Molecular epidemiology of Neisseria gonorrhoeae in Amsterdam, The Netherlands, shows distinct heterosexual and homosexual networks.
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Dukers, Nicole H T M
Bij, Akke K van der
Fennema, Johan S A
Coutinho, Roel A
Bruisten, Sylvia M
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TitleMolecular epidemiology of Neisseria gonorrhoeae in Amsterdam, The Netherlands, shows distinct heterosexual and homosexual networks.
PubliekssamenvattingMolecular typing, added to epidemiological data, can better identify transmission patterns of gonorrhea in Western countries, where the incidence has recently been rising. From September 2002 to September 2003, patients with a laboratory-confirmed diagnosis of gonorrhea at the Clinic for Sexually Transmitted Infections in Amsterdam, The Netherlands, were subjected to a questionnaire pertaining to sexual risk behavior and sexual partners in the 6 months prior to the diagnosis. The Neisseria gonorrhoeae isolates were all genotyped using PCR-restriction fragment length polymorphism of the porin and opacity genes. All patients with a completed questionnaire and genotyped isolates were included in the study. We obtained 885 N. gonorrhoeae isolates from 696 patients that revealed 88 clusters and 46 unique genotypes. Patients infected at multiple anatomical sites with one or more strains and patients infected several times during the study period were shown to pursue high-risk sexual behavior and were considered core groups. There were 11 clusters of > or =20 patients; in seven clusters, 81% to 100% of patients were men who have sex with men (MSM), three clusters contained 87 to 100% heterosexual men and women, and one cluster was formed by equal proportions of MSM and heterosexual male and female patients. However, the various clusters differed in characteristics such as types of coinfections, numbers of sexual partners, Internet use to seek sexual partners, and locations of sexual encounters. Molecular epidemiology of gonococcal isolates in Amsterdam revealed core groups and clusters of MSM and heterosexual patients that probably indicate distinct transmission networks.
- Distinct Neisseria gonorrhoeae transmission networks among men who have sex with men in Amsterdam, The Netherlands.
- Authors: Heymans R, A Matser A, Bruisten SM, Heijman T, Geskus RB, Speksnijder AG, Davidovich U, de Vries HJ, Coutinho RA, Schim van der Loeff MF
- Issue date: 2012 Aug 15
- Comparison of Neisseria gonorrhoeae multiantigen sequence typing and porB sequence analysis for identification of clusters of N. gonorrhoeae isolates.
- Authors: Liao M, Helgeson S, Gu WM, Yang Y, Jolly AM, Dillon JA
- Issue date: 2009 Feb
- Multiple-locus variable-number tandem repeat analysis of Neisseria gonorrhoeae.
- Authors: Heymans R, Schouls LM, van der Heide HG, van der Loeff MF, Bruisten SM
- Issue date: 2011 Jan
- Amplified fragment length polymorphism fingerprinting for identification of a core group of Neisseria gonorrhoeae transmitters in the population attending a clinic for treatment of sexually transmitted diseases in Amsterdam, The Netherlands.
- Authors: Spaargaren J, Stoof J, Fennema H, Coutinho R, Savelkoul P
- Issue date: 2001 Jun
- Phenotypic and genotypic characterization of Neisseria gonorrhoeae in parts of Italy: detection of a multiresistant cluster circulating in a heterosexual network.
- Authors: Starnino S, Suligoi B, Regine V, Bilek N, Stefanelli P, Neisseria gonorrhoeae Italian Study Group., Dal Conte I, Flanchino B, Delmonte S, Robbiano F, D'Antuono A, Mirone E, Matteelli A, De Francesco MA, Cusini M, Scioccati L, Di Carlo A, Prignano G, Salfa MC
- Issue date: 2008 Oct