Show simple item record

dc.contributor.authorSchielen, P C J I
dc.contributor.authorLeeuwen-Spruijt, M van
dc.contributor.authorBelmouden, I
dc.contributor.authorElvers, L H
dc.contributor.authorJonker, M
dc.contributor.authorLoeber, J G
dc.date.accessioned2006-10-24T12:46:22Z
dc.date.available2006-10-24T12:46:22Z
dc.date.issued2006-08-01
dc.identifier.citationPrenat. Diagn. 2006, 26(8):711-8en
dc.identifier.issn0197-3851
dc.identifier.pmid16752435
dc.identifier.doi10.1002/pd.1486
dc.identifier.urihttp://hdl.handle.net/10029/5557
dc.description.abstractOBJECTIVES: This is the first report on the results of a first-trimester combined-test screening programme in the Netherlands in a multi-centre routine clinical setting. METHODS: Between July 2002 and May 2004, blood samples were taken from subjects in 44 centres in the Netherlands and sent to our laboratory to assay for maternal serum concentrations of fbeta-hCG and PAPP-A. Fetal nuchal translucency (NT) was measured in the participating centres at a gestational age (GA) of 10-14 weeks. Results of those pregnancies for which a combined biochemical and NT risk was calculated were included in the epidemiological analysis of this study. RESULTS: A total of 4033 singleton pregnancies were included in the analysis. The median maternal age of the analysed group was 36.5 years. The distribution of GA was biphasic, with median GA of 10.3 and 12.1 weeks, respectively. The detection rate using the combined ultrasound and serum screening at a cut-off level of 1 in 250 was 71% (15/21), with a screen-positive rate of 4.7%. CONCLUSION: The results of this study show that the first-trimester combined test is suitable as a prenatal screening test in a multi-centre routine clinical setting in the Netherlands. Strict performance evaluation should identify weaknesses in the organisation that impair the performance of the test. Here, the performance of NT was especially identified as a candidate for improvement.
dc.format.extent262903 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleMulti-centre first-trimester screening for Down syndrome in the Netherlands in routine clinical practice.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T13:42:13Z
html.description.abstractOBJECTIVES: This is the first report on the results of a first-trimester combined-test screening programme in the Netherlands in a multi-centre routine clinical setting. METHODS: Between July 2002 and May 2004, blood samples were taken from subjects in 44 centres in the Netherlands and sent to our laboratory to assay for maternal serum concentrations of fbeta-hCG and PAPP-A. Fetal nuchal translucency (NT) was measured in the participating centres at a gestational age (GA) of 10-14 weeks. Results of those pregnancies for which a combined biochemical and NT risk was calculated were included in the epidemiological analysis of this study. RESULTS: A total of 4033 singleton pregnancies were included in the analysis. The median maternal age of the analysed group was 36.5 years. The distribution of GA was biphasic, with median GA of 10.3 and 12.1 weeks, respectively. The detection rate using the combined ultrasound and serum screening at a cut-off level of 1 in 250 was 71% (15/21), with a screen-positive rate of 4.7%. CONCLUSION: The results of this study show that the first-trimester combined test is suitable as a prenatal screening test in a multi-centre routine clinical setting in the Netherlands. Strict performance evaluation should identify weaknesses in the organisation that impair the performance of the test. Here, the performance of NT was especially identified as a candidate for improvement.


Files in this item

Thumbnail
Name:
schielen.pdf
Size:
256.7Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record