Show simple item record

dc.contributor.authorGrundmann, Hajo
dc.contributor.authorAires-de-Sousa, Marta
dc.contributor.authorBoyce, John
dc.contributor.authorTiemersma, Edine
dc.date.accessioned2006-10-24T11:59:06Z
dc.date.available2006-10-24T11:59:06Z
dc.date.issued2006-09-02
dc.identifier.citationLancet 2006, 368(9538):874-85en
dc.identifier.issn1474-547X
dc.identifier.pmid16950365
dc.identifier.doi10.1016/S0140-6736(06)68853-3
dc.identifier.urihttp://hdl.handle.net/10029/5555
dc.description.abstractStaphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25-30% of healthy people. Dependent on its intrinsic virulence or the ability of the host to contain its opportunistic behaviour, S aureus can cause a range of diseases in man. The bacterium readily acquires resistance against all classes of antibiotics by one of two distinct mechanisms: mutation of an existing bacterial gene or horizontal transfer of a resistance gene from another bacterium. Several mobile genetic elements carrying exogenous antibiotic resistance genes might mediate resistance acquisition. Of all the resistance traits S aureus has acquired since the introduction of antimicrobial chemotherapy in the 1930s, meticillin resistance is clinically the most important, since a single genetic element confers resistance to the most commonly prescribed class of antimicrobials--the beta-lactam antibiotics, which include penicillins, cephalosporins, and carbapenems.
dc.format.extent491367 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleEmergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T13:42:02Z
html.description.abstractStaphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25-30% of healthy people. Dependent on its intrinsic virulence or the ability of the host to contain its opportunistic behaviour, S aureus can cause a range of diseases in man. The bacterium readily acquires resistance against all classes of antibiotics by one of two distinct mechanisms: mutation of an existing bacterial gene or horizontal transfer of a resistance gene from another bacterium. Several mobile genetic elements carrying exogenous antibiotic resistance genes might mediate resistance acquisition. Of all the resistance traits S aureus has acquired since the introduction of antimicrobial chemotherapy in the 1930s, meticillin resistance is clinically the most important, since a single genetic element confers resistance to the most commonly prescribed class of antimicrobials--the beta-lactam antibiotics, which include penicillins, cephalosporins, and carbapenems.


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
grundmann.pdf
Size:
479.8Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record