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    Short- and long-term variations of norovirus concentrations in the Meuse river during a 2-year study period.

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    Authors
    Westrell, Therese
    Teunis, Peter F M
    Berg, Harold H J L van den
    Lodder, Willemijn J
    Ketelaars, Henk
    Stenström, Thor Axel
    Roda Husman, Ana Maria de
    Type
    Article
    Language
    en
    
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    Title
    Short- and long-term variations of norovirus concentrations in the Meuse river during a 2-year study period.
    Publiekssamenvatting
    Faecally impacted surface waters used for drinking water production may encompass risk for norovirus infections. To be able to assess a possible health risk, noroviruses should be quantified and fluctuations identified. In 2001, norovirus concentrations in the river Meuse displayed a seasonal distribution with high peaks during wintertime as determined by RT-PCR on serially diluted RNA. An intensified day-by-day sampling scheme in the winter of 2002/2003 revealed that the winter peak consisted of several peaks of varying duration and magnitude, possibly due to contamination events in the catchment. The highest estimated concentration was 1700 PCR-detectable units per litre (95% CI 250-8000), which if coinciding with failing treatment could lead to significant numbers in drinking water. Adaptive dynamic filtering was shown to adequately predict subsequent sample concentrations. If valid, such analyses could prove to be useful as early warning systems in risk management of water sources.
    DOI
    10.1016/j.watres.2006.05.019
    PMID
    16839583
    URI
    http://hdl.handle.net/10029/5570
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.watres.2006.05.019
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