• Login
    Search 
    •   Home
    • Articles and other publications by RIVM employees
    • Search
    •   Home
    • Articles and other publications by RIVM employees
    • Search
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WARPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartmentThis CommunityTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartment

    My Account

    LoginRegister

    Filter by Category

    SubjectsMortality (2)B/Yamagata (1)Borrelia miyamotoi disease (1)Complications (1)Coxiella burnetii (1)View MoreJournal
    Clin Microbiol Infect 2019; advance online publication (ahead of print) (4)
    AuthorsAdlhoch, Cornelia (1)Andrews, Nick (1)Ang, W (1)Anthony, Richard (1)Asikainen, Tommi (1)View MoreYear (Issue Date)2019 (3)2018 (1)Types
    Article (4)

    Statistics

    Display statistics
     

    Search

    Show Advanced FiltersHide Advanced Filters

    Filters

    Now showing items 1-4 of 4

    • List view
    • Grid view
    • Sort Options:
    • Relevance
    • Title Asc
    • Title Desc
    • Issue Date Asc
    • Issue Date Desc
    • Results Per Page:
    • 5
    • 10
    • 20
    • 40
    • 60
    • 80
    • 100

    • 4CSV
    • 4RefMan
    • 4EndNote
    • 4BibTex
    • Selective Export
    • Select All
    • Help
    Thumbnail

    Role and value of whole genome sequencing in studying tuberculosis transmission.

    Nikolayevskyy, Vlad; Niemann, Stefan; Anthony, Richard; Van Soolingen, Dick; Tagliani, Elisa; Ködmön, Csaba; van der Werf, Marieke J; Cirillo, Daniela Maria (2019-04-10)
    Tuberculosis (TB) remains a serious public health threat worldwide. Theoretically ultimate resolution of whole genome sequencing (WGS) for Mycobacterium tuberculosis complex (MTBC) strain classification makes this technology very attractive for epidemiological investigations. To summarise the evidence available in peer-reviewed publications on the role and place of WGS in detection of TB transmission. 69 peer-reviewed publications identified in Pubmed database. Evidence from >30 publications suggests that a cut-off value of <6 single nucleotide polymorphisms (SNPs) between strains efficiently excludes cases that are not the result of recent transmission and could be used for the identification of drug-sensitive isolates involved in direct human-to-human TB transmission. Sensitivity of WGS to identify epidemiologically linked isolates is high reaching 100% in eight studies with specificity (17 - 95%) highly dependent on the settings. Drug resistance and specific phylogenetic lineages may be associated with accelerated mutation rates affecting genetic distances. WGS can be potentially used to distinguish between true relapses and re-infections but in high-incidence low-diversity settings this would require consideration of epidemiologic links and minority alleles. Data from four studies looking into within host diversity highlight a need for developing criteria for acceptance or rejection of WGS relatedness results depending on the proportion of minority alleles.
    Thumbnail

    European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

    Nielsen, Jens; Vestergaard, Lasse S; Richter, Lukas; Schmid, Daniela; Bustos, Natalia; Asikainen, Tommi; Trebbien, Ramona; Denissov, Gleb; Innos, Kaire; Virtanen, Mikko J; et al. (2019-02-18)
    Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excl. Russia and the Turkey part of European, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
    Thumbnail

    Chronic Q fever-related complications and mortality: data from a nationwide cohort.

    van Roeden, S E; Wever, P C; Kampschreur, L M; Gruteke, P; Van Der Hoek, W; Hoepelman, A I M; Bleeker-Rovers, C P; Oosterheert, J J (2018-12-10)
    Chronic infection with Coxiella burnetii (chronic Q fever) can cause life-threatening conditions such as endocarditis, infected vascular prostheses, and infected arterial aneurysms. We aimed to assess prognosis of chronic Q fever patients in terms of complications and mortality. A large cohort of chronic Q fever patients was assessed to describe complications, overall mortality and chronic Q fever-related mortality. Chronic Q fever-related mortality was expressed as a case fatality rate (number of chronic Q fever-related deaths/number of chronic Q fever patients). Complications occurred in 166 of 439 (38%) chronic Q fever patients: in 61% of proven (153/249), 15% of probable (11/74), and 2% of possible chronic Q fever patients (2/116). Most frequently observed complications were acute aneurysms (14%), heart failure (13%), and non-cardiac abscesses (10%). Overall mortality was 38% (94/249) for proven chronic Q fever patients (median follow-up 3.6 years) and 22% (16/74) for probable chronic Q fever patients (median follow-up 4.7 years). The case fatality rate was 25% for proven (63/249) chronic Q fever patients and 4% for probable (3/74) chronic Q fever patients. Overall survival was significantly lower in patients with complications, compared to those without complications (p <0.001). In chronic Q fever patients, complications occur frequently and contribute to the mortality rate. Patients with proven chronic Q fever have the highest risk of complications and chronic Q fever-related mortality. Prognosis for patients with possible chronic Q fever is favourable in terms of complications and mortality.
    Thumbnail

    Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men.

    Koetsveld, J; Platonov, A E; Kuleshov, K; Wagemakers, A; Hoornstra, D; Ang, W; Szekeres, S; van Duijvendijk, G L A; Fikrig, E; Embers, M E; et al. (2019-08-09)
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.