• Appropriate antibiotic use reduces length of hospital stay.

      van den Bosch, Caroline M A; Hulscher, Marlies E J L; Akkermans, Reinier P; Wille, Jan; Geerlings, Suzanne E; Prins, Jan M (2017)
      To define appropriate antibiotic use in hospitalized adults treated for a bacterial infection, we previously developed and validated a set of six generic quality indicators (QIs) covering all steps in the process of antibiotic use. We assessed the association between appropriate antibiotic use, defined by these QIs, and length of hospital stay (LOS).
    • Distribution of serotypes and patterns of antimicrobial resistance among commensal Streptococcus pneumoniae in nine European countries.

      Yahiaoui, Rachid Y; Bootsma, Hester J; den Heijer, Casper D J; Pluister, Gerlinde N; John Paget, W; Spreeuwenberg, Peter; Trzcinski, Krzysztof; Stobberingh, Ellen E (2018-08-29)
      Streptococcus pneumoniae is a commensal of the human upper respiratory tract and a major cause of morbidity and mortality worldwide. This paper presents the distribution of serotypes and antimicrobial resistance in commensal S. pneumoniae strains cultured from healthy carriers older than four years of age in nine European countries.
    • Necrotising fasciitis as atypical presentation of infection with emerging Neisseria meningitidis serogroup W (MenW) clonal complex 11, the Netherlands, March 2017.

      Russcher, Anne; Fanoy, Ewout; van Olden, Ger D J; Graafland, Antonie D; van der Ende, Arie; Knol, Mirjam J (2017-06-08)
      In March 2017, a patient with necrotising fasciitis caused by Neisseria meningitidis serogroup W (MenW) clonal complex 11 was diagnosed in the Netherlands. Unusual and severe presentations of MenW infections are common in the current European epidemic. In the Netherlands, the incidence of MenW infections increased 10-fold, from an average of 0.03 per 100,000 population in 2002-2014 to 0.29 in 2016. Awareness of atypical presentations enables timely adequate treatment and public health action.
    • Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands.

      Zomer, T P; VAN Duijkeren, E; Wielders, C C H; Veenman, C; Hengeveld, P; VAN DER Hoek, W; DE Greeff, S C; Smit, L A M; Heederik, D J; Yzermans, C J; et al. (2017)
      A cross-sectional study was performed among 2494 adults not living or working on a farm to assess prevalence of Clostridium difficile (CD) colonization and risk factors in a livestock dense area. CD prevalence was 1·2%. Twenty-one persons were colonized with a toxigenic strain and nine with a non-toxigenic strain. CD-positive persons did not live closer to livestock farms than individuals negative for CD. Antibiotic exposure in the preceding 3 months was a risk factor for CD colonization (odds ratio 3·70; 95% confidence interval 1·25-10·95).
    • Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women.

      van Nieuwkoop, Cees; van der Starre, Willize E; Stalenhoef, Janneke E; van Aartrijk, Anna M; van der Reijden, Tanny J K; Vollaard, Albert M; Delfos, Nathalie M; van 't Wout, Jan W; Blom, Jeanet W; Spelt, Ida C; et al. (2017-04-03)
      In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking.