• Zieke hazen in het veld

      Montizaan M; Mulder A (2017-04-30)
    • Zika virus en seksuele transmissie.

      Duijster, J W; Brandwagt, D A H; Timen, A; van der Eijk, A A; Vennema, H; Te Wierik, M J M (2017)
      - More evidence has become available concerning the sexual transmission of Zika virus and viral shedding in semen, which has led to the expansion of international guidelines for prevention of sexual transmission; Dutch guidelines have not been altered.- Internationally, the use of condoms during sex or sexual abstinence is advised for the duration of the pregnancy. Furthermore, when actively trying to conceive one should use a condom for six months.- In the Dutch guidelines, men who have visited a Zika virus epidemic area are advised to use a condom for 2 months upon return, irrespective of their partner possibly being pregnant or their wish to conceive.- Based on reports to the World Health Organisation and patient reports, the serial interval between disease onsets of both sexual partners is 4-44 days (median: 15).- Zika virus RNA is often no longer detectable in semen 2-3 months after disease onset.- International guidelines are based on the maximum detection period of Zika virus RNA and on virus isolation. Dutch prevention guidelines, on the other hand, are based on the longest serial interval known for sexual transmission (44 days).- Detection of Zika virus RNA in semen does not give a definitive answer on contagiousness. Currently, following the Dutch prevention advice is the best option in order to prevent sexual transmission.
    • Zikavirusdiagnostiek; de (on)zin van uitgebreide serologische algoritmes bij zwangeren)

      Reusken C; Rockx B; Geurts van Kessel C; Pas S; Tienen C van; Kampen J van; Koopmans M; Eijk A van der (2016-06)
    • Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project.

      Giacconi, Robertina; Costarelli, Laura; Piacenza, Francesco; Basso, Andrea; Bürkle, Alexander; Moreno-Villanueva, Maria; Grune, Tilman; Weber, Daniela; Stuetz, Wolfgang; Gonos, Efstathios S; Schön, Christiane; Grubeck-Loebenstein, Beatrix; Sikora, Ewa; Toussaint, Olivier; Debacq-Chainiaux, Florence; Franceschi, Claudio; Hervonen, Antti; Slagboom, Eline; Ciccarone, Fabio; Zampieri, Michele; Caiafa, Paola; Jansen, Eugène; Dollé, Martijn E T; Breusing, Nicolle; Mocchegiani, Eugenio; Malavolta, Marco (2017-10-17)
      Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO). We found that the lymphocyte capability to induce MT in response to Zn is not affected by aging. However, GO participants showed lower Zn-induced MT and increased basal expression of MT1A, MT1X and ZnT-1 genes than RASIG subjects. Moreover, Zn-induced MT levels were found to be inversely related with oxidative stress markers (plasma protein carbonyls, 3-nitrotyrosine and malondialdehyde) in the whole population, but not in GO subjects.In conclusion, our results support the hypothesis that the response to Zn is attenuated in PBMCs of centenarian offspring compared to the general population as a consequence of a tighter control of Zn homeostasis which is likely to provide them constant protection against stress stimuli over the whole lifespan.
    • Zoonotic bacteria and parasites found in raw meat-based diets for cats and dogs.

      van Bree, Freek P J; Bokken, Gertie C A M; Mineur, Robin; Franssen, Frits; Opsteegh, Marieke; van der Giessen, Joke W B; Lipman, Len J A; Overgaauw, Paul A M (2018-01-13)
      Feeding raw meat-based diets (RMBDs) to companion animals has become increasingly popular. Since these diets may be contaminated with bacteria and parasites, they may pose a risk to both animal and human health. The purpose of this study was to test for the presence of zoonotic bacterial and parasitic pathogens in Dutch commercial RMBDs. We analysed 35 commercial frozen RMBDs from eight different brands. Escherichia coli serotype O157:H7 was isolated from eight products (23 per cent) and extended-spectrum beta-lactamases-producing E coli was found in 28 products (80 per cent). Listeria monocytogenes was present in 19 products (54 per cent), other Listeria species in 15 products (43 per cent) and Salmonella species in seven products (20 per cent). Concerning parasites, four products (11 per cent) contained Sarcocystis cruzi and another four (11 per cent) S tenella In two products (6 per cent) Toxoplasma gondii was found. The results of this study demonstrate the presence of potential zoonotic pathogens in frozen RMBDs that may be a possible source of bacterial infections in pet animals and if transmitted pose a risk for human beings. If non-frozen meat is fed, parasitic infections are also possible. Pet owners should therefore be informed about the risks associated with feeding their animals RMBDs.
    • Zoonotic Infection with Pigeon Paramyxovirus Type 1 linked to Fatal Pneumonia.

      Kuiken, Thijs; Breitbart, Mya; Beer, Martin; Grund, Christian; Höper, Dirk; van den Hoogen, Bernadette; Kerkhoffs, Jean-Louis H; Kroes, Aloys C M; Rosario, Karyna; van Run, Peter; Schwarz, Matthias; Svraka, Sanela; Teifke, Jens; Koopmans, Marion (2018-01-24)
      The characteristics and risk factors of pigeon paramyxovirus type 1 (PPMV-1) infection in humans are poorly known. We performed virological, pathological and epidemiological analyses of a Dutch case, and compared the results with those of a US case. Both infections occurred in transplant patients under immunosuppressive therapy and caused fatal respiratory failure. Both virus isolates clustered with avian paramyxovirus type 1 (APMV-1) genotype VIb/1, which has pigeons and doves as reservoir. Experimentally inoculated pigeons became infected and transmitted the virus to naïve pigeons. Likely route of transmission to both patients was direct or indirect contact with infected pigeons or doves. Given the large populations of feral pigeons with endemic PPMV-1 infection in cities, increasing urbanisation and a higher proportion of immunocompromised individuals, the risk of severe human PPMV-1 infections may increase. We recommend to test for APMV-1, including PPMV-1, in respiratory disease cases where common respiratory pathogens cannot be identified.
    • Zwangerschap en de ziekte van Chagas.

      Hinfaran AD; Pattipeilohy J; Fanoy E; Kortbeek T; Gool T (2018-04)
    • Zwemmen in de gracht: hoe groot zijn de infectierisico's?

      Joosten R; Kliffen S; Hintaran P; Brandwagt D; Pijnacker R; Lodder W; Siedenburg E; Sonder G; Fanoy E (2019-01)