• Latent classes of sexual risk and corresponding STI and HIV positivity among MSM attending centres for sexual health in the Netherlands.

      Slurink, Isabel A L; van Benthem, Birgit H B; van Rooijen, Martijn S; Achterbergh, Roel C A; van Aar, Fleur (2019-06-20)
    • Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling.

      Korthals Altes, Hester; Kloet, Serieke; Cobelens, Frank; Bootsma, Martin (2018)
      While tuberculosis (TB) represents a significant disease burden worldwide, low-incidence countries strive to reach the WHO target of pre-elimination by 2035. Screening for TB in immigrants is an important component of the strategy to reduce the TB burden in low-incidence settings. An important option is the screening and preventive treatment of latent TB infection (LTBI). Whether this policy is worthwhile depends on the extent of transmission within the country, and introduction of new cases through import. Mathematical transmission models of TB have been used to identify key parameters in the epidemiology of TB and estimate transmission rates. An important application has also been to investigate the consequences of policy scenarios. Here, we formulate a mathematical model for TB transmission within the Netherlands to estimate the size of the pool of latent infections, and to determine the share of importation-either through immigration or travel- versus transmission within the Netherlands. We take into account importation of infections due to immigration, and travel to the country of origin, focusing on the three ethnicities most represented among foreign-born TB cases (after exclusion of those overrepresented among asylum seekers): Moroccans, Turkish and Indonesians. We fit a system of ordinary differential equations to the data from the Netherlands Tuberculosis Registry on (extra-)pulmonary TB cases from 1995-2013. We estimate that about 27% of Moroccans, 25% of Indonesians, and 16% of Turkish, are latently infected. Furthermore, we find that for all three foreign-born communities, immigration is the most important source of LTBI, but the extent of within-country transmission is much lower (about half) for the Turkish and Indonesian communities than for the Moroccan. This would imply that contact investigation would have a greater yield in the latter community than in the former. Travel remains a minor factor contributing LTBI, suggesting that targeting returning travelers might be less effective at preventing LTBI than immigrants upon entry in the country.
    • Latent tuberculosis screening and treatment among asylum seekers: a mixed methods study.

      Spruijt, Ineke; Tesfay Haile, Dawit; Suurmond, Jeanine; van den Hof, Susan; Koenders, Marga; Kouw, Peter; van Noort, Natascha; Toumanian, Sophie; Cobelens, Frank; Goosen, Simone; et al. (2019-09-19)
    • Latent tuberculosis screening and treatment among asylum seekers: a mixed-methods study.

      Spruijt, Ineke; Erkens, Connie; van den Hof, Susan; Cobelens, Frank (2020-04-01)
    • De LCI in 2016: van A(viaire influenza) tot Z(ika).

      Haverkate M; Broek I van den; Oomen T; SwaanC (2017-10)
    • De LCI in 2017

      Meiberg, AE; Haverkate, MR; Veenstra, T; Swaan, CM (2018-10-10)
    • LCIA framework and cross-cutting issues guidance within the UNEP-SETAC Life Cycle Initiative

      Verones, Francesca; Bare, Jane; Bulle, Cécile; Frischknecht, Rolf; Hauschild, Michael; Hellweg, Stefanie; Henderson, Andrew; Jolliet, Olivier; Laurent, Alexis; Liao, Xun; et al. (2017-09)
    • Learning from games: stakeholders' experiences involved in local health policy.

      Spitters, H P E M; van de Goor, L A M; Lau, C Juel; Sandu, P; Eklund Karlsson, L; Jansen, J; van Oers, J A M (2018-03-01)
      Since public health problems are complex and the related policies need to address a wide range of sectors, cross-sectoral collaboration is beneficial. One intervention focusing on stimulating collaboration is a 'policy game'. The focus on specific problems facilitates relationships between the stakeholders and stimulates cross-sectoral policymaking. The present study explores stakeholders' learning experiences with respect to the collaboration process in public health policymaking. This was achieved via their game participation, carried out in real-life stakeholder networks in the Netherlands, Denmark and Romania. The policy game (In2Action) was developed and implemented as a 1-day role-play. The data consisted of: (i) observations and evaluation notes during the game and (ii) participant questionnaire after the game. All three countries showed similar results in learning experience during the collaboration processes in local policymaking. Specific learning experiences were related to: (i) the stakeholder network, (ii) interaction and (iii) relationships. The game also increased participant's understanding of group dynamics and need for a coordinator in policymaking. This exploratory study shows that the game provides participants with learning experiences during the collaboration process in policymaking. Experiencing what is needed to establish cross-sectoral collaboration is a first step towards enhancing knowledge exchange and more effective public health policies.
    • Legionella-uitbraak in Amsterdam: koeltoren als bron

      Hoek, J A R van den; IJzerman, E P F; Coutinho, Roel A (2006-08-19)
      During the period 6-28 July 2006, 30 confirmed cases of Legionella infection were identified in Amsterdam, 2 of which were fatal. All had a positive urinary antigen test, by which Legionella pneumophila serogroup I could be demonstrated. Consultations between the parties involved in the control of infectious diseases started on July 7th, as soon as it became clear that there was an outbreak. On July 10th it was established that relatively many of these patients lived in the eastern part of the city centre. After a study of the prevailing winds during the past 3 weeks, the search for installations containing water was started. A cooling tower in the town centre was closed on July 11th by way of precaution. During the following week, this tower was proven to be the source of the outbreak.
    • Legionellapreventie: betere naleving Waterleidingwet nodig

      Versteegh, A.; Brandsema, P.; Aa, M. van der; Dik, H. (Dekker en Nordemann, Rotterdam, 2007-11-01)
      Ongeveer 20 procent van de zorginstellingen en zwembaden heeft in 2005 te maken gehad met een legionellabesmetting in de leidingwaterinstallatie. Dit gold ook voor 5 procent van de hotels en campings. Vooral in zorginstellingen kan Legionella in de waterleidingen gevaarlijk zijn, omdat de mensen hier vaak een zwakkere gezondheid hebben. Circa 90% van de instellingen leeft niet alle wettelijk voorgeschreven preventiemaatregelen volledig na. Bij hercontrole is echter een groot deel van de problemen opgelost. Dit toont de effectiviteit en het belang van de controles: eenmaal op de hoogte van de risico’s zijn de eigenaren meestal bereid de nodige aanpassingen te doen. Het aantal collectieve leidingwaterinstallaties met Legionella nam tussen 2000 en 2006 niet duidelijk af. Een betere naleving van de legionellapreventie regelgeving en installatievoorschriften leidt naar verwachting wél tot minder Legionella in leidingwaterinstallaties. Tussen 2000 en 2006 steeg het aantal gemelde patiënten met legionellose. Een betrouwbare schatting van het aantal patiënten dat gerelateerd is aan een collectieve leidingwaterinstallatie als besmettingsbron is echter niet mogelijk.
    • Lessons and challenges in land change modeling derived from synthesis of cross-case comparisons.

      Pontius, RG; de Nijs, T; Castella, JC; Duan, Z; Fotsing, E (2019-03-13)
    • Let us empower the WFD to prevent risks of chemical pollution in European rivers and lakes

      Brack, W; Ait-Aissa, S; Altenburger, R; Cousins, I; Dulio, V; Escher, B; Focks, A; Ginebreda, A; Posthuma, L (2019-08-19)
    • Let's talk about sex: A qualitative study exploring the experiences of HIV nurses when discussing sexual risk behaviours with HIV-positive men who have sex with men.

      de Munnik, S; den Daas, C; Ammerlaan, H S M; Kok, G; Raethke, M S; Vervoort, S C J M (2017-11)
      Despite prevention efforts, the incidence of sexually transmitted infection among HIV-positive men who have sex with men remains high, which is indicative of unchanged sexual risk behaviour. Discussing sexual risk behaviour has been shown to help prevent sexually transmitted infections among HIV-positive men who have sex with men.
    • Leven de bodem: bodemorganismen onder de loep

      Rutgers, M; Peekel, A (2019-03-13)
    • A lifelong study of a pack Rhodesian ridgeback dogs reveals subclinical and clinical tick-borne Anaplasma phagocytophilum infections with possible reinfection or persistence.

      Hovius, Emil; de Bruin, Arnout; Schouls, Leo; Hovius, Joppe; Dekker, Niels; Sprong, Hein (2018-04-12)
      Various tick-borne infections often occur without specific clinical signs and are therefore notoriously hard to diagnose separately in veterinary practice. Longitudinal studies over multiple tick seasons performing clinical, serological and molecular investigations in parallel, may elucidate the relationship between infection and disease. In this regard, six related Rhodesian Ridgeback dogs living as a pack became subject of lifetime studies due to ongoing tick infestations and recurring clinical problems. Blood samples for diagnostic tests were obtained throughout the years 2000 to 2009.
    • Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.

      Aziz, Nadine M; Guedj, Faycal; Pennings, Jeroen L A; Olmos-Serrano, Jose Luis; Siegel, Ashley; Haydar, Tarik F; Bianchi, Diana W (2018-04-30)
      Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits and have delays in achieving developmental milestones. To determine whether different mouse models of DS recapitulate the human prenatal and postnatal phenotypes, here we directly compared brain histogenesis, gene expression, and behavior over the lifespan of three cytogenetically distinct mouse models of DS: Ts1Cje, Ts65Dn and Dp(16)1/Yey. Histological data indicated that Ts65Dn mice were the most consistently affected with respect to somatic growth, neurogenesis, and brain morphogenesis. Embryonic and adult gene expression results showed that Ts1Cje and Ts65Dn brains had considerably more differentially expressed (DEX) genes compared to Dp(16)1/Yey mice, despite the larger number of triplicated genes in the latter model. In addition, DEX genes showed little overlap in identity and chromosomal distribution in the three models, leading to dissimilarities in affected functional pathways. Perinatal and adult behavioral testing also highlighted differences among the models in their abilities to achieve various developmental milestones and perform hippocampal- and motor-based tasks. Interestingly, Dp(16)1/Yey mice showed no abnormalities in prenatal brain phenotypes, yet they manifested behavioral deficits starting at postnatal day 15 that continued through adulthood. In contrast, Ts1Cje mice showed mildly abnormal embryonic brain phenotypes, but only select behavioral deficits as neonates and adults. Altogether, our data showed widespread and unexpected fundamental differences in behavioral, gene expression, and brain development phenotypes between these three mouse models. Our findings illustrate unique limitations of each model when studying aspects of brain development and function in DS. This work helps to inform model selection in future studies investigating how observed neurodevelopmental abnormalities arise, how they contribute to cognitive impairment, and when testing therapeutic molecules to ameliorate the intellectual disability associated with DS.