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    Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex.

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    Authors
    Huard, Richard C
    Fabre, Michel
    Haas, Petra de
    Lazzarini, Luiz Claudio Oliveira
    Soolingen, Dick van
    Cousins, Debby
    Ho, John L
    Type
    Article
    Language
    en
    
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    Title
    Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex.
    Publiekssamenvatting
    In a previous report, we described a PCR protocol for the differentiation of the various species of the Mycobacterium tuberculosis complex (MTC) on the basis of genomic deletions (R. C. Huard, L. C. de Oliveira Lazzarini, W. R. Butler, D. van Soolingen, and J. L. Ho, J. Clin. Microbiol. 41:1637-1650, 2003). That report also provided a broad cross-comparison of several previously identified, phylogenetically relevant, long-sequence and single-nucleotide polymorphisms (LSPs and SNPs, respectively). In the present companion report, we expand upon the previous work (i) by continuing the evaluation of known MTC phylogenetic markers in a larger collection of tubercle bacilli (n = 125), (ii) by evaluating additional recently reported MTC species-specific and interspecific polymorphisms, and (iii) by describing the identification and distribution of a number of novel LSPs and SNPs. Notably, new genomic deletions were found in various Mycobacterium tuberculosis strains, new species-specific SNPs were identified for "Mycobacterium canettii," Mycobacterium microti, and Mycobacterium pinnipedii, and, for the first time, intraspecific single-nucleotide DNA differences were discovered for the dassie bacillus, the oryx bacillus, and the two Mycobacterium africanum subtype I variants. Surprisingly, coincident polymorphisms linked one M. africanum subtype I genotype with the dassie bacillus and M. microti with M. pinnipedii, thereby suggesting closer evolutionary ties within each pair of species than had been previously thought. Overall, the presented data add to the genetic definitions of several MTC organisms as well as fine-tune current models for the evolutionary history of the MTC.
    DOI
    10.1128/JB.01783-05
    PMID
    16740934
    URI
    http://hdl.handle.net/10029/4909
    ae974a485f413a2113503eed53cd6c53
    10.1128/JB.01783-05
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