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    Assessing the introduction of universal varicella vaccination in the Netherlands.

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    Authors
    Boot, Hein J
    Melker, Hester E de
    Stolk, Elly A
    Wit, G Ardine de
    Kimman, Tjeerd G
    Type
    Article
    Language
    en
    
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    Title
    Assessing the introduction of universal varicella vaccination in the Netherlands.
    Publiekssamenvatting
    Although varicella is seen as a benign disease in the Netherlands, about 40,000 visits to a general practitioner (GP) are made, over 200 hospital admission occur, and 2.3 persons die on average each year. Most of this burden of disease can be prevented by universal varicella childhood vaccination. Ten years after the introduction of the single-shot, single-component varicella childhood vaccination in the USA, a major reduction in hospitalization, mortality, and burden of disease has been reported. Using our recently vaccine evaluation model for the introduction of a new vaccine in our national immunization program, we have analyzed the feasibility of universal varicella vaccination by replacing the measles-mumps-rubella (MMR) vaccine with a measles-mumps-rubella-varicella (MMRV) vaccine. After structuring and reviewing the available data, two major points of uncertainty remain: (1) the influence of universal childhood vaccination on the incidence of zoster later in life; (2) the cost-effectiveness ratio for the Dutch situation. Despite these uncertainties it is clear that universal childhood vaccination will prevent most of the varicella related GP-visits, hospitalizations, and deaths.
    DOI
    10.1016/j.vaccine.2006.05.071
    PMID
    16790302
    URI
    http://hdl.handle.net/10029/5600
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2006.05.071
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