Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Barlow, SRenwick, A G
Kleiner, J
Bridges, J W
Busk, L
Dybing, Erik
Edler, L
Eisenbrand, G
Fink-Gremmels, J
Knaap, A G A C
Kroes, R
Liem, D
Müller, D J G
Page, S
Rolland, V
Schlatter, J
Tritscher, A
Tueting, W
Würtzen, G
Type
ArticleLanguage
en
Metadata
Show full item recordTitle
Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe.Publiekssamenvatting
The European Food Safety Authority (EFSA) and the World Health Organization (WHO), with the support of the International Life Sciences Institute, European Branch (ILSI Europe), organized an international conference on 16-18 November 2005 to discuss how regulatory and advisory bodies evaluate the potential risks of the presence in food of substances that are both genotoxic and carcinogenic. The objectives of the conference were to discuss the possible approaches for risk assessment of such substances, how the approaches may be interpreted and whether they meet the needs of risk managers. ALARA (as low as reasonably achievable) provides advice based solely on hazard identification and does not take into account either potency or human exposure. The use of quantitative low-dose extrapolation of dose-response data from an animal bioassay raises numerous scientific uncertainties related to the selection of mathematical models and extrapolation down to levels of human exposure. There was consensus that the margin of exposure (MOE) was the preferred approach because it is based on the available animal dose-response data, without extrapolation, and on human exposures. The MOE can be used for prioritisation of risk management actions but the conference recognised that it is difficult to interpret it in terms of health risk.PMID
16891049ae974a485f413a2113503eed53cd6c53
10.1016/j.fct.2006.06.020
Scopus Count
Collections
Related articles
- Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic.
- Authors: Benford D, Bolger PM, Carthew P, Coulet M, DiNovi M, Leblanc JC, Renwick AG, Setzer W, Schlatter J, Smith B, Slob W, Williams G, Wildemann T
- Issue date: 2010 Jan
- Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal.
- Authors: O'Brien J, Renwick AG, Constable A, Dybing E, Müller DJ, Schlatter J, Slob W, Tueting W, van Benthem J, Williams GM, Wolfreys A
- Issue date: 2006 Oct
- The influence of thresholds on the risk assessment of carcinogens in food.
- Authors: Pratt I, Barlow S, Kleiner J, Larsen JC
- Issue date: 2009 Aug
- Towards a harmonized approach for risk assessment of genotoxic carcinogens in the European Union.
- Authors: Crebelli R
- Issue date: 2006
- Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
- Authors: Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M
- Issue date: 2017 Jun