Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat.
dc.contributor.author | Grundmann, Hajo | |
dc.contributor.author | Aires-de-Sousa, Marta | |
dc.contributor.author | Boyce, John | |
dc.contributor.author | Tiemersma, Edine | |
dc.date.accessioned | 2006-10-24T11:59:06Z | |
dc.date.available | 2006-10-24T11:59:06Z | |
dc.date.issued | 2006-09-02 | |
dc.identifier.citation | Lancet 2006, 368(9538):874-85 | en |
dc.identifier.issn | 1474-547X | |
dc.identifier.pmid | 16950365 | |
dc.identifier.doi | 10.1016/S0140-6736(06)68853-3 | |
dc.identifier.uri | http://hdl.handle.net/10029/5555 | |
dc.description.abstract | Staphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25-30% of healthy people. Dependent on its intrinsic virulence or the ability of the host to contain its opportunistic behaviour, S aureus can cause a range of diseases in man. The bacterium readily acquires resistance against all classes of antibiotics by one of two distinct mechanisms: mutation of an existing bacterial gene or horizontal transfer of a resistance gene from another bacterium. Several mobile genetic elements carrying exogenous antibiotic resistance genes might mediate resistance acquisition. Of all the resistance traits S aureus has acquired since the introduction of antimicrobial chemotherapy in the 1930s, meticillin resistance is clinically the most important, since a single genetic element confers resistance to the most commonly prescribed class of antimicrobials--the beta-lactam antibiotics, which include penicillins, cephalosporins, and carbapenems. | |
dc.format.extent | 491367 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.title | Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. | en |
dc.type | Article | en |
dc.format.dig | YES | |
refterms.dateFOA | 2018-12-18T13:42:02Z | |
html.description.abstract | Staphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25-30% of healthy people. Dependent on its intrinsic virulence or the ability of the host to contain its opportunistic behaviour, S aureus can cause a range of diseases in man. The bacterium readily acquires resistance against all classes of antibiotics by one of two distinct mechanisms: mutation of an existing bacterial gene or horizontal transfer of a resistance gene from another bacterium. Several mobile genetic elements carrying exogenous antibiotic resistance genes might mediate resistance acquisition. Of all the resistance traits S aureus has acquired since the introduction of antimicrobial chemotherapy in the 1930s, meticillin resistance is clinically the most important, since a single genetic element confers resistance to the most commonly prescribed class of antimicrobials--the beta-lactam antibiotics, which include penicillins, cephalosporins, and carbapenems. |