• Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes.

      den Braver, Nicolette R; Rutters, Femke; van der Spek, Andrea L J Kortlever; Ibi, Dorina; Looman, Moniek; Geelen, Anouk; Elders, Petra; van der Heijden, Amber A; Brug, Johannes; Lakerveld, Jeroen; et al. (2019-07-24)
      During a mean follow-up of 6.3 ± 0.7 years, 837 participants developed preT2D and 321 participants developed T2D. The highest adherence to the DHD15-index was significantly associated with lower T2D incidence [model 3, PRT3vsT1: 0.70 (0.53; 0.92), ptrend = 0.01]. The highest adherence to the DHD15-index pointed towards a lower incidence of preT2D [PRT3vsT1: 0.87 (0.74; 1.03), ptrend = 0.11]. Higher adherence to the DHD15-index was not associated with change in fasting plasma glucose levels [β10point: - 0.012 (- 0.034; 0.009)mmol/L].
    • Adherence to the Dutch dietary guidelines and 15-year incidence of heart failure in the EPIC-NL cohort.

      Harbers, Marjolein C; de Kroon, A Marleen; Boer, Jolanda M A; Asselbergs, Folkert W; Geleijnse, Johanna M; Verschuren, W M Monique; van der Schouw, Yvonne T; Sluijs, Ivonne (2020-01-07)
      The average score on the DHD15-index was 71 (SD = 15). During a median follow-up of 15.2 years (IQR 14.1-16.5), 674 HF events occurred. After adjustment for demographic and lifestyle characteristics, higher scores on the DHD15-index were associated with lower risk of HF (HRQ4vsQ1 0.73; 95% CI 0.58-0.93; Ptrend 0.001).
    • Adherence to the WCRF/AICR Dietary Recommendations for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United States: A Meta-Analysis within the CHANCES Project.

      Jankovic, Nicole; Geelen, Anouk; Winkels, Renate M; Mwungura, Blaise; Fedirko, Veronika; Jenab, Mazda; Illner, Anne K; Brenner, Hermann; Ordóñez-Mena, José M; Kiefte de Jong, Jessica C; et al. (2017)
      It is unknown whether dietary recommendations for cancer prevention are applicable to the elderly. We analyzed WCRF/AICR recommendations in cohorts of European and U.S. adults ages 60 years and above.
    • Adhering to a national surgical care bundle reduces the risk of surgical site infections.

      Koek, Mayke B G; Hopmans, Titia E M; Soetens, Loes C; Wille, Jan C; Geerlings, Suzanne E; Vos, Margreet C; van Benthem, Birgit H B; de Greeff, Sabine C (2017)
      In 2008, a bundle of care to prevent Surgical Site Infections (SSIs) was introduced in the Netherlands. The bundle consisted of four elements: antibiotic prophylaxis according to local guidelines, no hair removal, normothermia and 'hygiene discipline' in the operating room (i.e. number of door movements). Dutch hospitals were advised to implement the bundle and to measure the outcome. This study's goal was to assess how effective the bundle was in reducing SSI risk.
    • Adhering to the 2017 Dutch Physical Activity Guidelines: A Trend over Time 2001-2018.

      Duijvestijn, Marjolein; van den Berg, Saskia W; Wendel-Vos, G C Wanda (2020-01-21)
    • Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study.

      Dossus, Laure; Franceschi, Silvia; Biessy, Carine; Navionis, Anne-Sophie; Travis, Ruth C; Weiderpass, Elisabete; Scalbert, Augustin; Romieu, Isabelle; Tjønneland, Anne; Olsen, Anja; et al. (2018-04-01)
      Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49-0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67-2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13-2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80-3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
    • Adipose gene expression response of lean and obese mice to short-term dietary restriction.

      Schothorst, Evert M van; Keijer, Jaap; Pennings, Jeroen L A; Opperhuizen, Antoon; Brom, Charissa E van den; Kohl, Thomas; Franssen-van Hal, Nicole L W; Hoebee, Barbara (2006-06-01)
      Overweight and obesity lead to higher morbidity risks, which are alleviated even by mild weight loss. To gain insight in the molecular effects of weight loss in adipose tissue, we analyzed the effects of short-term dietary restriction (DR) on mice fed a low-fat diet (lean mice) or a high-fat diet (obese mice). Female C57Bl6/J mice on both diets were on DR until an average body weight loss of 20%, which was achieved in 8 to 12 days depending on body weight at the start of DR. Plasma free fatty acids and blood glucose levels decreased significantly on DR. In the (restricted) low-fat diet groups, gene expression analysis using adipose-enriched cDNA microarrays revealed only two transcripts to be significant differentially expressed by DR: up-regulation of malic enzyme (Mod1) and down-regulation of major urinary protein 1 (Mup1). Real-time polymerase chain reaction analysis confirmed these findings and showed, for the high-fat diet groups, an identical expression pattern for Mup1, whereas Mod1 showed an opposed gene expression pattern for the high-fat diet groups. In conclusion, initial weight loss induces transcriptional changes only in a very small number of adipose genes, which also depends on the (restricted) diet used.
    • Adjusting for comorbidity in incidence-based DALY calculations: an individual-based modeling approach.

      McDonald, Scott A; Haagsma, Juanita A; Cassini, Alessandro; Devleesschauwer, Brecht (2020-05-06)
    • ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats

      Dovinová, Ima; Hrabárová, Eva; Jansen, Eugene; Kvandová, Miroslava; Majzúnová, Miroslava; Berenyiová, Andrea; Barančík, Miroslav (2018-10)
    • Adolescent meningococcal serogroup A, W and Y immune responses following immunization with quadrivalent meningococcal A, C, W and Y conjugate vaccine: Optimal age for vaccination.

      van Ravenhorst, Mariëtte B; van der Klis, Fiona R M; van Rooijen, Debbie M; Sanders, Elisabeth A M; Berbers, Guy A M (2017-08-24)
      Recently the incidence of meningococcal serogroup Y (MenY) and in particular serogroup W (MenW) invasive disease has risen in several European countries, including the Netherlands. Adolescents are a target group for primary prevention through vaccination to protect against disease and reduce carriage and induce herd protection in the population. The present study assessed MenA, MenW and MenY antibody levels in adolescents up to one year following primary vaccination with quadrivalent MenACWY-PS conjugated to tetanus toxoid (MenACWY-TT).
    • Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor.

      Barendsen, Rinse W; Dijkstra, Inge M E; Visser, Wouter F; Alders, Mariëlle; Bliek, Jet; Boelen, Anita; Bouva, Marelle J; van der Crabben, Saskia N; Elsinghorst, Ellen; van Gorp, Ankie G M; et al. (2020-01-01)
    • Advance system testing: Vaccine benefit studies using multi-country electronic health data - The example of pertussis vaccination.

      Tin Tin Htar, Myint; de Ridder, Maria; Braeye, Toon; Correa, Ana; McGee, Chris; de Lusignan, Simon; Duarte-Salles, Talita; Huerta, Consuelo; Martín-Merino, Elisa; Tramontan, Lara; et al. (2019-10-31)
    • Advanced Toxicological Risk Assessment by Implementation of Ontologies Operationalized in Computational Models

      Staal, Yvonne C.M.; Pennings, Jeroen L.A.; Hessel, Ellen V.S.; Piersma, Aldert H.; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. (2017-12)
    • Advancing food, nutrition, and health research in Europe by connecting and building research infrastructures in a DISH-RI: Results of the EuroDISH project

      Snoek, Harriëtte M.; Eijssen, Lars M.T.; Geurts, Marjolein; Vors, Cecile; Brown, Kerry A.; Bogaardt, Marc-Jeroen; Dhonukshe-Rutten, Rosalie A.M.; Evelo, Chris T.; Fezeu, Leopold K.; Finglas, Paul M.; et al. (2018-03)
    • Advancing Global Health through Environmental and Public Health Tracking.

      Lauriola, Paolo; Crabbe, Helen; Behbod, Behrooz; Yip, Fuyuen; Medina, Sylvia; Semenza, Jan C; Vardoulakis, Sotiris; Kass, Dan; Zeka, Ariana; Khonelidze, Irma; et al. (2020-03-17)
    • Adverse effects of levamisole in cocaine users: a review and risk assessment.

      Brunt, Tibor Markus; van den Berg, Jorrit; Pennings, Ed; Venhuis, Bastiaan (2017-06)
      The immunomodulatory adjuvant and antihelminth levamisole is increasingly used as an adulterant in cocaine worldwide. An accumulating body of clinical and toxicological literature has appeared since 2010 describing neutropenia, agranulocytosis, leukoencephalopathy and vasculitis in cases associated with levamisole-adulterated cocaine. Mostly, neutropenia and agranulocytosis were reported, characterized by a decimation of neutrophils. A large proportion of cases also involved vasculopathy, characterized by pronounced black and purple skin purpura with cutaneous necrosis. Females are more susceptible for both agranulocytosis and vasculitis. Another complication reported with levamisole-adulterated cocaine is leukoencephalopathy, a disabling and potentially fatal neurological disorder caused by cerebral demyelination. In this review, all adverse effects associated with therapeutic levamisole and levamisole-adulterated cocaine are described. In addition, this review provides an update of the pharmacology of levamisole, its metabolism, including toxic metabolites and metabolites that are relevant for levamisole's addition to cocaine. Special emphasis is put on the immunopathology and the dose-effect relationship of chronic levamisole exposure. Finally, a risk assessment is provided based on the current level of levamisole adulteration in street cocaine, the dose range calculated per gram and the pattern of chronic exposure in heavy or dependent users.
    • An Adverse Outcome Pathway Analysis Employing DNA Methylation Effects in Arsenic-Exposed Zebrafish Embryos Supports a Role of Epigenetic Events in Arsenic-Induced Chronic Disease

      van der Ven, Leo T.M.; Jelinek, Jaroslav; Hodemaekers, Hennie M.; Zwart, Edwin P.; Ruiter, Sander; van den Brandhof, Evert-Jan; Issa, Jean-Pierre J.; Pennings, Jeroen L.A.; Luijten, Mirjam; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; et al. (2017-12)
    • An Adverse Outcome Pathway for Sensitization of the Respiratory Tract by Low-Molecular-Weight Chemicals: Building Evidence to Support the Utility of In Vitro and In Silico Methods in a Regulatory Context

      Sullivan, Kristie M.; Enoch, Steven J.; Ezendam, Janine; Sewald, Katherina; Roggen, Erwin L.; Cochrane, Stella; Physicians Committee for Responsible Medicine, Washington, District of Columbia.; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, England.; National Institute for Public Health and the Environment (RIVM), Centre for Health Protection, Bilthoven, The Netherlands.; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; et al. (2017-09-07)
    • Advice to the European Commission as Regards Type and Criteria for Comprehensive Studies to Be Requested From Manufacturers: The Opinion of the Scientific Committee on Health, Environmental, and Emerging Risks (SCHEER).

      Talhout, Reinskje; Duarte-Davidson, Raquel; Hoet, Peter; Nair, Urmila; Rydzynski, Konrad; Vermeire, Theo; Zacharov, Sergej; Testai, Emanuela (2020-04-21)
    • Afname van foetale en neonatale sterfte in Nederland. Vergelijking met andere EURO-PEROSTAT-Landen in 2004, 2010 en 2015

      Broeders, Lisa; Achterberg, Peter W; Waelput, Adja J M; Ravelli, Anita C J; Kwee, Anneke; Groenendaal, Floris; Offerhaus, Pien; van der Velden, Koos; Rosman, Ageeth N; Nijhuis, Jan G (2019-07-23)