• Bofuitbraken onder jongvolwassenen. Waarom ontstaan ze en wat kunnen we hieraan doen?

      Kaaijk, P; de Wit, J; Veldhuijzen, I; van Binnendijk, R (2019-10-03)
    • Bone markers and cardiovascular risk in type 2 diabetes patients.

      Zwakenberg, Sabine R; van der Schouw, Yvonne T; Schalkwijk, Casper G; Spijkerman, Annemieke M W; Beulens, Joline W J (2018-03-23)
      Vascular calcifications are associated with a three- to fourfold increased risk of cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients. Emerging evidence indicates that vascular calcification is a process of active bone formation regulated by stimulators and inhibitors of calcification. Therefore, this study aimed to evaluate whether six bone markers are associated with CVD risk in patients with type 2 diabetes.
    • Bordetella pertussis induces IFN-γ production by NK cells resulting in chemo-attraction by respiratory epithelial cells.

      den Hartog, Gerco; Schijf, Marcel A; Berbers, Guy A M; van der Klis, Fiona R M; Buisman, Anne-Marie (2020-03-27)
    • Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor.

      Hovingh, Elise Sofie; Mariman, Rob; Solans, Luis; Hijdra, Daniëlle; Hamstra, Hendrik-Jan; Jongerius, Ilse; van Gent, Marjolein; Mooi, Frits; Locht, Camille; Pinelli, Elena (2018-03-21)
      Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries represent up to 95% of recent clinical isolates. Knowledge on the effect that Prn deficiency has on infection and immunity to B. pertussis is crucial for the development of new strategies to control this disease. Here, we characterized the effect of Prn production by B. pertussis on human and murine dendritic cell (DC) maturation as well as in a murine model for pertussis infection. We incubated human monocyte-derived DCs (moDCs) with multiple isogenic Prn knockout (Prn-KO) and corresponding parental B. pertussis strains constructed either in laboratory reference strains with a Tohama I background or in a recently circulating clinical isolate. Results indicate that, compared to the parental strains, Prn-KO strains induced an increased production of pro-inflammatory cytokines by moDCs. This pro-inflammatory phenotype was also observed upon stimulation of murine bone marrow-derived DCs. Moreover, RNA sequencing analysis of lungs from mice infected with B. pertussis Prn-KO revealed increased expression of genes involved in cell death. These in vitro and in vivo findings indicate that B. pertussis strains which do not produce Prn induce a stronger pro-inflammatory response and increased cell death upon infection, suggesting immunomodulatory properties for Prn.
    • Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.

      Dorji, Dorji; Mooi, Frits; Yantorno, Osvaldo; Deora, Rajendar; Graham, Ross M; Mukkur, Trilochan K (2018-02)
      Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis. Despite induction of both antibody and cell-mediated immune (CMI) responses by aP and wP vaccines, there has been resurgence of pertussis in many countries in recent years. Possible reasons hypothesised for resurgence have ranged from incompliance with the recommended vaccination programmes with the currently used aP vaccine to infection with a resurged clinical isolates characterised by mutations in the virulence factors, resulting in antigenic divergence with vaccine strain, and increased production of pertussis toxin, resulting in dampening of immune responses. While use of these vaccines provide varying degrees of protection against whooping cough, protection against infection and transmission appears to be less effective, warranting continuation of efforts in the development of an improved pertussis vaccine formulations capable of achieving this objective. Major approaches currently under evaluation for the development of an improved pertussis vaccine include identification of novel biofilm-associated antigens for incorporation in current aP vaccine formulations, development of live attenuated vaccines and discovery of novel non-toxic adjuvants capable of inducing both antibody and CMI. In this review, the potential roles of different accredited virulence factors, including novel biofilm-associated antigens, of B. pertussis in the evolution, formulation and delivery of improved pertussis vaccines, with potential to block the transmission of whooping cough in the community, are discussed.
    • Bordetella pertussis-infected innate immune cells drive the anti-pertussis response of human airway epithelium.

      Kroes, M M; Miranda-Bedate, A; Jacobi, R H J; van Woudenbergh, E; den Hartog, G; van Putten, J P M; de Wit, J; Pinelli, E (2022-03-07)
    • BOREAS - A new MAX-DOAS profile retrieval algorithm for aerosols and trace gases.

      Bosch, T; Rozanov, V; Richter, A; Peters, E; Rozanov, A; Witrrock, F; Merlaud, A; van Berkhout, S (2019-01-14)
    • Borrelia burgdorferi is a poor inducer of interferon-gamma: amplification induced by interleukin-12.

      van de Schoor, F R; Vrijmoeth, H D; Brouwer, M A E; Ter Hofstede, H J M; Lemmers, H L M; Dijkstra, H; Boahen, C K; Oosting, M; Kullberg, B J; Hovius, J W; et al. (2022-02-07)
      Background Laboratory diagnosis of Lyme borreliosis (LB) is mainly based on serology, which has limitations, particularly in the early stages of the disease. In recent years there have been conflicting reports concerning a new diagnostic tool using the cytokine interferon-gamma (IFN-γ). Previous studies have generally found low concentrations of IFN-γ in early LB infection. The goal of this study is to investigate IFN-γ regulation during early LB and provide insights into the host response to B. burgdorferi. Methods We performed in vitro experiments with whole blood assays and peripheral blood mononuclear cells (PBMCs) of LB patients and healthy volunteers exposed to B. burgdorferi and evaluated the IFN-γ response using ELISA and related interindividual variation in IFN-γ production to the presence of single nucleotide polymorphisms. Results IFN-γ production of B. burgdorferi-exposed PBMCs and whole blood was amplified by the addition of IL-12 to the stimulation system. This effect was observed after 24 hours of B. burgdorferi stimulation in both healthy individuals and LB patients. The effect was highly variable between individuals, but was significantly higher in LB patients six weeks since the start of antibiotic treatment compared to healthy individuals. IL-12 p40 and IL-18 mRNA was upregulated upon exposure to B. burgdorferi, whereas IL-12 p35 and IFN-γ mRNA expression remained relatively unchanged. SNP Rs280520 in the downstream IL-12 pathway, Tyrosine Kinase 2, was associated with increased IFN-γ production. Conclusions This study shows that IL-12 evokes an IFN-γ response in B. burgdorferi exposed cells, and LB patients and healthy controls respond differently to this stimulation.
    • Borrelia miyamotoi Disease in an Immunocompetent Patient, Western Europe

      Hoornstra, Dieuwertje; Koetsveld, Joris; Sprong, Hein; Platonov, Alexander E.; Hovius, Joppe W. (2018-09)
    • Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men.

      Koetsveld, J; Platonov, A E; Kuleshov, K; Wagemakers, A; Hoornstra, D; Ang, W; Szekeres, S; van Duijvendijk, G L A; Fikrig, E; Embers, M E; et al. (2019-08-09)
    • Both non-smoking youth and smoking adults like sweet and minty e-liquid flavors more than tobacco flavor.

      Krüsemann, Erna J Z; van Tiel, Loes; Pennings, Jeroen L A; Vaessen, Wim; de Graaf, Kees; Talhout, Reinskje; Boesveldt, Sanne (2021-03-04)
    • Brain stem and cerebellar hyperintense lesions in migraine.

      Kruit, Mark C; Launer, Lenore J; Ferrari, Michel D; Buchem, Mark A van (2006-04-01)
      BACKGROUND AND PURPOSE: Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown. METHODS: Migraineurs with aura (n=161), without aura (n=134), and controls (n=140) from a population-based sample of adults (30 to 60 years of age) were evaluated with MRI. RESULTS: Infratentorial hyperintensities were identified in 13 of 295 (4.4%) migraineurs and in 1 of 140 (0.7%) controls (P=0.04). Twelve cases had hyperintensities, mostly bilaterally, in the dorsal basis pontis. Those with infratentorial hyperintensities also had supratentorial white matter lesions more often. CONCLUSIONS: We found an increased prevalence of infratentorial (mostly pontine) hyperintensities in migraineurs from the general population. This extends the knowledge about vulnerable brain regions and type of lesions in migraine brains. A hemodynamic ischemic pathogenesis is likely, but further research is needed.
    • Breaking Down Uncertain Risks for Risk Communication: A Conceptual Review of the Environmental Health Literature

      Jansen, Tom; Claassen, Liesbeth; van Poll, Ric; van Kamp, Irene; Timmermans, Daniëlle R. M. (2018-03)
    • Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies.

      Boekel, Laura; Stalman, Eileen W; Wieske, Luuk; Hooijberg, Femke; van Dam, Koos P J; Besten, Yaëlle R; Kummer, Laura Y L; Steenhuis, Maurice; van Kempen, Zoé L E; Killestein, Joep; et al. (2022-04-29)
    • Breast milk fatty acids and allergic disease in preschool children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study.

      Wijga, Alet H; Houwelingen, Adriana C van; Kerkhof, Marjan; Tabak, Cora; Jongste, Johan C de; Gerritsen, Jorrit; Boshuizen, Hendriek C; Brunekreef, Bert; Smit, Henriëtte A (2006-02-01)
      BACKGROUND: Better understanding of the association between early life lipid intakes and the development of allergic diseases is needed. OBJECTIVE: We prospectively studied breast milk content of n-6, n-3, and trans fatty acids in relation to allergic symptoms at the ages of 1 and 4 years. METHODS: Fatty acid content was determined in breast milk samples of 265 (158 allergic and 107 nonallergic) mothers of children participating in the Prevention and Incidence of Asthma and Mite Allergy study. Outcome variables studied were parental reported eczema at age 1 year, eczema at age 4 years, asthma at age 4 years, and, in a subgroup of 133 children, sensitization at age 4 years. RESULTS: In children of mothers with allergy, breast milk n-3 long chain polyunsaturated fatty acids and the ratio between n-3 and n-6 long chain polyunsaturated fatty acids were inversely associated with asthma and with persistent symptoms (eczema at age 1 year and eczema at age 4 years and/or asthma at age 4 years), but no associations between breast milk fatty acids and sensitization were observed. In children of mothers with allergy, also trans fatty acids tended to be inversely associated with allergic symptoms. In children of mothers without allergy, no associations between breast milk fatty acids and allergic symptoms were observed, but alpha-linolenic acid (18:3n-3) was positively associated with sensitization. CONCLUSION: In susceptible infants, the risk to develop allergic symptoms, but not the risk of sensitization, was modified by intake of n-3 long chain polyunsaturated fatty acids through breast milk.
    • Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis.

      van Rossem, Lenie; Smit, Henriette A; Armand, Martine; Bernard, Jonathan Y; Bisgaard, Hans; Bønnelykke, Klaus; Bruun, Signe; Heude, Barbara; Husby, Steffen; Kyhl, Henriette B; et al. (2020-06-20)
    • Breastfeeding and cardiometabolic markers at age 12: a population-based birth cohort study.

      Pluymen, L P M; Wijga, A H; Gehring, U; Koppelman, G H; Smit, H A; van Rossem, L (2019-03-18)
      There is growing evidence for a protective effect of breastfeeding against overweight and diabetes. It is less clear though, whether breastfed infants also have a more favorable cardiometabolic profile in childhood. We investigated whether children who were breastfed in infancy had more favorable cardiometabolic markers at 12 years of age than children who were never breastfed and received formula milk instead, and whether associations depended on the duration of breastfeeding. In 1509 participants of the population-based PIAMA birth cohort study, cardiometabolic markers were measured at 12 years of age. Duration of breastfeeding in weeks was assessed through parental questionnaires at 3 months and 1 year of age. Multivariable linear regression analysis was used to investigate associations of breastfeeding (any vs. never breastfeeding and duration of breastfeeding in categories <3 months, 3 to <6 months, and ≥6 months breastfeeding vs. never breastfeeding) with systolic and diastolic blood pressure (SBP and DBP, in Z-scores adjusted for age, sex, and height), total-to-high-density lipoprotein cholesterol (TC/HDLC), glycated hemoglobin (HbA1c, in mmol/mol), body mass index (BMI, in Z-scores adjusted for age and sex) and waist circumference (WC, in cm). Multivariable logistic regression was used to investigate the association of breastfeeding with odds of being overweight. 1288 of 1509 children (85.3%) received any breastmilk in infancy. Breastfed children had a lower SBP Z-score (-0.21 SD (≈ -2.29 mmHg), 95% CI -0.37, -0.06), a lower DBP Z-score (-0.10 SD (≈ -1.19 mmHg), 95% CI -0.20, -0.00), a smaller WC (-1.12 cm, 95% CI -2.20; -0.04), and lower odds of being overweight (OR 0.61, 95% CI 0.38, 0.97) than never breastfed children. These associations were not different between children with shorter and longer duration of breastfeeding. No statistically significant differences in TC/HDLC, HbA1c, and BMI were observed between breastfed and never breastfed children.
    • Bridging communities in the field of nanomedicine.

      Halamoda-Kenzaoui, Blanka; Baconnier, Simon; Bastogne, Thierry; Bazile, Didier; Boisseau, Patrick; Borchard, Gerrit; Borgos, Sven Even; Calzolai, Luigi; Cederbrant, Karin; Di Felice, Gabriella; et al. (2019-08-01)
    • Brief report: community-acquired Friedlander's pneumonia and pulmonary metastatic Klebsiella pneumoniae infection caused by hypervirulent ST23 in the Netherlands.

      Fliss, Monika; van den Berg, Charlotte H S B; Kuijper, Ed; Notermans, Daan W; Hendrickx, Antoni P A; Schoots, Mirthe H; Bathoorn, Erik (2022-07-05)