatalities, Cerebral Hemorrhage, and Severe Cardiovascular Toxicity After Exposure to the New Psychoactive Substance 4-Fluoroamphetamine: A Prospective Cohort Study.

      Hondebrink, Laura; Nugteren-van Lonkhuyzen, Johanna J; Rietjens, Saskia J; Brunt, Tibor M; Venhuis, Bastiaan; Soerdjbalie-Maikoe, Vidija; Smink, Beitske E; van Riel, Antoinette J H P; de Vries, Irma (2017-09-29)
      We study adverse health effects after use of the new psychoactive substance 4-fluoroamphetamine.