Now showing items 1-20 of 2986

    • Decision-making, barriers, and facilitators regarding cervical cancer screening participation among Turkish and Moroccan women in the Netherlands: a focus group study.

      Hamdiui, Nora; Marchena, Eline; Stein, Mart L; van Steenbergen, Jim E; Crutzen, Rik; van Keulen, Hilde M; Reis, Ria; van den Muijsenbergh, Maria E T C; Timen, Aura (2021-01-07)
      Six focus group discussions were conducted between March and April 2019 with Turkish (n = 24) and Moroccan (n = 20) women in the Netherlands, aged 30-60 years. Questions were based on an extended version of the Health Belief Model. Discussions were transcribed verbatim and thematically analysed.
    • A widening gap between boys and girls in musculoskeletal complaints, while growing up from age 11 to age 20 - The PIAMA Birth Cohort Study.

      Picavet, H Susan J; Gehring, Ulrike; van Haselen, Amanda; Koppelman, Gerard H; van de Putte, Elise M; Vader, Sarah; van der Wouden, J Hans C; Schmits, Ruben J H; Smit, Henriette A; Wijga, Alet (2021-01-06)
    • Correction to: Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes.

      Braver, Nicolette R den; Rutters, Femke; van der Spek, Andrea L J Kortlever; Ibi, Dorina; Looman, Moniek; Geelen, Anouk; Elders, Petra; van der Heijden, Amber A; Brug, Johannes; Lakerveld, Jeroen; et al. (2021-01-05)
    • Reflections on key methodological decisions in national burden of disease assessments.

      Von der Lippe, Elena; Devleesschauwer, Brecht; Gourley, Michelle; Haagsma, Juanita; Hilderink, Henk; Porst, Michael; Wengler, Annelene; Wyper, Grant; Grant, Ian (2020-12-31)
    • Relevance of Transcriptomics for Mode of Action Assessment.

      Luijten, Mirjam; Wackers, Paul F K; Rorije, Emiel; Pennings, Jeroen L A; Heusinkveld, Harm J (2020-12-30)
      Recently, we reported an in vitro toxicogenomics comparison approach to categorize chemical substances according to similarities in their proposed toxicological modes of action. Use of such an approach for regulatory purposes requires, among others, insight into the extent of biological concordance between in vitro and in vivo findings. To that end, we applied the comparison approach to transcriptomics data from the Open TG-GATEs database for 137 substances with diverging modes of action and evaluated the outcomes obtained for rat primary hepatocytes and for rat liver. The results showed that a relatively small number of matches observed in vitro were also observed in vivo, whereas quite a large number of matches between substances were found to be relevant solely in vivo or in vitro. The latter could not be explained by physicochemical properties, leading to insufficient bioavailability or poor water solubility. Nevertheless, pathway analyses indicated that for relevant matches the mechanisms perturbed in vitro are consistent with those perturbed in vivo. These findings support the utility of the comparison approach as tool in mechanism-based risk assessment.
    • Clients' perspectives on the quality of counseling for prenatal anomaly screening. A comparison between 2011 and 2019.

      Martin, Linda; Gitsels-van der Wal, Janneke T; Hitzert, Marit; Henrichs, Jens (2020-12-30)
      We used the validated 57-item QUOTEprenatal questionnaire, to measure clients' counseling preferences and experiences before and after counseling in 20 obstetric organizations throughout the Netherlands. Clients' preferences and experiences were compared between pregnant women and partners, nulliparous versus multiparous clients and between results of a Dutch survey in 2011 and the current one.
    • Prediction of mortality and major cardiovascular complications in type 2 diabetes: external validation of UKPDS outcomes model version 2 in two European observational cohorts.

      Pagano, Eva; Konings, Stefan Ra; Di Cuonzo, Daniela; Rosato, Rosalba; Bruno, Graziella; van der Heijden, Amber A; Beulens, Joline; Slieker, Roderick; Leal, Jose; Feenstra, Talitha L (2020-12-29)
    • Vaccination attitudes, beliefs and behaviours among primary health care workers in northern Croatia.

      Tomljenovic, Morana; Petrovic, Goranka; Antoljak, Nataša; Hansen, Lisa (2020-12-29)
    • Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System.

      Bischoff, Nicolaj S; de Kok, Theo M; Sijm, Dick T H M; van Breda, Simone G; Briedé, Jacco J; Castenmiller, Jacqueline J M; Opperhuizen, Antoon; Chirino, Yolanda I; Dirven, Hubert; Gott, David; et al. (2020-12-28)
      Titanium dioxide (TiO2) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO2 and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO2 warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO2, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO2 and nano-sized TiO2 in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO2.
    • Multiple stressors determine river ecological status at the European scale: Towards an integrated understanding of river status deterioration.

      Lemm, Jan U; Venohr, Markus; Globevnik, Lidija; Stefanidis, Kostas; Panagopoulos, Yiannis; van Gils, Jos; Posthuma, Leo; Kristensen, Peter; Feld, Christian K; Mahnkopf, Judith; et al. (2020-12-28)
    • Towards an ecosystem service-based method to quantify the filtration services of mussels under chemical exposure.

      Wang, Jiaqi; Koopman, K Remon; Collas, Frank P L; Posthuma, Leo; de Nijs, Ton; Leuven, Rob S E W; Hendriks, A Jan (2020-12-25)
      As filter-feeders, freshwater mussels provide the ecosystem service (ES) of biofiltration. Chemical pollution may impinge on the provisioning of mussels' filtration services. However, few attempts have been made to estimate the impacts of chemical mixtures on mussels' filtration capacities in the field, nor to assess the economic benefits of mussel-provided filtration services for humans. The aim of the study was to derive and to apply a methodology for quantifying the economic benefits of mussel filtration services in relation to chemical mixture exposure. To this end, we first applied the bootstrapping approach to quantify the filtration capacity of dreissenid mussels when exposed to metal mixtures in the Rhine and Meuse Rivers in the Netherlands. Subsequently, we applied the value transfer method to quantify the economic benefits of mussel filtration services to surface water-dependent drinking water companies. The average mixture filtration inhibition (filtration rate reduction due to exposure to metal mixtures) to dreissenids was estimated to be <1% in the Rhine and Meuse Rivers based on the measured metal concentrations from 1999 to 2017. On average, dreissenids on groynes were estimated to filter the highest percentage of river discharge in the Nederrijn-Lek River (9.1%) and the lowest in the Waal River (0.1%). We estimated that dreissenid filtration services would save 110-12,000 euros/million m3 for drinking water production when abstracting raw water at the end of respective rivers. Economic benefits increased over time due to metal emission reduction. This study presents a novel methodology for quantifying the economic benefits of mussel filtration services associated with chemical pollution, which is understandable to policymakers. The derived approach could potentially serve as a blueprint for developing methods in examining the economic value of other filter-feeders exposed to other chemicals and environmental stressors. We explicitly discuss the uncertainties for further development and application of the method.
    • Performance Evaluation of Handheld Raman Spectroscopy for Cocaine Detection in Forensic Case Samples.

      Kranenburg, Ruben F; Verduin, Joshka; de Ridder, Renee; Weesepoel, Yannick; Alewijn, Martin; Heerschop, Marcel; Keizers, Peter H J; van Esch, Annette; van Asten, Arian C (2020-12-23)
      Handheld Raman spectroscopy is an emerging technique for rapid on-site detection of drugs-of-abuse. Most devices are developed for on-scene operation with a user interface that only shows whether cocaine has been detected. Extensive validation studies are unavailable, and so are typically the insight in raw spectral data and the identification criteria. This work evaluates the performance of a commercial handheld Raman spectrometer for cocaine detection based on i) its performance on 0 - 100 (wt)% binary cocaine mixtures, ii) retrospective comparison of 3168 case samples from 2015 - 2020 analyzed by both GC-MS and Raman, iii) assessment of spectral selectivity and iv) comparison of the instrument's on-screen results with combined Partial Least Square Regression (PLS-R) and Discriminant Analysis (PLS-DA) models. The limit of detection was dependent on sample composition and varied between 10 - 40 % cocaine. Since the average cocaine content in street samples is well above this limit, a 97.5 % true positive rate was observed in case samples. No cocaine false positives were reported although 12.5% of the negative samples were initially reported as inconclusive by the built-in software. The spectral assessment showed high selectivity for Raman peaks at 1712 cm-1 (cocaine base) and 1716 cm-1 (cocaine HCl). Combined PLS-R and PLS-DA models using these features confirmed and further improved instrument performance. This study scientifically assessed the performance of a commercial Raman spectrometer, providing useful insight on its applicability for both presumptive detection and legally valid evidence of cocaine presence for law enforcement.
    • Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.

      Bakker, Mark K; van der Spek, Rick A A; van Rheenen, Wouter; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C; Alg, Varinder S; van Eijk, Kristel R; Koido, Masaru; Akiyama, Masato; et al. (2020-12-22)
    • Development of a Comparative European Orthohantavirus Microneutralization Assay With Multi- Species Validation and Evaluation in a Human Diagnostic Cohort.

      Hoornweg, Tabitha E; Zutt, Ilse; de Vries, Ankje; Maas, Miriam; Hoogerwerf, Marieke N; Avšič-Županc, Tatjana; Korva, Miša; Reimerink, Johan H J; Reusken, Chantal B E M (2020-12-22)
      Orthohantaviruses (family Hantaviridae, order Bunyavirales) can cause two serious syndromes in humans: hemorrhagic fever with renal syndrome (HFRS), associated with the Old World orthohantaviruses, and hantavirus cardiopulmonary syndrome (HCPS), associated with orthohantaviruses in the Americas. In Europe, four different orthohantaviruses (DOBV, PUUV, SEOV, and TULV) are associated with human disease. As disease severity and zoonotic source differ between orthohantavirus species, conclusive determination of the infecting species by either RT-PCR or comparative virus neutralization test (VNT) is of importance. Currently, the focus reduction neutralization test (FRNT) is considered the 'Gold Standard' for orthohantavirus VNTs, however this test is laborious and time-consuming. Consequently, more high-throughput alternatives are needed. In this study, we developed a comparative orthohantavirus microneutralization test (MNT) including all four human pathogenic orthohantavirus species circulating in Europe. The assay was validated using RT-PCR-confirmed rodent (n=17) and human sera (n=17), DOBV-suspected human sera (n=3) and cohorts of orthohantavirus-negative rodent (n=3) and human sera (n=85). 16/17 RT-PCR-confirmed rodent sera and 18/20 of the RT-PCR-confirmed and DOBV-suspected human sera were serotyped successfully, while for the remaining rodent (n=1) and human sera (n=2) no neutralizing titers could be detected. All negative control sera tested negative in the MNT. The assay was subsequently evaluated using a clinical cohort of 50 orthohantavirus patients. Orthohantavirus infection was confirmed in all 50 patients, and 47/50 (94%) sera were serotyped successfully, confirming PUUV as the major cause of orthohantavirus infections in Netherlands. Notably, two previously unrecognized SEOV cases from 2013 were diagnosed using the MNT, underlining the added value of the MNT in a diagnostic setting. In conclusion, we demonstrate the successful development and clinical implementation of a comparative European orthohantavirus MNT to determine the infecting virus species in European HFRS patients. Identification of the causative species is needed for an adequate Public Health response and can support individual patient care. For many labs, the implementation of orthohantavirus neutralization tests has not been a straightforward procedure. This issue will be addressed by the rollout of the comparative MNT to multiple European laboratories to support patient diagnostics, surveillance and Public Health responses.
    • HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study.

      Smit, Colette; Boyd, Anders; Rijnders, Bart J A; van de Laar, Thijs J W; Leyten, Eliane M; Bierman, Wouter F; Brinkman, Kees; Claassen, Mark A A; den Hollander, Jan; Boerekamps, Anne; et al. (2020-12-22)
    • Universal risk assessment upon hospital admission for screening of carriage with multidrug-resistant microorganisms (MDRO) in a Dutch tertiary care centre (2016 - 2019).

      van Hout, Denise; Bruijning-Verhagen, Patricia C J; Blok, Hetty; Troelstra, Annet; Bonten, Marc J M (2020-12-18)
      We performed a cross-sectional study using routine healthcare data in a Dutch tertiary hospital between January 1st 2015 and August 1st 2019. MDRO risk assessment upon hospitalization included assessment of: known MDRO carriage, previous hospitalization in another Dutch hospital during an outbreak or a foreign hospital, living in an asylum centre, exposure to livestock farming and household membership of a methicillin-resistant Staphylococcus aureus carrier.
    • Assessing Human Exposure to SVOCs in Materials, Products, and Articles: A Modular Mechanistic Framework.

      Eichler, Clara M A; Hubal, Elaine A Cohen; Xu, Ying; Cao, Jianping; Bi, Chenyang; Weschler, Charles J; Salthammer, Tunga; Morrison, Glenn C; Koivisto, Antti Joonas; Zhang, Yinping; et al. (2020-12-15)
    • Annual dynamics of antimicrobials and resistance determinants in flocculent and aerobic granular sludge treatment systems.

      Pallares-Vega, Rebeca; Hernandez Leal, Lucia; Fletcher, Benjamin N; Vias-Torres, Eduardo; van Loosdrecht, Mark C M; Weissbrodt, David G; Schmitt, Heike (2020-12-15)
      The occurrence and removal patterns of 24 antimicrobial agents and antimicrobial resistant determinants namely 6 antibiotic resistance genes (ARGs) and 2 mobile genetic elements (MGEs), and the fecal indicator E. coli were investigated in three full-scale wastewater treatment plants. Their waterlines and biosolids lines (including secondary treatment based on both granular and activated sludge) were sampled monthly throughout one year. Samples were analyzed by means of LC-MS/MS, qPCR and cell enumeration, respectively. The influence of rainfall, temperature, and turbidity on the occurrence and removal of the aforementioned agents was assessed through statistical linear mixed models. Ten of the antimicrobial agents (macrolides, fluoroquinolones, tetracyclines, and sulfonamides) were commonly found in influent in concentrations of 0.1-2 µg L-1, and the predominant ARGs were ermB and sul1 (6.4 and 5.9 log10 mL-1 respectively). Warmer temperatures slightly reduced gene concentrations in influent whilst increasing that of E. coli and produced an uneven effect on the antimicrobial concentrations across plants. Rainfall diluted both E. coli (-0.25 logs, p < 0.001) and antimicrobials but not genes. The wastewater treatment reduced the absolute abundance of both genes (1.86 logs on average) and E. coli (2.31 logs on average). The antimicrobials agents were also partly removed, but 8 of them were still detectable after treatment, and 6 accumulated in the biosolids. ARGs were also found in biosolids with patterns resembling those of influent. No significant differences in the removal of antimicrobials, genes and E. coli were observed when comparing conventional activated sludge with aerobic granular sludge. Irrespective of the type of sludge treatment, the removal of genes was significantly reduced with increasing hydraulic loads caused by rainfall (-0.35 logs per ∆ average daily flow p < 0.01), and slightly decreased with increasing turbidity (-0.02 logs per ∆1 nephelometric turbidy unit p < 0.05) .