• Dutch trauma system performance: Are injured patients treated at the right place?

      Sturms, Leontien M; Driessen, Mitchell L S; van Klaveren, David; Ten Duis, Henk-Jan; Kommer, Geert Jan; Bloemers, Frank W; den Hartog, Dennis; Edwards, Michael J; Leenhouts, Peter A; van Zutphen, S; et al. (2021-05-16)
    • Duurzame zorg komt dubbel tot zijn recht.

      Zijp, M; Velders, G; Waaijers, S (2020-10-14)
    • Dynamic prediction model to identify young children at high risk of future overweight: Development and internal validation in a cohort study.

      Welten, Marieke; Wijga, Alet H; Hamoen, Marleen; Gehring, Ulrike; Koppelman, Gerard H; Twisk, Jos W R; Raat, Hein; Heymans, Martijn W; de Kroon, Marlou L A (2020-05-13)
      After backward selection in a Generalized Estimating Equations analysis, the prediction model included the baseline predictors maternal BMI, paternal BMI, paternal education, birthweight, sex, ethnicity and indoor smoke exposure; and the longitudinal predictors BMI SDS, and the linear and quadratic terms of the growth curve describing a child's BMI SDS development over time, as well as the longitudinal predictors' interactions with age. The area under the curve of the model after internal validation was 0.845 and Nagelkerke R2 was 0.351.
    • Dynamic prediction of childhood high blood pressure in a population-based birth cohort: a model development study.

      Hamoen, Marleen; Vergouwe, Yvonne; Wijga, Alet H; Heymans, Martijn W; Jaddoe, Vincent W V; Twisk, Jos W R; Raat, Hein; de Kroon, Marlou L A (2018-11-21)
      To develop a dynamic prediction model for high blood pressure at the age of 9-10 years that could be applied at any age between birth and the age of 6 years in community-based child healthcare. Data were used from 5359 children in a population-based prospective cohort study in Rotterdam, the Netherlands. High blood pressure was defined as systolic and/or diastolic blood pressure ≥95th percentile for gender, age and height. Using multivariable pooled logistic regression, the predictive value of characteristics at birth, and of longitudinal information on the body mass index (BMI) of the child until the age of 6 years, was assessed. Internal validation was performed using bootstrapping. 227 children (4.2%) had high blood pressure at the age of 9-10 years. Final predictors were maternal hypertensive disease during pregnancy, maternal educational level, maternal prepregnancy BMI, child ethnicity, birth weight SD score (SDS) and the most recent BMI SDS. After internal validation, the area under the receiver operating characteristic curve ranged from 0.65 (prediction at age 3 years) to 0.73 (prediction at age 5-6 years).
    • Dynamic Public Perceptions of the Coronavirus Disease Crisis, the Netherlands, 2020.

      de Vries, Marion; Claassen, Liesbeth; Te Wierik, Margreet J M; van den Hof, Susan; Brabers, Anne E M; de Jong, Judith D; Timmermans, Danielle R M; Timen, Aura (2021-01-25)
    • Dynamic release and transformation of metallic copper colloids in flooded paddy soil: Role of soil reducible sulfate and temperature.

      Xu, H; Xia, B; He, E; Qiu, R; Peijnenburg, WJGM; Qiu, H; Zhao, L; Xu, X; Cao, X (2020-07-12)
    • Dynamics of in azole-fungicide-containing plant waste, the Netherlands, 2016-2017.

      Zhang, Jianhua; Lopez Jimenez, Lidia; Snelders, Eveline; Debets, Alfons J M; Rietveld, Anton G; Zwaan, Bas J; Verweij, Paul E; Schoustra, Sijmen E (2020-10-30)
      The treatment of patients suffering from Aspergillus diseases is hampered due to infections with Aspergillus fumigatus that are already resistant to medical azoles. Previous work has suggested that A. fumigatus likely gains resistance through environmental azole exposure in so-called hotspots. Here, we investigated A. fumigatus resistance dynamics over time, at three sites at which farmers used azole fungicides for crop protection. Over 16 months 114 samples were taken from stockpiles of decaying plant waste. A. fumigatus and azole fungicide residues were ubiquitously present in the plant waste. On average 105A. fumigatus CFU/g was recovered of which roughly half were itraconazole and tebuconazole resistant. Similar tandem repeat-mediated resistance mechanisms were found in colonies cultured from plant waste as reported in clinical azole-resistant isolates. Our results show a consistent high burden of azole-resistant A. fumigatus in azole-containing plant waste and underscores the need to further investigate resistance-reducing interventions and transmission routes.ImportanceAspergillus fumigatus is consistently present independently on season at a high abundance in plant-waste material throughout sampling period. Our study confirmed that long-term storage of azole-containing decaying plant material indeed be considered hotspots, which can sustain resistance development and maintenance in A. fumigatus Roughly half of individual isolates were azole-resistant and carry genetic mutations that are highly similar to those found in patients with azole-resistant invasive aspergillosis. Our work suggests that environmental sources of azole resistance in A. fumigatus might be important, underscoring the need for further studies on environment-to-patient transmission routes.
    • Dynamics of intestinal carriage of Extended-spectrum Beta-lactamase producing Enterobacteriaceae in the Dutch general population (2014-2016).

      van den Bunt, Gerrita; Fluit, Ad C; Bootsma, Martin C J; Duijkeren, Engeline van; Scharringa, Jelle; Pelt, Wilfrid van; Bonten, Marc J M (2019-11-05)
    • Dynamics of the Antibody Response After a Third Dose of Measles-Mumps-Rubella Vaccine Indicate a Slower Decline Compared With a Second Dose.

      Kaaijk, Patricia; Nicolaie, M Alina; van Rooijen, Debbie; van Houten, Marianne A; van der Klis, Fiona R; Buisman, Anne-Marie; van Binnendijk, Rob S (2020-10-20)
    • E-cigarette and waterpipe use in two adolescent cohorts: cross-sectional and longitudinal associations with conventional cigarette smoking.

      Treur, Jorien L; Rozema, Andrea D; Mathijssen, Jolanda J P; van Oers, Hans; Vink, Jacqueline M (2017-12-19)
      Alternative tobacco products are increasing in popularity. An important question is whether their use is associated with or even leads to conventional smoking, but large-scale (European) studies are scarce. In two cohorts of Dutch adolescents (Cohort I n = 6819, mean age = 13.8 SD = 1.1, 48.2% female; Cohort II n = 2758, mean age = 17.3 SD = 1.8, 61.3% female), we investigated use of electronic (e)-cigarettes with nicotine, e-cigarettes without nicotine and waterpipe. Generalized estimating equation modelling was conducted with ever conventional smoking as the dependent variable (0 = no, 1 = yes) and ever alternative tobacco use as the independent variable, correcting for clustering within schools, age, sex and education in both cohorts. In a subsample (n = 2100), the association between alternative tobacco use at baseline and conventional smoking 6 months later was tested, taking into account smoking propensity (based on personality, susceptibility to peer pressure and smoking intentions). Ever use prevalence was 13.7% for e-cigarettes with nicotine, 29.4% for e-cigarettes without nicotine and 22.1% for waterpipe in Cohort I and 12.3, 27.6 and 45.3% respectively in Cohort II. Ever smokers had tried alternative tobacco products more often than never smokers. Among never-smoking adolescents at baseline, alternative tobacco use predicted ever smoking 6 months later (e-cigarettes with nicotine OR 11.90 95% CI 3.36-42.11; e-cigarettes without nicotine OR 5.36 95% CI 2.73-10.52; waterpipe OR 5.36 95% CI 2.78-10.31). This association was strongest for adolescents with a low baseline risk of smoking. Experimenting with alternative tobacco products is common among Dutch youth. Alternative tobacco use predicts (future) smoking, especially among adolescents with a low smoking propensity.
    • E-Liquid Flavor Preferences and Individual Factors Related to Vaping: A Survey among Dutch Never-Users, Smokers, Dual Users, and Exclusive Vapers.

      Romijnders, Kim Agj; Krüsemann, Erna Jz; Boesveldt, Sanne; Graaf, Kees de; Vries, Hein de; Talhout, Reinskje (2019-11-22)
      Appealing product characteristics, such as flavors, may stimulate e-cigarette use. While switching to e-cigarettes may reduce harm for smokers, concerns exist about e-cigarette use among never-smokers. The role of flavors in the decision to switch to or refrain from vaping is unclear. This study used a bottom-up approach to investigate the relation between flavor preferences and individual factors related to vaping between various user groups. A cross-sectional survey was conducted among never-users (n = 407), smokers (n = 138), dual users (n = 122), and exclusive vapers (n = 61) in the Netherlands. Demographics, attractiveness of product characteristics, flavor preferences, and individual factors related to vaping (knowledge, trust, perceived susceptibility, attitude, social influence, deliberation, and intention) were assessed. The availability of different flavors was the most attractive characteristic of e-cigarettes. Dual users and exclusive vapers had most often used tobacco and menthol/mint flavors when they first started vaping. Compared to dual users, exclusive vapers currently used more fruit and sweet flavors. Never-users who were interested in trying an e-liquid flavor had more knowledge about and a more positive attitude towards e-cigarettes. Smokers who were interested in trying a flavor had a more positive attitude towards e-cigarettes and experienced the social influence towards not using e-cigarettes as less strong than those who did not want to try any flavor. Hence, individual factors related to vaping differed depending on whether never-users and smokers wanted to try an e-liquid flavor. This means that flavors may moderate differences found in individual factors related to vaping, or vice versa.
    • An E-liquid Flavor Wheel: A Shared Vocabulary based on Systematically Reviewing E-liquid Flavor Classifications in Literature.

      Krüsemann, Erna Johanna Zegerina; Boesveldt, Sanne; de Graaf, Kees; Talhout, Reinskje (2018-05-18)
      E-liquids are available in a high variety of flavors. A systematic classification of e-liquid flavors is necessary to increase comparability of research results. In the food, alcohol and fragrance industry, flavors are classified using flavor wheels. We systematically reviewed literature on flavors related to e-cigarette use, to investigate how e-liquid flavors have been classified in research, and propose an e-liquid flavor wheel to classify e-liquids based on marketing descriptions.
    • Early childhood infections and body mass index in adolescence.

      Prins-van Ginkel, Annemarijn C; Wijga, Alet H; Bruijning-Verhagen, Patricia C J; Brunekreef, Bert; Gehring, Ulrike; van der Hoek, Wim; Koppelman, Gerard H; van Rossem, Lenie; van der Sande, Marianne A B; Smit, Henriëtte A (2021-03-26)
    • Early environmental quality and life-course mental health effects: The Equal-Life project

      van Kamp, I; Waye, KP; Kanninen, K; Gulliver, J; Bozzon, A; Psyllidis, A; Boshuizen, H; et al. (2022-01-18)
    • Early introduction of complementary foods and childhood overweight in breastfed and formula-fed infants in the Netherlands: the PIAMA birth cohort study.

      Pluymen, Linda P M; Wijga, Alet H; Gehring, Ulrike; Koppelman, Gerard H; Smit, Henriëtte A; van Rossem, L (2018-02-22)
      To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants.
    • Early Life Microbiota and Respiratory Tract Infections.

      de Steenhuijsen Piters, Wouter A A; Binkowska, Justyna; Bogaert, Debby (2020-08-12)
    • Early measles vaccination during an outbreak in The Netherlands: reduced short and long-term antibody responses in children vaccinated before 12 months of age.

      Brinkman, Iris D; de Wit, Jelle; Smits, Gaby P; Ten Hulscher, Hinke I; Jongerius, Maria C; Abreu, Taymara C; van der Klis, Fiona R M; Hahné, Susan J M; Koopmans, M P G; Rots, Nynke Y; et al. (2019-04-11)
      The majority of infants will not be protected by maternal antibodies until their first measles vaccination between 12-15 months of age. This provides incentive to reduce the age of measles vaccination, but immunological consequences are insufficiently understood and long-term effects are largely unknown. Infants who received early measles vaccination between 6-12 months and a second dose at 14 months of age (n=79) were compared with a control group who received one dose at 14 months of age (n=44). Measles-neutralizing antibody concentrations and avidity were determined up to 4 years of age. Infants with a first measles vaccination administered before 12 months of age show long-term reduced measles-neutralizing antibody concentrations and avidity compared to the control group. For 11.1% of children with a first dose before 9 months of age, antibody levels had dropped below the cutoff for clinical protection at 4 years of age. Early measles vaccination provides immediate protection in the majority of infants, but long-term neutralizing antibody responses are reduced compared to infants vaccinated at a later age. Additional vaccination at 14 months of age does not improve this. Long-term, this may result in an increasing number of children susceptible to measles.
    • Early origins of lung disease: towards an interdisciplinary approach.

      Ubags, Niki D J; Alejandre Alcazar, Miguel A; Kallapur, Suhas G; Knapp, Sylvia; Lanone, Sophie; Lloyd, Clare M; Morty, Rory E; Pattaroni, Céline; Reynaert, Niki L; Rottier, Robbert J; et al. (2020-09-30)